Recent advances in cell membrane-camouflaged nanoparticles for inflammation therapy

Abstract

During inflammation, inflammatory cells are rapidly recruited to sites of infection or injury, where they cross physiological barriers around the infected site and further infiltrate into the tissues. Other cells, such as erythrocytes, endothelial cells and stem cells, also play prominent roles in host defense and tissue repair. In recent years, nanotechnology has been exploited to deliver drugs to sites of inflammation. For example, nanoparticles camouflaged with a cell membrane are a novel drug-delivery platform that can interact with the immune system and that show great potential for treating inflammation. Encapsulating drugs inside plasma membranes derived from various cells involved in inflammatory processes can be effective against inflammation. This review describes the preparation, characterization, and properties of various types of cell membrane-camouflaged biomimetic nanoparticles. It also summarizes preclinical research into their efficacy against inflammation.

All‐In‐One Biomimetic Nanoplatform Based on Hollow Polydopamine Nanoparticles for Synergistically Enhanced Radiotherapy of Colon Cancer

“…Cancer cell membrane‐camouflaged nanoparticles can achieve active targeting by binding to adhesion molecules on the cell membrane, helping the delivery system locate the tumor site and improving the curative effect. [ 34 ] According to our WB result (Figure 2E), membrane protein expressions (Galectin‐3, Na+/K+‐ATPase, and E‐cadherin) are maintained in the Pt@HP@M. Ex vivo imaging of major organs (heart, liver, spleen, lung, and kidney) and the tumor was also performed at 0.5 and 24 h post‐injection of Pt@HP@M (HCT‐116) (Figure 6C). At 0.5 h post‐injection, Pt@HP@M showed a higher DiR signal at tumor site and liver than that at other organs.…”

“…Cancer cell membrane-camouflaged nanoparticles can achieve active targeting through binding to adhesion molecules on the cell membrane, helping the delivery system to locate the tumor site and improving the curative effect. [34] Metabolomics is defined as qualitative and quantitative assessment of the metabolites (small molecules < 1.5 kDa) in body fluids, and is used widely to recognize biomarkers in cancer recently and has a high potential for clinical application. [35] Metabolites can interact with environmental exposures and influence phenotype closely, especially in multifactorial diseases such as cancer.…”

“…Cancer cell membrane‐camouflaged nanoparticles can achieve active targeting through binding to adhesion molecules on the cell membrane, helping the delivery system to locate the tumor site and improving the curative effect. [ 34 ]…”

COVID-19 inflammation and implications in drug delivery

“…Further, hybridization and emerging genetic engineering technologies can be employed to quantitively and qualitatively change their antigenic profile [ 77 ]. Besides being nanodecoys, this biomimetics have been originally used to camouflage drug-loaded NPs owing to the virtues they offer to the nanomaterial core, involving high biocompatibility and biodegradability, prolonged circulation time, and improved targeting efficiency due to the homing tendency of their cell membrane proteins [ 78 , 86 , 87 ]. Therefore, biomimetic nanodecoys constitute a potential therapeutic strategy against COVID-19 infection ( Fig.…”

“…Neutrophils or polymorphonuclear leukocytes (PMNs) are the most abundant circulating white blood cells. Under the guidance of cytokines and chemokines, PMNs migrate and infiltrate into the site of inflammation within a few minutes [ 87 , 137 ]. Like other immune cells, the extravasation of neutrophils is facilitated by multiple interactions with the endothelium, such as the interaction between intercellular adhesion molecule 1 (ICAM-1) upregulated on the inflamed endothelium and the integrin β2 expressed on neutrophils [ 138 ].…”