Recent advances in developing modified C14 side chain pleuromutilins as novel antibacterial agents

Liu, Yue; Zhou, Qinjiang; Huo, Yiwen; Sun, Xiujuan; Hu, Jinxing

doi:10.1016/j.ejmech.2024.116313

European Journal of Medicinal Chemistry

2024

DOI: 10.1016/j.ejmech.2024.116313

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Recent advances in developing modified C14 side chain pleuromutilins as novel antibacterial agents

Yue Liu,

Qinjiang Zhou,

Yiwen Huo

et al.

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2024

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Antibacterial and Antifungal Activity of Metabolites from Basidiomycetes: A Review

Lysakova,

Krasnopolskaya,

Yarina

et al. 2024

Antibiotics

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Background/Objectives: The search for new antimicrobial molecules is important to expand the range of available drugs, as well as to overcome the drug resistance of pathogens. One of the promising sources of antibacterial and antifungal metabolites is basidial fungi, which have wide biosynthetic capabilities. Methods: The review summarized the results of studying the antimicrobial activity of extracts and metabolites from basidiomycetes published from 2018–2023. Results: In all studies, testing for antibacterial and antifungal activity was carried out in in vitro experiments. To obtain the extracts, mainly the fruiting bodies of basidiomycetes, as well as their mycelia and culture liquid were used. Antimicrobial activity was found in aqueous, methanol, and ethanol extracts. Antimicrobial metabolites of basidiomycetes were isolated mainly from the submerged culture of basidiomycetes. Metabolites active against Gram-positive and Gram-negative bacteria and mycelial and yeast-like fungi were identified. Conclusions: Basidiomycete extracts and metabolites have shown activity against collectible strains of bacteria and fungi and multi-resistant and clinical strains of pathogenic bacteria. The minimum inhibitory concentration (MIC) values of the most active metabolites ranged from 1 to 16.7 µg/mL.

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Antibacterial and Antifungal Activity of Metabolites from Basidiomycetes: A Review

Lysakova,

Krasnopolskaya,

Yarina

et al. 2024

Antibiotics

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show abstract

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Recent advances in developing modified C14 side chain pleuromutilins as novel antibacterial agents

Cited by 1 publication

References 78 publications

Antibacterial and Antifungal Activity of Metabolites from Basidiomycetes: A Review

Antibacterial and Antifungal Activity of Metabolites from Basidiomycetes: A Review

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