Recent advances in development of poly (dimethylaminoethyl methacrylate) antimicrobial polymers

Kanth, Shreya; Puttaiahgowda, Yashoda Malgar; Nagaraja, Akshatha; Bukva, Merima

doi:10.1016/j.eurpolymj.2021.110930

Cited by 15 publications

(11 citation statements)

References 137 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All these structural elements contribute to determining their antimicrobial potential against bacterial species growing planktonically or forming a biofilm [ 28 ]. Research to date suggests that the mechanism of action of such compounds relies on severe perturbations of the cell membrane and alteration of their physiological fluidity, which lead to protein membrane instability, causing the malfunctioning of their transport and energy-transducing systems, sensing, signal transductions, migration, and adhesion among others [ 29 , 30 ]. Alkyl chain length is a structural element that strongly influences the antimicrobial potential of QASs.…”

Section: Resultsmentioning

confidence: 99%

Antifouling Systems Based on a Polyhedral Oligomeric Silsesquioxane-Based Hexyl Imidazolium Salt Adsorbed on Copper Nanoparticles Supported on Titania

Presentato¹,

Greca

Consentino

et al. 2023

Nanomaterials

View full text Add to dashboard Cite

The reaction of octakis(3-chloropropyl)octasilsesquioxane with four equivalents of 1-hexylimidazole or 1-decylimidazole gave two products labelled as HQ-POSS (hexyl-imidazolium quaternized POSS) and DQ-POSS (decyl-imidazolium quaternized POSS) as regioisomer mixtures. An investigation of the biological activity of these two compounds revealed the higher antimicrobial performances of HQ-POSS against Gram-positive and Gram-negative microorganisms, proving its broad-spectrum activity. Due to its very viscous nature, HQ-POSS was adsorbed in variable amounts on the surface of biologically active oxides to gain advantages regarding the expendability of such formulations from an applicative perspective. Titania and 5 wt% Cu on titania were used as supports. The materials 10HQ-POSS/Ti and 15HQ-POSS/5CuTi strongly inhibited the ability of Pseudomonas PS27 cells—a bacterial strain described for its ability to handle very toxic organic solvents and perfluorinated compounds—to grow as planktonic cells. Moreover, the best formulations (i.e., 10HQ-POSS/Ti and 15HQ-POSS/5CuTi) could prevent Pseudomonas PS27 biofilm formation at a certain concentration (250 μg mL−1) which greatly impaired bacterial planktonic growth. Specifically, 15HQ-POSS/5CuTi completely impaired cell adhesion, thus successfully prejudicing biofilm formation and proving its suitability as a potential antifouling agent. Considering that most studies deal with quaternary ammonium salts (QASs) with long alkyl chains (>10 carbon atoms), the results reported here on hexylimidazolium-based POSS further deepen the knowledge of QAS formulations which can be used as antifouling compounds.

show abstract

Section: Resultsmentioning

confidence: 99%

Antifouling Systems Based on a Polyhedral Oligomeric Silsesquioxane-Based Hexyl Imidazolium Salt Adsorbed on Copper Nanoparticles Supported on Titania

Presentato¹,

Greca

Consentino

et al. 2023

Nanomaterials

View full text Add to dashboard Cite

show abstract

“…Despite several PDMAEMA‐based AMPs that have been reported, 53, 54 there is no example of the preparation of star‐shaped PDMAEMA copolymers prepared by arm‐first RAFT polymerization. It is noteworthy that both PDMAEMA and PCDMA were chosen as models due to their antimicrobial character, as already published elsewhere 55, 56 . Herein, we combined these biocides in a unique molecule and tested its potential bioactivity.…”

Section: Resultsmentioning

confidence: 99%

“…Figure 6 (c) shows a quantity of debris from killed bacteria with the morphology completely collapsed, showing effective antimicrobial action. 59 As documented, cationic PDMAEMA-based (co)polymers interact with the negatively charged bacterial cell wall, ultimately resulting in the leakage of cytoplasmic materials, 55 therefore presenting a contact-killing mechanism. In addition, the antibacterial mechanism of the polymer via membrane disruption was proven by live/dead bacterial viability assays; fluorescence images (Fig.…”

Section: Sem Imaging Of E Colimentioning

confidence: 99%

“…It is noteworthy that both PDMAEMA and PCDMA were chosen as models due to their antimicrobial character, as already published elsewhere. 55,56 Herein, we combined these biocides in a unique molecule and tested its potential bioactivity. For this, we chose the 12-arm PDMAEMA 40 -co-PCDMA 4 copolymer and assessed it against Gram-negative E. coli.…”

Section: Antimicrobial Activitymentioning

confidence: 99%

See 1 more Smart Citation

Amphiphilic star copolymers composed of curcumin core for bacterial inactivation

Santos,

Fidelis,

Zandonadi

et al. 2023

Polymer International

View full text Add to dashboard Cite

Polymeric materials with antimicrobial properties hold the potential to be the next generation of therapeutics. This work reports the preparation of amphiphilic and star‐like copolymers through arm‐first and reversible addition–fragmentation chain transfer polymerization. The copolymers composed of poly(dimethylamine ethyl methacrylate) (PDMAEMA) as the arms and poly(curcumin dimethacrylate) (PCDMA) as the crosslinked core presented a well‐controlled amphiphilic structure with low dispersity values (Ð = 1.15). Varying the [CDMA]:[PDMAEMA] molar ratios (4, 6 and 8) led to a significant increase in the molar mass (153, 688 and 1550 kDa), particle size (33, 90 and 105 nm) and the average number of PDMAEMA arms anchored to the curcumin‐based core (12, 52 and 125 arms), as determined by dynamic and static light scattering. The antimicrobial activity of cationic PDMAEMA40‐co‐PCDMAcore was tested against Escherichia coli in the absence of light and under white light to investigate the photodynamic activity of the copolymers. The results demonstrated a concentration dependence but no additional effect under light irradiation. SEM imaging and live/dead assays revealed extensive membrane damage, evidencing a membrane‐disruption mechanism. HeLa viability assays demonstrated that at 1 mg mL−1, 80 ± 10% of the cells demonstrated metabolic activity after 24 h. © 2023 Society of Industrial Chemistry.

show abstract

“…Poly [2-(dimethylamino)ethylmethacrylate (PDMAEMA) has also been found to be a prospective candidate for antibacterial purposes. It possesses a tertiary amino group in its side chain and easily could be quaternized to quaternary ammonium compound [ 99 , 100 ]. In both forms, PDMAEMA exhibits good antimicrobial effects on a wide spectrum of Gram-negative and Gram-positive strains [ 69 , 99 , 100 ].…”

Section: Nanomaterials Against Biofilm-related Infectionsmentioning

confidence: 99%

An Overview of Biofilm-Associated Infections and the Role of Phytochemicals and Nanomaterials in Their Control and Prevention

Damyanova,

Dimitrova,

Borisova

et al. 2024

Pharmaceutics

View full text Add to dashboard Cite

Biofilm formation is considered one of the primary virulence mechanisms in Gram-positive and Gram-negative pathogenic species, particularly those responsible for chronic infections and promoting bacterial survival within the host. In recent years, there has been a growing interest in discovering new compounds capable of inhibiting biofilm formation. This is considered a promising antivirulence strategy that could potentially overcome antibiotic resistance issues. Effective antibiofilm agents should possess distinctive properties. They should be structurally unique, enable easy entry into cells, influence quorum sensing signaling, and synergize with other antibacterial agents. Many of these properties are found in both natural systems that are isolated from plants and in synthetic systems like nanoparticles and nanocomposites. In this review, we discuss the clinical nature of biofilm-associated infections and some of the mechanisms associated with their antibiotic tolerance. We focus on the advantages and efficacy of various natural and synthetic compounds as a new therapeutic approach to control bacterial biofilms and address multidrug resistance in bacteria.

show abstract

Recent advances in development of poly (dimethylaminoethyl methacrylate) antimicrobial polymers

Cited by 15 publications

References 137 publications

Antifouling Systems Based on a Polyhedral Oligomeric Silsesquioxane-Based Hexyl Imidazolium Salt Adsorbed on Copper Nanoparticles Supported on Titania

Antifouling Systems Based on a Polyhedral Oligomeric Silsesquioxane-Based Hexyl Imidazolium Salt Adsorbed on Copper Nanoparticles Supported on Titania

Amphiphilic star copolymers composed of curcumin core for bacterial inactivation

An Overview of Biofilm-Associated Infections and the Role of Phytochemicals and Nanomaterials in Their Control and Prevention

Contact Info

Product

Resources

About