Recent Advances in Biodegradable and Biocompatible Synthetic Polymers Used in Skin Wound Healing

Abstract

The treatment of skin wounds caused by trauma and pathophysiological disorders has been a growing healthcare challenge, posing a great economic burden worldwide. The use of appropriate wound dressings can help to facilitate the repair and healing rate of defective skin. Natural polymer biomaterials such as collagen and hyaluronic acid with excellent biocompatibility have been shown to promote wound healing and the restoration of skin. However, the low mechanical properties and fast degradation rate have limited their applications. Skin wound dressings based on biodegradable and biocompatible synthetic polymers can not only overcome the shortcomings of natural polymer biomaterials but also possess favorable properties for applications in the treatment of skin wounds. Herein, we listed several biodegradable and biocompatible synthetic polymers used as wound dressing materials, such as PVA, PCL, PLA, PLGA, PU, and PEO/PEG, focusing on their composition, fabrication techniques, and functions promoting wound healing. Additionally, the future development prospects of synthetic biodegradable polymer-based wound dressings are put forward. Our review aims to provide new insights for the further development of wound dressings using synthetic biodegradable polymers.

Comparison of Printable Biomaterials for Use in Neural Tissue Engineering: An In Vitro Characterization and In Vivo Biocompatibility Assessment

“…The in vitro biocompatibility of PLA and PCL has been tested previously by other research groups [22,65,66], but not with the SK-N-AS cell line. In this case, both of these thermoplastics obtained great results of the cell viability index in the in vitro L/D assay at 72 h and 7 days of cell culture, as expected from previous studies [67,68]. The non-toxicity and cell viability index of FF with a neural cell line have been examined here for the first time, obtaining similarly good results as the other biomaterials.…”

Degradable Polymeric Bio(nano)materials and Their Biomedical Applications: A Comprehensive Overview and Recent Updates

“…Among these, polysaccharides such as alginate, cellulose, chitosan, and hyaluronic acid are versatile polymers for the development of formulations against skin infections. The efficacy of these biomacromolecules is related to their enhanced biocompatibility, biodegradability, non-toxic nature, chelation, presence of multifunctional groups, and ease of chemical modification [ 421 , 422 , 423 , 424 , 425 , 426 , 427 , 428 , 429 , 430 , 431 , 432 , 433 ].…”

Pharmaceutical Applications of Biomass Polymers: Review of Current Research and Perspectives

“…Biomass polymers are utilized in wound dressing formulations such as hydrogels, films, hydrocolloids, membranes, and foams. Polysaccharides like HA, cellulose, chitosan, and alginate stand out as adaptable biomacromolecules due to their increased chelation ability, non-toxicity, biodegradability, biocompatibility, multifunctional groups, and simple chemical alteration, making them effective in the management of cutaneous infections [212][213][214][215][216][217][218][219][220].…”