Recent advances in biological membrane-based nanomaterials for cancer therapy

Abstract

Nanomaterials have shown significant advantages in the cancer theranostics, owing to their enhanced permeability and retention effect in tumor and multi-function integration capability. Biological membranes, which are collected from various...

Biomimetic Cell-Derived Nanoparticles: Emerging Platforms for Cancer Immunotherapy

“…The structure of biomimetic cell-derived nanoparticles is a core–shell structure, where the core is the nanoparticles delivering the therapeutic agents to the target site and the shell is the membrane materials extracted from different cells. These resulting biomimetic nanoparticles combine the physical and chemical properties of nanoparticles with the intrinsic properties of natural cell membranes, possessing the capacity to evade the immune system, prolong blood circulation, and actively target diagnostic and therapeutic agents to the targeted sites [ 17 , 18 , 19 , 20 ]. In 2011, Hu et al constructed erythrocyte membrane-camouflaged nanoparticles by co-extruding PLGA polymeric nanoparticles and erythrocyte membrane-derived vesicles [ 23 ].…”

“…In the field of cancer diagnosis and therapy, nanoparticles coated with cell membranes combine the biological functions of cell membranes with the drug-loading capability of engineered core nanoparticles, thereby providing a series of unique advantages ( Figure 1 ), including improved biological interface properties, lower immunogenicity, better biocompatibility, longer circulation, more efficient drug delivery, and elevated active-targeting [ 17 , 18 , 19 , 20 ]. Therefore, biomimetic cell-derived nanoparticles have been applied to the precision delivery of theranostic agents or to directly improve the therapeutic efficacy of cancer immunotherapy.…”

Cell Membrane Biomimetic Nano-Delivery Systems for Cancer Therapy

“…Significant improvements have been made in the biocompatibility and tumor-targeting of the nano-delivery systems. Further research on biomimetic nano-delivery systems for cell membranes, and genetically engineered and hybrid membranes have been developed to enhance the efficacy of cancer therapy [ 35 , 40 ].…”