Recent advances in biocatalytic derivatization of l-tyrosine

Tan, Xu; Song, Wei; Chen, Xiulai; Li, Liming; Wu, Jing

doi:10.1007/s00253-020-10949-6

Cited by 14 publications

(6 citation statements)

References 76 publications

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“…L-Tyr is a valuable amino acid, which has been widely used for the improvement of mental alertness and memory [1]. In addition, L-Tyr is an important intermediate for drugs in the field of pharmaceutical areas, such as adrenaline, norepinephrine, and dopamine [2].…”

Section: Introductionmentioning

confidence: 99%

Adsorption and Recognition Property of Tyrosine Molecularly Imprinted Polymer Prepared via Electron Beam Irradiation

Miao,

Sang,

Gao

et al. 2023

Polymers

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To realize the selective separation of L-tyrosine (L-Tyr) and avoid the drawbacks of traditional thermal polymerization, electron beam irradiation polymerization was developed for the fabrication of L-Tyr molecularly imprinted polymers (MIPs). Firstly, L-Tyr MIPs were prepared with methacrylic acid and ethylene glycol dimethacrylate and without an initiator. Then, the influence of absorbed dosage and temperature on the adsorption capacity of L-Tyr, as well as the thermodynamic behavior, were investigated. The maximum adsorption capacity of 10.96 mg/g for MIPs was obtained with an irradiation dosage of 340 kGy under 15 °C, and the ΔH0 and ΔS0 of the adsorption process are −99.79 kJ/mol and −0.31 kJ/mol·K, respectively. In addition, the effect of adsorption time on adsorption performance was evaluated under different initial concentrations, and the kinetic behavior was fitted with four different models. Finally, the recognition property of the obtained MIPs was investigated with L-Tyr and two analogues. The obtained MIPs have an imprinting factor of 5.1 and relatively high selective coefficients of 3.9 and 3.5 against L-tryptophan and L-phenylalanine, respectively. This work not only provided an L-Tyr MIP with high adsorption capacity and selectivity but also provided an effective and clean method for the synthesis of MIPs.

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Section: Introductionmentioning

confidence: 99%

Adsorption and Recognition Property of Tyrosine Molecularly Imprinted Polymer Prepared via Electron Beam Irradiation

Miao,

Sang,

Gao

et al. 2023

Polymers

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show abstract

“…It was a crucial component of proteins and a precursor of many aromatic primary and secondary metabolites ( Qian et al, 2019 ). While l -Tyrosine was an aromatic polar amino acid, containing highly reactive α-amino, α-carboxyl and phenolic hydroxyl groups ( Tan, Song, Chen, Liu, & Wu, 2020 ).Under drought and high temperature stress, the accumulation of tyrosine would alleviate the environmental pressure on plants ( Elangovan et al, 2020 ). Gao et al certified that the tyrosine metabolic pathway was involved in membrane lipid and energy metabolism ( Gao et al, 2022 ).…”

Section: Resultsmentioning

confidence: 99%

Metabolic mechanism of nitrogen modified atmosphere storage on delaying quality deterioration of rice grains

Li²,

Yang³

et al. 2022

Food Chemistry: X

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“…L-Tyrosine (meta_231) containing highly active α-amino, α-carboxylic, and phenolic hydroxyl groups, can produce derivatives through a series of derivatization reactions. At the same time, L-Tyrosine supplementation may assist the elderly in maintaining core body temperature in cold environments [ 52 ]. Piperine (meta_453) has a variety of medical effects such as antioxidant, anti-inflammatory, anti-aging and neuroprotection [ 53 ].…”

Section: Discussionmentioning

confidence: 99%

Integrated metabolomic and transcriptomic analysis reveals the regulatory mechanisms of flavonoid and alkaloid biosynthesis in the new and old leaves of Murraya tetramera Huang

Zhou,

Xing,

et al. 2024

BMC Plant Biol

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Background Murraya tetramera Huang is a traditional Chinese woody medicine. Its leaves contain flavonoids, alkaloids, and other active compounds, which have anti-inflammatory and analgesic effects, as well as hypoglycemic and lipid-lowering effects, and anti-tumor effects. There are significant differences in the content of flavonoids and alkaloids in leaves during different growth cycles, but the synthesis mechanism is still unclear. Results In April 2021, new leaves (one month old) and old leaves (one and a half years old) of M. tetramera were used as experimental materials to systematically analyze the changes in differentially expressed genes (DEGs) and differentially accumulated metabolites (DAMs) with transcriptomics and metabolomics technology. This was done to identify the signaling pathways of flavonoid and alkaloid synthesis. The results showed that the contents of total alkaloids and flavonoids in old leaves were significantly higher than those in new leaves. Thirteen flavonoid compounds, three isoflavone compounds, and nineteen alkaloid compounds were identified, and 125 and 48 DEGs related to flavonoid and alkaloid synthesis were found, respectively. By constructing the KEGG (Kyoto Encyclopedia of Genes and Genomes) network of DEGs and DAMs, it was shown that the molecular mechanism of flavonoid biosynthesis in M. tetramera mainly focuses on the “flavonoid biosynthetic pathway” and the “flavonoid and flavonol biosynthetic pathway”. Among them, p-Coumaryl alcohol, Sinapyl alcohol, Phloretin, and Isoquercitrin were significantly accumulated in old leaves, the up-regulated expression of CCR (cinnamoyl-CoA reductase) might promote the accumulation of p-Coumaryl alcohol, upregulation of F5H (ferulate-5-hydroxylase) might promote Sinapyl alcohol accumulation. Alkaloids, including indole alkaloids, pyridine alkaloids, imidazole alkaloids, and quinoline alkaloids, were significantly accumulated in old leaves, and a total of 29 genes were associated with these substances. Conclusions These data are helpful to better understand the biosynthesis of flavonoids and alkaloids in M. tetramera and provide a scientific basis for the development of medicinal components in M. tetramera.

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Recent advances in biocatalytic derivatization of l-tyrosine

Cited by 14 publications

References 76 publications

Adsorption and Recognition Property of Tyrosine Molecularly Imprinted Polymer Prepared via Electron Beam Irradiation

Adsorption and Recognition Property of Tyrosine Molecularly Imprinted Polymer Prepared via Electron Beam Irradiation

Metabolic mechanism of nitrogen modified atmosphere storage on delaying quality deterioration of rice grains

Integrated metabolomic and transcriptomic analysis reveals the regulatory mechanisms of flavonoid and alkaloid biosynthesis in the new and old leaves of Murraya tetramera Huang

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