Recent Advances in Applications of Cellulose Derivatives-Based Composite Membranes with Hydroxyapatite

Abstract

The development of novel polymeric composites based on cellulose derivatives and hydroxyapatite represents a fascinating and challenging research topic in membranes science and technology. Cellulose-based materials are a viable alternative to synthetic polymers due to their favorable physico-chemical and biological characteristics. They are also an appropriate organic matrix for the incorporation of hydroxyapatite particles, inter and intramolecular hydrogen bonds, as well as electrostatic interactions being formed between the functional groups on the polymeric chains surface and the inorganic filler. The current review presents an overview on the main application fields of cellulose derivatives/hydroxyapatite composite membranes. Considering the versatility of hydroxyapatite particles, the hybrid materials offer favorable prospects for applications in water purification, tissue engineering, drug delivery, and hemodialysis. The preparation technique and the chemical composition have a big influence on the final membrane properties. The well-established membrane fabrication methods such as phase inversion, electrospinning, or gradual electrostatic assembly are discussed, together with the various strategies employed to obtain a homogenous dispersion of the inorganic particles in the polymeric matrix. Finally, the main conclusions and the future directions regarding the preparation and applications of cellulose derivatives/hydroxyapatite composite membranes are presented.

Nanocellulose Hybrids with Metal Oxides Nanoparticles for Biomedical Applications

“…The surface of the hybrids cultured with Escherichia coli for 72 h was observed using SEM. Neat BC had no inhibition effect on the bacterial Some issues that may arise when preparing hybrid materials by immersing or blending the polymer with previously synthesized inorganic particles include the particle aggregation tendency and their uneven distribution inside the organic matrix [49,50]. Biocompatible nanomaterials with controlled quantity and distribution of ZnO on dry or humid BC membranes were obtained using matrix assisted pulsed laser evaporation (MAPLE) [51].…”

Cellulose Composites with Graphene for Tissue Engineering Applications

“…The residue was aged for 24 h, washed with distilled water and dried in a hot air oven. The resulting GO-HA complex was incorporated in bacterial cellulose matrices by impregnating the wet BC membrane with the GO-HA suspension in ethanol, under continuous stirring for 24 h. Due to the osteoinductive and osteoconductive properties of hydroxyapatite [ 90 ], GO-HA could ensure a higher viability of osteoblasts compared to unmodified GO. The biological characterization was performed on normal (NIH3T3) and osteosarcoma (MG-63) cell lines, and consisted of methyl thiazolyl tetrazolium (MTT) assay and alkaline phosphatase (ALP) activity measuring in culture supernatants.…”

“…Membranes obtained by this procedure have different structural characteristics than electrospun mats. They are usually asymmetric, consisting of dense layer in top and a porous substructure at the bottom [ 90 ]. Ignat et al used phase inversion to developed cellulose acetate membranes reinforced with graphene oxide and carbon nanotubes (CNT).…”

Novel Dopamine-Modified Cellulose Acetate Ultrafiltration Membranes with Improved Separation and Antifouling Performances

“…The membrane material is the main factor to determine the membrane performance. Currently, polymer materials including cellulose and its 3 derivatives (Oprea and Voicu 2020), polysulfone (Liu and Kim 2011), polyolefins (Wang et al 2020) and fluorinated materials (Yu et al 2021) are most widely used in the field of membrane separation technology. However, due to the inherent hydrophobic properties of these membrane materials, they are easily contaminated during ultrafiltration process (Li et al 2015).…”