Recent Advances in Antimicrobial Peptides to Improve Fish Health

Priyam, Manisha; Bhat, Rayees Ahmad; Kumar, Neeraj

doi:10.1007/978-981-16-5195-3_8

Cited by 1 publication

(2 citation statements)

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“…The interaction of some piscidin peptides with membranes can also have immunomodulatory effects, including the activation of immune cells and the regulation of cytokine and chemokine production [111,112]. This makes piscidins attractive candidates for the development of novel antimicrobial and immunomodulatory therapeutics [20]. Specifically, piscidins have been shown to stimulate the proliferation and activation of T cells, including both CD4+ and CD8+ T cells.…”

Section: Functionmentioning

confidence: 99%

“…Similarly, mucus extracts from the skin of several fish species, including rainbow trout, have been identified as having antimicrobial peptides against selected bacteria [18]. Host defense peptides have been found to have close genetic, structural, and functional relatives in non-fish species thanks to advances in genome sequencing research [19,20]. Recent research has shown that the peptide piscidin is synthesized in the epithelia of the gills, skin, stomach, and gut of a variety of Teleost species.…”

Section: Introductionmentioning

confidence: 99%

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Teleost Piscidins—In Silico Perspective of Natural Peptide Antibiotics from Marine Sources

et al. 2023

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Fish, like all other animals, are exposed to constant contact with microbes, both on their skin and on the surfaces of their respiratory and digestive systems. Fish have a system of non-specific immune responses that provides them with initial protection against infection and allows them to survive under normal conditions despite the presence of these potential invaders. However, fish are less protected against invading diseases than other marine vertebrates because their epidermal surface, composed primarily of living cells, lacks the keratinized skin that serves as an efficient natural barrier in other marine vertebrates. Antimicrobial peptides (AMPs) are one type of innate immune protection present in all life forms. AMPs have been shown to have a broader range of biological effects than conventional antibiotics, including antibacterial, antiviral, antiprotozoal, and antifungal effects. Although other AMPs, such as defensins and hepcidins, are found in all vertebrates and are relatively well conserved, piscidins are found exclusively in Teleost fish and are not found in any other animal. Therefore, there is less information on the expression and bioactivity of piscidins than on other AMPs. Piscidins are highly effective against Gram-positive and Gram-negative bacteria that cause disease in fish and humans and have the potential to be used as pharmacological anti-infectives in biomedicine and aquaculture. To better understand the potential benefits and limitations of using these peptides as therapeutic agents, we are conducting a comprehensive study of the Teleost piscidins included in the “reviewed” category of the UniProt database using bioinformatics tools. They all have amphipathic alpha-helical structures. The amphipathic architecture of piscidin peptides and positively charged residues influence their antibacterial activity. These alpha-helices are intriguing antimicrobial drugs due to their stability in high-salt and metal environments. New treatments for multidrug-resistant bacteria, cancer, and inflammation may be inspired by piscidin peptides.

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Section: Functionmentioning

confidence: 99%