Drinking and wastewater are to be treated for safe human consumption and for keeping surface waters clean. There are multiple water purification procedures, but the use of ion-exchange resins significantly enhances water purification efficiency. This review was targeted on highlighting the concept and classification of polymeric ion-exchange resins as well as pointing out their real-world applications. Their successful use for purification purposes has been linked to their chemical structure, simplicity of operation, accessibility, and reusability. Therefore, polymeric ion-exchange resins have been used for the removal of a wide range of organic and inorganic pollutants such as pharmaceutical compounds, dyes, organic matter, metals, and many others. Ion-exchange resins are obtained directly by synthesis methods or grafting ionizable groups on polymer matrix in order to ensure continuous improvement. Furthermore, the newly designed ion-exchange resins take into consideration biodegradability potential towards obtaining ecofriendly compounds.