Recent advances in chemistry and bioactivity of Sargentodoxa cuneata

Zhang, Wen; Sun, Cheng‐Peng; Zhou, Shuang; Zhao, Wen‐Yu; Wang, Lin; Sheng, Lingli; Jin, Yi; Liu, Tiantian; Yan, Jing; Ma, Xiaochi; Fang, Bangjiang

doi:10.1016/j.jep.2021.113840

Cited by 24 publications

(13 citation statements)

References 87 publications

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“…Many other phytochemicals such as Sargentodaxa cuneata, Cintelactone A, and rosmarinic acid are also proven to have anti-microbial, antioxidant, and anti-inflammatory activities ( Zhang et al, 2021a ; Zhang et al, 2021c ; Di et al, 2021 ). They have been used for treating various inflammatory-mediated diseases.…”

Section: Therapeutic Approaches In Sepsis-induced Acute Kidney Injurymentioning

confidence: 99%

Sepsis-induced AKI: From pathogenesis to therapeutic approaches

Wang

Chen

et al. 2022

Front. Pharmacol.

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Sepsis is a heterogenous and highly complex clinical syndrome, which is caused by infectious or noninfectious factors. Acute kidney injury (AKI) is one of the most common and severe complication of sepsis, and it is associated with high mortality and poor outcomes. Recent evidence has identified that autophagy participates in the pathophysiology of sepsis-associated AKI. Despite the use of antibiotics, the mortality rate is still at an extremely high level in patients with sepsis. Besides traditional treatments, many natural products, including phytochemicals and their derivatives, are proved to exert protective effects through multiple mechanisms, such as regulation of autophagy, inhibition of inflammation, fibrosis, and apoptosis, etc. Accumulating evidence has also shown that many pharmacological inhibitors might have potential therapeutic effects in sepsis-induced AKI. Hence, understanding the pathophysiology of sepsis-induced AKI may help to develop novel therapeutics to attenuate the complications of sepsis and lower the mortality rate. This review updates the recent progress of underlying pathophysiological mechanisms of sepsis-associated AKI, focuses specifically on autophagy, and summarizes the potential therapeutic effects of phytochemicals and pharmacological inhibitors.

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Section: Therapeutic Approaches In Sepsis-induced Acute Kidney Injurymentioning

confidence: 99%

Sepsis-induced AKI: From pathogenesis to therapeutic approaches

Wang

Chen

et al. 2022

Front. Pharmacol.

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“…Over 110 chemical constituents have been identifi ed from the stem of S. cuneata, (75) the only species of Sargentodoxa, including phenolic acids, phenolic glycosides, lignans, flavones, triterpenoids and others. Sargentodoxa is rich in tannins, which are lacking in other genera of Lardizabalaceae.…”

Section: Sargentodoxamentioning

confidence: 99%

“…In the subfamily Sargentodoxoideae, the genus Sargentodoxa is most commonly used in promoting blood circulation to remove stasis (TRI 2181, β 100), followed by dispelling wind and dampness (TRI 1706, β 100), arthritis (TRI 1290, β 100), traumatic injury (TRI 632, β 100), menoxenia (TRI 632, β 100). The extract and compounds of S. cuneata have a wide spectrum of pharmacological activities, including antimicrobial, antitumor, antiinflammatory, antioxidant, anti-sepsis and anti-arthritis effects, (75) as well as protective activity against cerebrovascular diseases.…”

Section: Lardizabalaceae and Circaeasteraceaementioning

confidence: 99%

Mining Therapeutic Efficacy from Treasure Chest of Biodiversity and Chemodiversity: Pharmacophylogeny of Ranunculales Medicinal Plants

Hao

Zheng

et al. 2022

Chin. J. Integr. Med.

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Ranunculales is an order of angiosperms, containing 7 families, i.e., Ranunculaceae (at least 50 genera, >2,000 species), Berberidaceae (17 genera, 650 species), Menispermaceae (65 genera, >350 species), Lardizabalaceae (9 genera, 50 species), Circaeasteraceae (2 species), Papaveraceae (38 genera, >700 species), and Eupteleaceae (2 species, Appendix 1). Ranunculales belongs to the basal eudicots, in which it is the most basal clade; its widely known members include poppies, barberries, monseed, akebia and buttercupss. The chemodiversity of Ranunculaceae, the fl agship family of Ranunculales, and their correlation with the biodiversity and pharmacotherapy, have been systematically reviewed by us in the context of pharmacophylogeny. (1) In recent years, the research enthusiasm for the other 4 major Ranunculales families has been growing rapidly, as plants of these families also meet human needs for food, fl avours, fragrances, and not the least, medicines during long history. Ranunculales plants form the basis of sophisticated traditional medicine systems, e.g., Chinese medicine (CM) and Ayurveda medical system. (2) These systems of medicine give rise to some important Ranunculalesbased drugs still in use today. (3,4) According to incomplete statistics, 573 Ranunculaceae and 308 Berberidaceae species were in medicinally hot nodes; (4) the therapeutic efficacy of 2 families differed substantially. For instance, up to 361 Chinese Ranunculaceae species are used against musculoskeletal diseases, followed by 321 against hepatic diseases, 242 against circulatory diseases, and 210 against skin diseases, etc.; in contrast, as many as 251 Chinese Berberidaceae species are used against eyesight diseases, followed by 249 against hepatic diseases, 242 against digestive diseases and 90 against oral diseases, etc. Nevertheless, except Ranunculaceae, the

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“…Methyl chlorogenate shows strong radical scavenging ability towards the 2,2′-diphenyl-1-picrylhydrazyl radical (DPPH), superoxide scavenging activity and hydroxyl radical scavenging activity [ 8 , 9 , 10 , 11 ]. Methyl chlorogenate is a potential candidate to be developed as an effective anti-inflammatory agent [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Extraction with Acidified Methanol—An Easy and Effective Method of Methyl Chlorogenate Formation, as Studied by ESI-MS

2022

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Among the different Hawthorn species, Crataegus monogyna seems to be one of the most often used in herbal medicine, and is commercially available. The methanolic extract and the acidified methanol extract of an herbal medicinal product based on Crataegus monogyna inflorescences were analyzed by using high-pressure liquid chromatography/electrospray ionization mass spectrometry (HPLC/ESI-MS). On the basis of m/z of [M-H]− ions and characteristic fragmentation patterns, a number of polyphenolic compounds, namely flavonoids and chlorogenic acids, were identified. It was found that the contents of the acid extract were enriched with methyl chlorogenates showing attractive biochemical properties. Analogous results were obtained for other plant materials, e.g., nectarine kernels. Apart from that, acid extraction had a minor influence on the polyphenolic compounds present in the plants, and thus it did not affect the natural antioxidant values of the plant extracts.

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Recent advances in chemistry and bioactivity of Sargentodoxa cuneata

Cited by 24 publications

References 87 publications

Sepsis-induced AKI: From pathogenesis to therapeutic approaches

Sepsis-induced AKI: From pathogenesis to therapeutic approaches

Mining Therapeutic Efficacy from Treasure Chest of Biodiversity and Chemodiversity: Pharmacophylogeny of Ranunculales Medicinal Plants

Extraction with Acidified Methanol—An Easy and Effective Method of Methyl Chlorogenate Formation, as Studied by ESI-MS

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