Recent advances in autofluorescence-free biosensing and bioimaging based on persistent luminescence nanoparticles

Lin, Qiaosong; Li, Zhihao; Yuan, Quan

doi:10.1016/j.cclet.2019.06.016

Cited by 62 publications

(35 citation statements)

References 101 publications

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“…The most likely, carbon quantum dots entered cells due to the clathrin-mediated endocytosis or macropinocytosis pathway, which is the most typical for this type of nanomaterial and was confirmed to occur for the QDs of the size 8 nm [ 23 , 24 ]. The results show that the CQDs enable vital staining of the eukaryotic cells and may constitute an interesting alternative to the commercially available products such as expensive antibodies [ 35 , 36 , 37 , 38 ].…”

Section: Resultsmentioning

confidence: 99%

“…CQDs due to their excellent photoluminescence are used for various cells’ visualization [ 35 , 36 , 37 ]. Affinity to the biological structures can be increased trough NH 2 groups grafting using amines such as 2-ethylenediamine, poly(ethyleneamine) or trimethylamine.…”

Section: Introductionmentioning

confidence: 99%

“…They do not change cells morphology. What is important, low cytotoxicity of the carbon quantum dots is not correlated with the raw material used for their obtainment [ 35 , 36 , 37 ].…”

Section: Introductionmentioning

confidence: 99%

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Facile Synthesis of Surface-Modified Carbon Quantum Dots (CQDs) for Biosensing and Bioimaging

et al. 2020

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Recently, fluorescent probes became one of the most efficient tools for biosensing and bioimaging. Special attention is focused on carbon quantum dots (CQDs), which are characterized by the water solubility and lack of cytotoxicity. Moreover, they exhibit higher photostability comparing to traditional organic dyes. Currently, there is a great need for the novel, luminescent nanomaterials with tunable properties enabling fast and effective analysis of the biological samples. In this article, we propose a new, ecofriendly bottom-up synthesis approach for intelligent, surface-modified nanodots preparation using bioproducts as a raw material. Obtained nanomaterials were characterized over their morphology, chemical structure and switchable luminescence. Their possible use as a nanodevice for medicine was investigated. Finally, the products were confirmed to be non-toxic to fibroblasts and capable of cell imaging.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Facile Synthesis of Surface-Modified Carbon Quantum Dots (CQDs) for Biosensing and Bioimaging

et al. 2020

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“…The emitters are usually served by rare-earth ions, transition metal ions, or main group elements in PLNPs, such as Eu 2+ , Sm 3+ , Cr 3+ , Mn 2+ , Bi 3+ , etc. The luminescent wavelength of PLNPs is mainly determined by their emitters [ 10 , 22 ]. The traps are an energy state that can trap electrons in the forbidden band.…”

Section: Plnps Design Considerationsmentioning

confidence: 99%

Persistent luminescence nanoparticles for cancer theranostics application

et al. 2021

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Persistent luminescence nanoparticles (PLNPs) are unique optical materials that emit afterglow luminescence after ceasing excitation. They exhibit unexpected advantages for in vivo optical imaging of tumors, such as autofluorescence-free, high sensitivity, high penetration depth, and multiple excitation sources (UV light, LED, NIR laser, X-ray, and radiopharmaceuticals). Besides, by incorporating other functional molecules, such as photosensitizers, photothermal agents, or therapeutic drugs, PLNPs are also widely used in persistent luminescence (PersL) imaging-guided tumor therapy. In this review, we first summarize the recent developments in the synthesis and surface functionalization of PLNPs, as well as their toxicity studies. We then discuss the in vivo PersL imaging and multimodal imaging from different excitation sources. Furthermore, we highlight PLNPs-based cancer theranostics applications, such as fluorescence-guided surgery, photothermal therapy, photodynamic therapy, drug/gene delivery and combined therapy. Finally, future prospects and challenges of PLNPs in the research of translational medicine are also discussed.

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“…Recently, there are several good reviews on PLPs (Singh, 2014 ; Liang et al, 2019 ; Lin et al, 2020 ). In these reviews, the luminescence mechanisms, the different kinds of PLPs, the controlled synthesis of persistent luminescence materials, and the design of persistent luminescence nanoprobes for biomedical applications have been systematically reviewed (Lin et al, 2019 ; Ma et al, 2019 ). Whereas, the design of lanthanides-doped PLPs with NIR emissions and their biomedical applications have not been overviewed.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Biomedical Applications of Lanthanides-Doped Persistent Luminescence Phosphors With NIR Emissions

2020

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Persistent luminescence phosphors (PLPs) are largely used in biomedical areas owing to their unique advantages in reducing the autofluorescence and light-scattering interference from tissues. Moreover, PLPs with long-lived luminescence in the near-infrared (NIR) region are able to be applied in deep-tissue bioimaging or therapy due to the reduced light absorption of tissues in NIR region. Because of their abundant election levels and energy transfer channels, lanthanides are widely doped in PLPs for the generation of NIR persistent emissions. In addition, the crystal defects introduced by lanthanides-doping can serves as charge traps in PLPs, which contributes to the enhancement of persistent luminescence intensity and the increase of persistent time. In this paper, the research progress in the synthesis and biomedical applications of lanthanides-doped PLPs with NIR emissions are systematically summarized, which can provide instructions for the design and applications of PLPs in the future.

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Recent advances in autofluorescence-free biosensing and bioimaging based on persistent luminescence nanoparticles

Cited by 62 publications

References 101 publications

Facile Synthesis of Surface-Modified Carbon Quantum Dots (CQDs) for Biosensing and Bioimaging

Facile Synthesis of Surface-Modified Carbon Quantum Dots (CQDs) for Biosensing and Bioimaging

Persistent luminescence nanoparticles for cancer theranostics application

Synthesis and Biomedical Applications of Lanthanides-Doped Persistent Luminescence Phosphors With NIR Emissions

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