Recent advances in antiviral activities and potential mechanisms of sulfated polysaccharides

Lu, Wenjing; Yang, Zhen; Chen, Juan; Wang, Di; Zhang, Yu

doi:10.1016/j.carbpol.2021.118526

Cited by 74 publications

(40 citation statements)

References 74 publications

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“… CS esterification modification scheme: ( A ) Synthesis route of sulfated chitosan. Adapted with permission from [ 66 ], Copyright © 2021 Elsevier. ( B ) synthesis route of phosphorylated chitosan.…”

Section: Chemical Modification Technology For Chitosanmentioning

confidence: 99%

Progress in Research of Chitosan Chemical Modification Technologies and Their Applications

Chen

Jiang

et al. 2022

Marine Drugs

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Chitosan, which is derived from chitin, is the only known natural alkaline cationic polymer. Chitosan is a biological material that can significantly improve the living standard of the country. It has excellent properties such as good biodegradability, biocompatibility, and cell affinity, and has excellent biological activities such as antibacterial, antioxidant, and hemostasis. In recent years, the demand has increased significantly in many fields and has huge application potential. Due to the poor water solubility of chitosan, its wide application is limited. However, chemical modification of the chitosan matrix structure can improve its solubility and biological activity, thereby expanding its application range. The review covers the period from 1996 to 2022 and was elaborated by searching Google Scholar, PubMed, Elsevier, ACS publications, MDPI, Web of Science, Springer, and other databases. The various chemical modification methods of chitosan and its main activities and application research progress were reviewed. In general, the modification of chitosan and the application of its derivatives have had great progress, such as various reactions, optimization of conditions, new synthetic routes, and synthesis of various novel multifunctional chitosan derivatives. The chemical properties of modified chitosan are usually better than those of unmodified chitosan, so chitosan derivatives have been widely used and have more promising prospects. This paper aims to explore the latest progress in chitosan chemical modification technologies and analyze the application of chitosan and its derivatives in various fields, including pharmaceuticals and textiles, thus providing a basis for further development and utilization of chitosan.

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Section: Chemical Modification Technology For Chitosanmentioning

confidence: 99%

Progress in Research of Chitosan Chemical Modification Technologies and Their Applications

Chen

Jiang

et al. 2022

Marine Drugs

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“…In addition, seaweed polysaccharides can inhibit viral transcription and replication through direct interference with viral replication enzymes or inhibition on other intracellular targets [ 140 ]. Marine polysaccharides, especially sulfated polysaccharides from marine algae, appear to block viral infection by inhibition of one or more of these stages, with the specific mechanisms dependent on the structure of the individual polysaccharide [ 140 , 141 , 142 , 143 , 144 ].…”

Section: Conclusion and Future Outlooksmentioning

confidence: 99%

Advances in Research on Antiviral Activities of Sulfated Polysaccharides from Seaweeds

Wei

Wang

et al. 2022

Pharmaceuticals

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In recent years, various viral diseases have suddenly erupted, resulting in widespread infection and death. A variety of biological activities from marine natural products have gradually attracted the attention of people. Seaweeds have a wide range of sources, huge output, and high economic benefits. This is very promising in the pharmaceutical industry. In particular, sulfated polysaccharides derived from seaweeds, considered a potential source of bioactive compounds for drug development, have shown antiviral activity against a broad spectrum of viruses, mainly including common DNA viruses and RNA viruses. In addition, sulfated polysaccharides can also improve the body’s immunity. This review focuses on recent advances in antiviral research on the sulfated polysaccharides from seaweeds, including carrageenan, galactan, fucoidan, alginate, ulvan, p-KG03, naviculan, and calcium spirulan. We hope that this review will provide new ideas for the development of COVID-19 therapeutics and vaccines.

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“…The flexibility of sugar chains has been reported as one of the main features of polysaccharide solutions' confirmation, together with morphological characteristics and polysaccharide conformation. The presence of sulfates on a polysaccharide chain also improves the solubility and antioxidant activity by forming a more outstretched conformation than non-sulfated polysaccharides [97][98][99]. Findings related to the influenza A virus were derived from the further assessment regarding fucoidan isolated from Kjellmaniella crassifolia, with exceptional results from other studies.…”

Section: Fucoidanmentioning

confidence: 99%

Antiviral Activities of Algal-Based Sulfated Polysaccharides

Panggabean

Adiguna

Rahmawati³

et al. 2022

Molecules

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An antiviral agent is urgently needed based on the high probability of the emergence and re-emergence of future viral disease, highlighted by the recent global COVID-19 pandemic. The emergence may be seen in the discovery of the Alpha, Beta, Gamma, Delta, and recently discovered Omicron variants of SARS-CoV-2. The need for strategies besides testing and isolation, social distancing, and vaccine development is clear. One of the strategies includes searching for an antiviral agent that provides effective results without toxicity, which is well-presented by significant results for carrageenan nasal spray in providing efficacy against human coronavirus-infected patients. As the primary producer of sulfated polysaccharides, marine plants, including macro- and microalgae, offer versatility in culture, production, and post-isolation development in obtaining the needed antiviral agent. Therefore, this review will describe an attempt to highlight the search for practical and safe antiviral agents from algal-based sulfated polysaccharides and to unveil their features for future development.

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Recent advances in antiviral activities and potential mechanisms of sulfated polysaccharides

Cited by 74 publications

References 74 publications

Progress in Research of Chitosan Chemical Modification Technologies and Their Applications

Progress in Research of Chitosan Chemical Modification Technologies and Their Applications

Advances in Research on Antiviral Activities of Sulfated Polysaccharides from Seaweeds

Antiviral Activities of Algal-Based Sulfated Polysaccharides

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