Recent advances in Chinese patent medicines entering the international market

Zhang, Bo; Pei, Wenjian; Cai, Pingping; Wang, Zhixue; Qi, Fanghua

doi:10.5582/ddt.2022.01115

Cited by 12 publications

(5 citation statements)

References 74 publications

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“…It is worth noting that in the Grignard reaction of 18, methylmagnesium-d 3 iodide (CD 3 MgI) was conveniently prepared in situ from magnesium powders and trideuteriomethyl iodide (methyl-d 3 iodide), and used in excess to drive the reaction to complete. 30…”

Section: Resultsmentioning

confidence: 99%

Integrated Synthesis of Calcitriol and 26,27-Hexadeutero Calcitriol

Tang,

Cui,

et al. 2024

Pharmaceutical Fronts

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Calcitriol (1α,25-dihydroxyvitamin D3, 1), a classical vitamin D drug, is indicated primarily in the treatment of patients with postmenopausal osteoporosis and renal osteodystrophy. In this study, a practical synthesis of calcitriol (1), from readily available commercial vitamin D2 (5) via hub intermediate 18, has been accomplished in 9% overall yield. This semi-synthetic process embedded four prominent elements of vitamin D chemistry: (1) cheletropic sulfur dioxide (SO2) adduction for the isomerization of the characteristic triene from (5Z,7E) to (5E,7E), or for the protection of the triene for selective ozonolysis of the side chain, and cheletropic extrusion of SO2 from the adduct in ethanolic sodium bicarbonate to retrieve the triene; (2) direct, regio- and stereoselective 1α-hydroxylation of 3β-TBS-protected (5E)-calciferol intermediate 19 using selenium dioxide in the presence of N-methylmorpholine N-oxide as a re-oxidant in a hot mixture of methylene chloride and methanol; (3) nickel(0)-mediated conjugate addition of the 22-iodide 23 to electron-deficient ethyl acrylate followed by Grignard reaction with methylmagnesium bromide to construct the calcitriol side chain; and (4) triplet-sensitized photoisomerization of 26 to access the bioactive (5Z,7E)-triene in calcitriol (1). The high-performance liquid chromatography purities of batches of the synthesized calcitriol (1) were consistently more than 99.9%, with related substances listed in the USP 2023 and EP 11.0 well controlled. This robust process proved amenable to pilot scale-up and industrial production. 26,27-Hexadeutero calcitriol (4), a deuterium-labeled calcitriol derivative, is useful as the internal standard in the bioanalysis for the quantification of calcitriol in serum. 4 was efficiently synthesized in an integrated manner from hub intermediate 18 in 48% yield.

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Section: Resultsmentioning

confidence: 99%

Integrated Synthesis of Calcitriol and 26,27-Hexadeutero Calcitriol

Tang,

Cui,

et al. 2024

Pharmaceutical Fronts

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“…TCM, especially Chinese Patent Medicines (CPMs), constitute a fundamental aspect of healthcare in China, playing a pivotal role in disease prevention and treatment [15]. The quality of CPMs is intrinsically linked to their effectiveness [16].…”

Section: Quality Control Of Chinese Patent Medicinesmentioning

confidence: 99%

The Application of Artificial Intelligence in the Research and Development of Traditional Chinese Medicine

Ke,

Liu,

Liu

et al. 2024

IJDDP

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Review The Application of Artificial Intelligence in the Research and Development of Traditional Chinese Medicine Zhipeng Ke 1,2, Minxuan Liu 1,2,3, Jing Liu 1,2, Zhenzhen Su 1,2, Lu Li 1,2, Mengyu Qian 1,2, Xinzhuang Zhang 1,2, Tuanjie Wang 1,2, Liang Cao 1,2, Zhenzhong Wang 1,2, and Wei Xiao 1,2, * 1 National Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture, Lianyungang 222106, China 2 Jiangsu Kanion Pharmaceutical Co., Ltd, Lianyungang 222104, China 3 ‍School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210009, China * Correspondence: xw_kanion@163.com Received: 4 September 2023 Accepted: 4 November 2023 Published: 6 March 2024 Abstract: With the accumulation of data in the pharmaceutical industry and the development of artificial intelligence technology, various artificial intelligence methods have been successfully employed in the drug discovery process. The integration of artificial intelligence in Traditional Chinese medicine has also gained momentum, encompassing quality control of Chinese patent medicines, prescriptions optimization, discovery of effective substances, and prediction of side effects. However, artificial intelligence also faces challenges and limitations in Traditional Chinese medicine development, such as data scarcity and complexity, lack of interdisciplinary professionals, black-box models, etc. Therefore, more research and collaboration are needed to address these issues and explore the best ways to integrate artificial intelligence and Traditional Chinese medicine to improve human health.

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“…Furthermore, the global focus on health and wellness amplifies the marketability of these gels, presenting opportunities for brands to establish a strong presence both domestically and internationally [157]. Patents, serving as a testament to the products' ingenuity, not only protect intellectual property but also provide a solid foundation for effective marketing strategies, ensuring their visibility and credibility in the commercial landscape [158].…”

Section: Commercial Potential Of Patented Plant-derived Medicinal Oil...mentioning

confidence: 99%

Transforming Medicinal Oil into Advanced Gel: An Update on Advancements

Maurya,

Misro,

Boini

et al. 2024

Gels

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The present study delves into the evolution of traditional Ayurvedic oil preparations through innovative strategies to develop advanced gel formulations, aiming at amplifying their therapeutic efficacy. Ayurvedic oils have a rich historical context in healing practices, yet their conversion into contemporary gel-based formulations represents a revolutionary approach to augment their medicinal potential. The primary objective of this transformation is to leverage scientific advancements and modern pharmaceutical techniques to enhance the application, absorption, and overall therapeutic impact of these traditional remedies. By encapsulating the essential constituents of Ayurvedic oils within gel matrices, these novel strategies endeavor to improve their stability, bioavailability, and targeted delivery mechanisms. This review highlights the fusion of traditional Ayurvedic wisdom with cutting-edge pharmaceutical technology, paving the way for more effective and accessible utilization of these revered remedies in modern healthcare.

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Recent advances in Chinese patent medicines entering the international market

Cited by 12 publications

References 74 publications

Integrated Synthesis of Calcitriol and 26,27-Hexadeutero Calcitriol

Integrated Synthesis of Calcitriol and 26,27-Hexadeutero Calcitriol

The Application of Artificial Intelligence in the Research and Development of Traditional Chinese Medicine

Transforming Medicinal Oil into Advanced Gel: An Update on Advancements

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