Recent advances in application of cyclodextrin-based chiral materials for enantioseparation

Qiu, Huiyun; Zhu, Beibei; Zhu, Junchao; Chen, Songlin; Ma, Chenlei; Xiang, Haiping; Tong, Shengqiang

doi:10.1016/j.trac.2024.117708

TrAC Trends in Analytical Chemistry

2024

DOI: 10.1016/j.trac.2024.117708

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Recent advances in application of cyclodextrin-based chiral materials for enantioseparation

Huiyun Qiu,

Beibei Zhu,

Junchao Zhu

et al.

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Cited by 3 publications

References 192 publications

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Sustainable solutions for direct TLC enantioseparation with in‐home thought‐out, prepared/modified chiral stationary phases

Bhushan

2024

Biomedical Chromatography

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TLC is used globally, yet less attention has been paid to TLC (in enantioseparation) despite its advantages. The present paper describes/reviews successfully practiced direct approaches of ‘chiral additive in achiral stationary phase’ (as an application of in‐home thought out, prepared, tested, and modified chiral stationary phase), ‘pre‐mixing of chiral reagent with the enantiomeric mixture’ (an approach using both achiral phases during chromatographic separation) and ‘chiral additive in mobile phase’, and chiral ligand exchange for enantioseparation of DL‐amino acids, their derivatives, and some active pharmaceutical ingredients. It provided efficient enantioseparation, quantitative determination, and isolation of native forms via in‐situ formation of non‐covalent diastereomeric pair. The mechanism of enantioseparation in these approaches has been discussed along with the isolation and establishment of the structure of diastereomers. This may help chemists gain useful insights into fields outside their specialization and the experts get brief accounts of recent key developments, providing solutions for sustainable development of less expensive methods for control of enantiomeric purity and isolation of native enantiomers.

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Sustainable solutions for direct TLC enantioseparation with in‐home thought‐out, prepared/modified chiral stationary phases

Bhushan

2024

Biomedical Chromatography

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Colorimetric enantioselective detection of D-alanine using chiral β-cyclodextrin-modified Au nanoparticles and their multicolor Tyndall effect

Huang,

Jiang,

et al. 2025

Sensors and Actuators B: Chemical

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Review of Applications of β-Cyclodextrin as a Chiral Selector for Effective Enantioseparation

Napiórkowska,

Szeleszczuk

2024

IJMS

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The significance and necessity of separating enantiomers in food, pharmaceuticals, pesticides, and other samples remains constant and unrelenting. The successful chiral separation usually includes the application of a chiral auxiliary compound, known also as a chiral selector (CS), that forms complexes with enantiomers of different physicochemical properties, enabling efficient separation. While both native and substituted cyclodextrins (CDs) are commonly used as CSs, β-CD is undoubtedly the most popular one among them. This review includes recent advancements in the application of β-CD as a CS. While the theoretical background behind the enantioseparation is also part of this work, the main emphasis is put on the factors that affect the efficacy of this process such as temperature, pH, solvent, and the choice of other additives. Also, the different analytical methods: Nuclear Magnetic Resonance (NMR) spectroscopy, Capillary Electrophoresis (CE), fluorescence spectroscopy (FS), High-Performance Liquid Chromatography (HPLC), Isothermal Titration Calorimetry (ITC), and UV–vis spectroscopy, used for enantioseparation with the aid of β-CD as CS, are thoroughly compared. Also, since some of the chiral compounds have been studied in the context of their enantioseparation more than once, those works are compared and critically analyzed. In conclusion, while β-CD can be in most cases used as CS, the choice of the experimental conditions and method of analysis is crucial to achieve the success.

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Recent advances in application of cyclodextrin-based chiral materials for enantioseparation

Cited by 3 publications

References 192 publications

Sustainable solutions for direct TLC enantioseparation with in‐home thought‐out, prepared/modified chiral stationary phases

Sustainable solutions for direct TLC enantioseparation with in‐home thought‐out, prepared/modified chiral stationary phases

Colorimetric enantioselective detection of D-alanine using chiral β-cyclodextrin-modified Au nanoparticles and their multicolor Tyndall effect

Review of Applications of β-Cyclodextrin as a Chiral Selector for Effective Enantioseparation

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