Recent advances in applications of nanoparticles in <scp>SERS</scp> in vivo imaging

Du, Zhen; Qi, Yuchen; He, Jian; Zhong, Danni; Zhou, Min

doi:10.1002/wnan.1672

Cited by 59 publications

(48 citation statements)

References 105 publications

(109 reference statements)

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“…Owing to their high uptake by tumors and high signal specificity, SE(R)RS nanostars offer tremendous opportunities for cancer diagnostics and imaging [191,192]. However, like any other optical imaging technology, tissue depth penetration is limited and therefore deep tissue-or whole-body imaging is not supported by conventional Raman imaging.…”

Section: Multimodal Imaging and Theranostic Applicationsmentioning

confidence: 99%

Design and synthesis of gold nanostars-based SERS nanotags for bioimaging applications

Andreiuk¹,

Nicolson²,

Clark³

et al. 2022

Nanotheranostics

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Surface-enhanced Raman spectroscopy (SERS) nanotags hold a unique place among bioimaging contrast agents due to their fingerprint-like spectra, which provide one of the highest degrees of detection specificity. However, in order to achieve a sufficiently high signal intensity, targeting capabilities, and biocompatibility, all components of nanotags must be rationally designed and tailored to a specific application. Design parameters include fine-tuning the properties of the plasmonic core as well as optimizing the choice of Raman reporter molecule, surface coating, and targeting moieties for the intended application. This review introduces readers to the principles of SERS nanotag design and discusses both established and emerging protocols of their synthesis, with a specific focus on the construction of SERS nanotags in the context of bioimaging and theranostics.

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Section: Multimodal Imaging and Theranostic Applicationsmentioning

confidence: 99%

Design and synthesis of gold nanostars-based SERS nanotags for bioimaging applications

Andreiuk¹,

Nicolson²,

Clark³

et al. 2022

Nanotheranostics

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“…For real-time in vivo imaging, the Raman signal intensity needs to be significantly amplified, which can be achieved with the use of exogenous contrast agents that provide more intense spectra than the intrinsic Raman signal. [24][25][26][27][28][29] These contrast agents typically comprise plasmonic nanoparticle cores, Raman reporter molecules, dielectric shells, and ligands against specific targets, or other functional moieties, as shown in Fig. 1.…”

Section: Principles Of Raman Scattering Surface Enhanced Raman Scattering (Sers) and Surface Enhanced Resonance Raman Scattering (Serrs)mentioning

confidence: 99%

Advances in Surface Enhanced Raman Spectroscopy for in Vivo Imaging in Oncology

Kenry¹,

Nicolson²,

Clark³

et al. 2022

Nanotheranostics

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In the last two decades, the application of surface enhanced Raman scattering (SERS) nanoparticles for preclinical cancer imaging has attracted increasing attention. Raman imaging with SERS nanoparticles offers unparalleled sensitivity, providing a platform for molecular targeting, and granting multiplexed and multimodal imaging capabilities. Recent progress has been facilitated not only by the optimization of the SERS contrast agents themselves, but also by the developments in Raman imaging approaches and instrumentation. In this article, we review the principles of Raman scattering and SERS, present advances in Raman instrumentation specific to cancer imaging, and discuss the biological means of ensuring selective in vivo uptake of SERS contrast agents for targeted, multiplexed, and multimodal imaging applications. We offer our perspective on areas that must be addressed in order to facilitate the clinical translation of SERS contrast agents for in vivo imaging in oncology.

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“…To overcome these difficulties, the rational design of plasmonic nanoparticles for higher SERS response is an active area of research. Many types of plasmonic nanoparticles have already been reported as labels for in vivo tumor bioimaging including colloidal gold [10,11], nanorods [12], nanostars [13], gap-enhanced Raman tags [14][15][16] and others [8,17]. Recently, a novel type of nanoparticle called petal-like gap-enhanced Raman tags [18] have been suggested as ultrabright labels that can overcome the current bottleneck in the field of SERS-based bioimaging.…”

Section: Introductionmentioning

confidence: 99%

Tumor Phantom with Incorporated SERS Tags: Detectability in a Turbid Medium

et al. 2021

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Surface-enhanced Raman scattering (SERS) tags have proven to be excellent labels for tissue bioimaging because of their low interference from biological matrices, high photostability, and possibility for using as theranostic agents. Although SERS tags are widely used for the imaging of tumors in vivo, in practice, the low contrast of the tag accumulation in the tissue and strong light scattering can significantly affect their detectability. In this work, we studied these effects by using a phantom of tumor tissue with incorporated SERS tags. The phantom is a 2 mm sphere of calcium alginate with incorporated SERS tags at a concentration of 0.625 × 108–2 × 109 cm−3. To simulate the surrounding medium with differing turbidities, the phantom was placed in a 4 mm thick agarose gel containing intralipid at a concentration of 0–1%. SERS bioimaging was carried out using standard backscattering geometry with different light focusing conditions. We found that shielding the phantom with a turbid medium led not only to a decrease in detectability but also to a decrease in the apparent size of the imaging object. Our results can help develop more accurate algorithms for processing SERS data for bioimaging.

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Recent advances in applications of nanoparticles in SERS in vivo imaging

Cited by 59 publications

References 105 publications

Design and synthesis of gold nanostars-based SERS nanotags for bioimaging applications

Design and synthesis of gold nanostars-based SERS nanotags for bioimaging applications

Advances in Surface Enhanced Raman Spectroscopy for in Vivo Imaging in Oncology

Tumor Phantom with Incorporated SERS Tags: Detectability in a Turbid Medium

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