Recent advances in curcumin-based nanoformulations in diabetes

Ataei, Mahshid; Gumpricht, Eric; Kesharwani, Prashant; Jamialahmadi, Tannaz; Sahebkar, Amirhossein

doi:10.1080/1061186x.2023.2229961

Cited by 9 publications

(2 citation statements)

References 72 publications

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“…Turmeric ( Curcuma longa L.), a traditional Chinese medicine, possesses anti-inflammatory properties attributed to its polyphenol curcuminoids (Panknin et al, 2023 ). Curcumin, a polyphenolic compound derived from the plant Curcuma longa , has been used for the treatment of many diseases, including cardiovascular disease, diabetes, and autoimmune diseases (Zhang & Zeng, 2019 ; Yaribeygi et al, 2023 ; Ataei et al, 2023 ; Kou et al, 2023 ). It has anti-inflammatory and anti-proliferative properties (Razali et al, 2022 ; Luo et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Analysis of the mechanism of curcumin against osteoarthritis using metabolomics and transcriptomics

Deng,

He,

Zhang

2023

Naunyn-Schmiedeberg's Arch Pharmacol

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Curcumin, a polyphenolic compound derived from the turmeric plant (Curcuma longa), has been extensively studied for its anti-inflammatory and anti-proliferative properties. The safety and efficacy of curcumin have been thoroughly validated. Nevertheless, the underlying mechanism for treating osteoarthritis remains ambiguous. This study aims to reveal the potential mechanism of curcumin in treating osteoarthritis by using metabolomics and transcriptomics. Firstly, we validated the effect of curcumin on inflammatory factors in human articular chondrocytes. Secondly, we explored the cellular metabolism mechanism of curcumin against osteoarthritis using cell metabolomics. Thirdly, we assessed the differences in gene expression of human articular chondrocytes through transcriptomics. Lastly, to evaluate the essential targets and elucidate the potential mechanism underlying the therapeutic effects of curcumin in osteoarthritis, we conducted a screening of the proteins within the shared pathway of metabolomics and transcriptomics. Our results demonstrated that curcumin significantly decreased the levels of inflammatory markers, such as IL-β, IL-6, and TNF-α, in human articular chondrocytes. Cell metabolomics identified 106 differential metabolites, including beta-aminopropionitrile, 3-amino-2-piperidone, pyrrole-2-carboxaldehyde, and various other components. The transcriptomic analysis yielded 1050 differential mRNAs. Enrichment analysis showed that the differential metabolites and mRNAs were significantly enriched in seven pathways, including glycine, serine, and threonine metabolism; pentose and glucuronate interconversions; glycerolipid metabolism; histidine metabolism; mucin-type o-glycan biosynthesis; inositol phosphate metabolism; and cysteine and methionine metabolism. A total of 23 key targets were identified to be involved in these pathways. We speculate that curcumin may alleviate osteoarthritis by targeting key proteins involved in glycine, serine, and threonine metabolism; inhibiting pyruvate production; and modulating glycolysis.

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Section: Introductionmentioning

confidence: 99%

Analysis of the mechanism of curcumin against osteoarthritis using metabolomics and transcriptomics

Deng,

He,

Zhang

2023

Naunyn-Schmiedeberg's Arch Pharmacol

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“…Curcumin is a natural polyphenol found in turmeric. Its clinical potential is determined by anti-inflammatory [ 28 ], antimicrobial [ 29 ], anticarcinogenic [ 30 , 31 ], hypoglycemic [ 32 , 33 ] and immunomodulating [ 34 ] and other properties. Curcumin has a very promising property, namely increased uptake by tumor cells in vitro.…”

Section: Introductionmentioning

confidence: 99%

Toxicity Evaluation and Controlled-Release of Curcumin-Loaded Amphiphilic Poly-N-vinylpyrrolidone Nanoparticles: In Vitro and In Vivo Models

Luss,

Bagrov,

Yagolovich

et al. 2023

Pharmaceutics

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Curcumin attracts huge attention because of its biological properties: it is antiproliferative, antioxidant, anti-inflammatory, immunomodulatory and so on. However, its usage has been limited by poor water solubility and low bioavailability. Herein, to solve these problems, we developed curcumin-loaded nanoparticles based on end-capped amphiphilic poly(N-vinylpyrrolidone). Nanoparticles were obtained using the solvent evaporation method and were characterized by dynamic and electrophoretic light scattering, transmission electron (TEM) and atomic force (AFM) microscopy. The average particle size was 200 nm, and the ζ-potential was −4 mV. Curcumin-release studies showed that nanoparticles are stable in aqueous solutions. An in vitro release study showed prolonged action in gastric, intestinal and colonic fluids, consistently, and in PBS. In vitro studies on epidermoid carcinoma and human embryonic kidney cells showed that the cells absorbed more curcumin in nanoparticles compared to free curcumin. Nanoparticles are safe for healthy cells and show high cytotoxicity for glioblastoma cells in cytotoxicity studies in vitro. The median lethal dose was determined in an acute toxicity assay on zebrafish and was 23 μM. Overall, the curcumin-loaded nanoparticles seem promising for cancer treatment.

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Curcumin and butyrate induce fibroblast senescence without the emergence of fibrosis biomarkers

Chu,

Joma,

Yong

et al. 2023

Aspects of Molecular Medicine

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Recent advances in curcumin-based nanoformulations in diabetes

Cited by 9 publications

References 72 publications

Analysis of the mechanism of curcumin against osteoarthritis using metabolomics and transcriptomics

Analysis of the mechanism of curcumin against osteoarthritis using metabolomics and transcriptomics

Toxicity Evaluation and Controlled-Release of Curcumin-Loaded Amphiphilic Poly-N-vinylpyrrolidone Nanoparticles: In Vitro and In Vivo Models

Curcumin and butyrate induce fibroblast senescence without the emergence of fibrosis biomarkers

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