Recent advances in celluloses and their hybrids for stimuli-responsive drug delivery

Gunathilake, Thennakoon M. Sampath U.; Ching, Yern Chee; Chuah, Cheng Hock; Rahman, Noorsaadah Abd.; Liou, Nai-Shang

doi:10.1016/j.ijbiomac.2020.05.010

Cited by 56 publications

(21 citation statements)

References 137 publications

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“…The treatment methods for algal cellulose sources essentially incorporate culturing methods and purifications to eliminate the algae cell wall matrix [ 43 ]. Similar to plant cellulose and bacterial cellulose, NCC can be extracted from algae by utilizing acid hydrolysis, enzymatic hydrolysis, and mechanical treatments [ 133 ]. It was reported that the NCC produced from red algae waste through acid hydrolysis has high mechanical performance and good transparency [ 134 ].…”

Section: Types Of Cellulosementioning

confidence: 99%

Recent Progress on Tailoring the Biomass-Derived Cellulose Hybrid Composite Photocatalysts

et al. 2022

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Biomass-derived cellulose hybrid composite materials are promising for application in the field of photocatalysis due to their excellent properties. The excellent properties between biomass-derived cellulose and photocatalyst materials was induced by biocompatibility and high hydrophilicity of the cellulose components. Biomass-derived cellulose exhibited huge amount of electron-rich hydroxyl group which could promote superior interaction with the photocatalyst. Hence, the original sources and types of cellulose, synthesizing methods, and fabrication cellulose composites together with applications are reviewed in this paper. Different types of biomasses such as biochar, activated carbon (AC), cellulose, chitosan, and chitin were discussed. Cellulose is categorized as plant cellulose, bacterial cellulose, algae cellulose, and tunicate cellulose. The extraction and purification steps of cellulose were explained in detail. Next, the common photocatalyst nanomaterials including titanium dioxide (TiO2), zinc oxide (ZnO), graphitic carbon nitride (g-C3N4), and graphene, were introduced based on their distinct structures, advantages, and limitations in water treatment applications. The synthesizing method of TiO2-based photocatalyst includes hydrothermal synthesis, sol-gel synthesis, and chemical vapor deposition synthesis. Different synthesizing methods contribute toward different TiO2 forms in terms of structural phases and surface morphology. The fabrication and performance of cellulose composite catalysts give readers a better understanding of the incorporation of cellulose in the development of sustainable and robust photocatalysts. The modifications including metal doping, non-metal doping, and metal–organic frameworks (MOFs) showed improvements on the degradation performance of cellulose composite catalysts. The information and evidence on the fabrication techniques of biomass-derived cellulose hybrid photocatalyst and its recent application in the field of water treatment were reviewed thoroughly in this review paper.

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Section: Types Of Cellulosementioning

confidence: 99%

Recent Progress on Tailoring the Biomass-Derived Cellulose Hybrid Composite Photocatalysts

et al. 2022

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“…Among different types of nanoparticles, biopolymer nanoparticles such as nanocelluloses are intriguing options for controlled therapeutic delivery applications owing to their stimuli-responsiveness, nontoxic, biocompatibility and biodegradability features. In previous studies, nanocelluloses have been used as carriers for various types of antivirals (Gunathilake et al 2020a ). For example, Zoppe et al ( 2014 ) synthesized nanocelluloses by sulfuric acid hydrolysis to carry multivalent displays of tyrosine sulfate mimetic ligands and tested their efficiency in inhibiting alphavirus infection.…”

Section: Introductionmentioning

confidence: 99%

Enhanced curcumin loaded nanocellulose: a possible inhalable nanotherapeutic to treat COVID-19

et al. 2022

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Graphical abstract Nanocellulose/polyvinyl alcohol/curcumin (CNC/PVA/curcumin) nanoparticles with enhanced drug loading properties were developed by the dispersion of nanocellulose in curcumin/polyvinyl alcohol aqueous medium. Due to the physical and chemical nature of sulphuric acid hydrolyzed nanocellulose and the antiviral properties of curcumin, the possibility of using these nanoparticles as an inhalable nanotherapeutic for the treatment of coronavirus disease 2019 (COVID-19) is discussed. The adsorption of curcumin and PVA into nanocellulose, and the presence of anionic sulphate groups, which is important for the interaction with viral glycoproteins were confirmed by Fourier transform infrared (FTIR) spectroscopy. FESEM images showed that the diameter of nanocellulose ranged from 50 to 100 nm, which is closer to the diameter (60–140 nm) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The solubility of poorly water-soluble curcumin was increased from 40.58 ± 1.42 to 313.61 ± 1.05 mg/L with increasing the PVA concentration from 0.05 to 0.8% (w/v) in aqueous medium. This is a significant increase in the solubility compared to curcumin’s solubility in carboxymethyl cellulose medium in our previous study. The drug loading capacity increased by 22-fold with the addition of 0.8% PVA to the nanocellulose dispersed curcumin solution. The highest drug release increased from 1.25 ± 0.15 mg/L to 17.11 ± 0.22 mg/L with increasing the PVA concentration from 0 to 0.8% in the drug-loaded medium. Future studies of this material will be based on the antiviral efficacy against SARS-CoV-2 and cell cytotoxicity studies. Due to the particulate nature, morphology and size of SARS-CoV-2, nanoparticle-based strategies offer a strong approach to tackling this virus. Hence, we believe that the enhanced loading of curcumin in nanocellulose will provide a promising nano-based solution for the treatment of COVID-19.

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“…Cellulose ethers and esters have played an important role during the development of sustained, controlled release oral dosages as (i) coatings capable of responding to changes in the physiological environment, (ii) semi-permeable membranes that can help controlled release, and (iii) hydrophobic matrices that lower the dissolution rate of the active drug [31]. Cellulose acetate phthalate (CAP) is a physiologically inert and FDAapproved pH-sensitive polymer and has been used for decades for the enteric coating of oral formulations to prevent the premature release of the drugs in the acidic stomach while allowing drug release in the more alkaline medium as the intestine.…”

Section: Introductionmentioning

confidence: 99%

Development and Characterization of pH-Dependent Cellulose Acetate Phthalate Nanofibers by Electrospinning Technique

et al. 2021

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The aim of this work was to obtain pH-dependent nanofibers with an electrospinning technique as a novel controlled release system for the treatment of periodontal disease (PD). Cellulose acetate phthalate (CAP) was selected as a pH-sensitive and antimicrobial polymer. The NF was optimized according to polymeric dispersion variables, polymer, and drug concentration, and characterized considering morphology, diameter, entrapment efficiency (EE), process efficiency (PE), thermal properties, and release profiles. Two solvent mixtures were tested, and CHX-CAP-NF prepared with acetone/ethanol at 12% w/v of the polymer showed a diameter size of 934 nm, a uniform morphology with 42% of EE, and 55% of PE. Meanwhile, CHX-CAP-NF prepared with acetone/methanol at 11% w/v of polymer had a diameter of 257 nm, discontinuous nanofiber morphology with 32% of EE, and 40% of PE. EE and PE were dependent on the polymer concentration and the drug used in the formulation. Studies of differential scanning calorimetry (DSC) showed that the drug was dispersed in the NF matrix. The release profiles of CHX from CHX-CAP-NF followed Fickian diffusion dependent on time (t0.43−0.45), suggesting a diffusion–erosion process and a matrix behavior. The NF developed could be employed as a novel drug delivery system in PD.

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Recent advances in celluloses and their hybrids for stimuli-responsive drug delivery

Cited by 56 publications

References 137 publications

Recent Progress on Tailoring the Biomass-Derived Cellulose Hybrid Composite Photocatalysts

Recent Progress on Tailoring the Biomass-Derived Cellulose Hybrid Composite Photocatalysts

Enhanced curcumin loaded nanocellulose: a possible inhalable nanotherapeutic to treat COVID-19

Development and Characterization of pH-Dependent Cellulose Acetate Phthalate Nanofibers by Electrospinning Technique

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