Recent advances in bioprinting techniques: approaches, applications and future prospects

Li, Jipeng; Chen, Mingjiao; Fan, Xianqun; Zhou, Huifang

doi:10.1186/s12967-016-1028-0

Cited by 487 publications

(387 citation statements)

References 114 publications

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“…[5][6][7] In addition, bioprinting, which involves the placement of cells, proteins and genes on a substrate, is also being conducted in the anticipation of future applications in tissue engineering. 8,9) Future artificial organs and implantable devices are also being designed. 10,11) In the pharmaceutical industry, a new tablet (SPRITAM ® , a rapid disintegrating tablet containing levetiracetam) prepared by 3D printing was approved by the U.S. Food and Drug Administration (FDA) in 2015.…”

mentioning

confidence: 99%

3D Printing Factors Important for the Fabrication of Polyvinylalcohol Filament-Based Tablets

Tagami

Fukushige

Ogawa

et al. 2017

Biological & Pharmaceutical Bulletin

119

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Three-dimensional (3D) printers have been applied in many fields, including engineering and the medical sciences. In the pharmaceutical field, approval of the first 3D-printed tablet by the U.S. Food and Drug Administration in 2015 has attracted interest in the manufacture of tablets and drugs by 3D printing techniques as a means of delivering tailor-made drugs in the future. In current study, polyvinylalcohol (PVA)-based tablets were prepared using a fused-deposition-modeling-type 3D printer and the effect of 3D printing conditions on tablet production was investigated. Curcumin, a model drug/fluorescent marker, was loaded into PVA-filament. We found that several printing parameters, such as the rate of extruding PVA (flow rate), can affect the formability of the resulting PVA-tablets. The 3D-printing temperature is controlled by heating the print nozzle and was shown to affect the color of the tablets and their curcumin content. PVA-based infilled tablets with different densities were prepared by changing the fill density as a printing parameter. Tablets with lower fill density floated in an aqueous solution and their curcumin content tended to dissolve faster. These findings will be useful in developing drug-loaded PVA-based 3D objects and other polymerbased articles prepared using fused-deposition-modeling-type 3D printers. Key words three-dimensional (3D) printing; fused deposition modeling; polyvinylalcohol (PVA); tablet; curcuminThe production of various objects by three-dimensional (3D) printers has developed extensively as the printers have evolved.1,2) 3D printers are used by the creator to rapidly design prototype parts and can thus considerably cut production times and costs. 3D printers have been used to manufacture parts for cars, home electronic devices, aircraft engines, buildings, and for other practical uses. It is speculated that 3D printers have potential for many applications and that the 3D printer market will expand.The medical applications of 3D printers have been expanding and bringing innovation to the field.3) For example, the 3D printing of organs and body parts is used to provide blueprints 4) for surgeons and patients to understand disease sites.5-7) In addition, bioprinting, which involves the placement of cells, proteins and genes on a substrate, is also being conducted in the anticipation of future applications in tissue engineering.8,9) Future artificial organs and implantable devices are also being designed. 10,11) In the pharmaceutical industry, a new tablet (SPRITAM ® , a rapid disintegrating tablet containing levetiracetam) prepared by 3D printing was approved by the U.S. Food and Drug Administration (FDA) in 2015.12) The application of 3D printing in medicine, including tablets, holds promise for made-to-order drugs and removes mass product manufacturing from the production line, although the technology in pharmaceutical industry is still in infancy.13) Moreover, it is predicted that the internet of things (IoT) will increase the future use of 3D printers by reinforcing man...

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mentioning

confidence: 99%

3D Printing Factors Important for the Fabrication of Polyvinylalcohol Filament-Based Tablets

Tagami

Fukushige

Ogawa

et al. 2017

Biological & Pharmaceutical Bulletin

119

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“…Yet there is no sufficient evidence to support the use of these new devices such as biodegradable or drug-eluting stents, it seems feasible in humans giving the case series reported (22). Also, bioprinting technology with 3-D prosthetics has drawn more and more attention as a fabrication methodology for producing scaffolds, cells, tissues and organs, having the advantage of precise control, repeatability and individual design (23).…”

Section: New Techniquesmentioning

confidence: 99%

Tracheobronchomalacia treatment: how far have we come?

2016

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“…These strategies can be classified into three main groups: multi-nozzle rapid prototyping (MNRP), decellularization organ regeneration and combined mold system. Each of them has its own advantages and disadvantages in bioartificial organ manufacturing areas [9][10][11] . An obvious advantage of the MNRP technology is that it can produce bioartificial organs automatically mimicking their natural counterparts using heterogeneous cell types and other biomaterials.…”

Section: Introductionmentioning

confidence: 99%

Progress in organ 3D bioprinting

Fan¹,

Liu²,

Chen³

et al. 2024

IJB

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Three dimensional (3D) printing is a hot topic in today's scientific, technological and commercial areas. It is recognized as the main field which promotes "the Third Industrial Revolution". Recently, human organ 3D bioprinting has been put forward into equity market as a concept stock and attracted a lot of attention. A large number of outstanding scientists have flung themselves into this field and made some remarkable headways. Nevertheless, organ 3D bioprinting is a sophisticated manufacture procedure which needs profound scientific/technological backgrounds/knowledges to accomplish. Especially, large organ 3D bioprinting encounters enormous difficulties and challenges. One of them is to build implantable branched vascular networks in a predefined 3D construct. At present, organ 3D bioprinting still in its infancy and a great deal of work needs to be done. Here we briefly overview some of the achievements of 3D bioprinting technologies in large organ, such as the bone, liver, heart, cartilage and skin, manufacturing.Keywords: organ; 3D bioprinting; bone; heart; liver; cartilage; skin

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Recent advances in bioprinting techniques: approaches, applications and future prospects

Cited by 487 publications

References 114 publications

3D Printing Factors Important for the Fabrication of Polyvinylalcohol Filament-Based Tablets

3D Printing Factors Important for the Fabrication of Polyvinylalcohol Filament-Based Tablets

Tracheobronchomalacia treatment: how far have we come?

Progress in organ 3D bioprinting

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