Recent Advances in Chemistry and Bioactivities of Secondary Metabolites from the Genus Acremonium

Abstract

Acremonium fungi is one of the greatest and most complex genera in Hyphomycetes, comprising 130 species of marine and terrestrial sources. The past decades have witnessed substantial chemical and biological investigations on the diverse secondary metabolites from the Acremonium species. To date, over 600 compounds with abundant chemical types as well as a wide range of bioactivities have been obtained from this genus, attracting considerable attention from chemists and pharmacologists. This review mainly summarizes the sources, chemical structures, and biological activities of 115 recently reported new compounds from the genus Acremonium from December 2016 to September 2023. They are structurally classified into terpenoids (42%), peptides (29%), polyketides (20%), and others (9%), among which marine sources are predominant (68%). Notably, these compounds were primarily screened with cytotoxic, antibacterial, and anti-inflammatory activities. This paper provides insights into the exploration and utilization of bioactive compounds in this genus, both within the scientific field and pharmaceutical industry.

Rutinosides-derived from Sarocladium strictum 6-O-α-rhamnosyl-β-glucosidase show enhanced anti-tumoral activity in pancreatic cancer cells

“…Initially, we evaluated diglycosidase activity in twenty-eight fungal strains of the genera Acremonium and Sarocladium using the flavonoids rutin, diosmin and hesperidin as carbon source. These genera were selected based on their recognition as producers of structurally diverse and pharmacologically active compounds [ 40 ]. Flavonoids inhibited the growth of Acremonium sp.…”