Recent advances in development of anthelmintic agents: Synthesis and biological screening

Bhavsar, Zeel A.; Acharya, Prachi T.; Jethava, Divya J.; Patel, Hitesh

doi:10.1080/00397911.2019.1695276

Cited by 21 publications

(6 citation statements)

References 84 publications

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“…Piperazine was firstly developed during 19 th century and it has more potency against helminthic infection /threadworm infection in small children as it is non-prescription medication. Diethyl carbamazepine drug have been used in intestinal nematode infection but its mechanism of action is still unknown hence it is withdrawn from the market 10,11,12,13,14,15 .…”

Section: General Properties Of Heterocyclic Compoundmentioning

confidence: 99%

Untitled

2024

IJPSR

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Organic chemist has developed the number of heterocyclic compounds. The heterocyclic compounds have gained more attention in medicinal and organic chemistry because of their numerous biological activities. There are various types of the heterocyclic compound available for several biological activities such as antibacterial activity, anticancer activity, antiepileptic activity, antipsychotic activity, antihypertensive activity, antiproliferative activity. Pyrrole, furan, benzimidazole, thiophenol, thiophene, imidazole and indole compounds became more popular heterocyclic compound due to their biological activities, betalactam ring system has important role in the design of different antibiotics as well as in the biological activities. Furthermore the recent advancement that occurred in the scheme of heterocyclic compound caught more attention in many product developments. The present review article focused on the heterocyclic compound, classification, nomenclature, importance of heterocyclic compound, history of heterocyclic compound and recent development in the scheme along with their biological activities.

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Section: General Properties Of Heterocyclic Compoundmentioning

confidence: 99%

Untitled

2024

IJPSR

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“…Warfarin, brodifacoum, dicumarol, coumatetralyl, coumafuryl, and difenacoum are well-known examples of current drugs molecules that possess 4-hydroxy coumarin as a core structural moiety. − Moreover, wedelolactone, coumestrol, and neo-tanshinlactone are emerging potential candidates to this end that revealed promising activities (Figure ). , Recently, trans -2,3-dihydrofuro[3,2- c ]coumarins (DHFCs) (derivatives of 4-hydroxy coumarin) are of great interest among coumarins possessing a unique 4 H -furo ring fused with coumarin, which are well-known for their medicinal importance, therapeutic activities, and applications in myriad pharmaceutical ingredients. , Several drug candidates containing the furo[3,2- c ]coumarin and DHFC skeleton display an extremely wide range of biological activities such as anticoagulant, antibacterial, antifungal, antitumor, antiviral, anticonvulsant, anticancer, antimicrobial, antiprotozoal, insecticidal, fungicidal, antimycobacterial, antimutagenic, antioxidant, and anti-inflammatory. − For instance, natural products austocystin A and D and neo-tanshinlactone isolated from the maize meal cultures of Aspergillus ustus and Salvia miltiorrhiza, respectively, displayed potent antitumor activities and cytotoxicity against breast cancer. , In addition, naphthalene-functionalized DHFCs are known as antioxidant and anthelmintic agents …”

Section: Introductionmentioning

confidence: 99%

“… 23 , 24 In addition, naphthalene-functionalized DHFCs are known as antioxidant and anthelmintic agents. 25 …”

Section: Introductionmentioning

confidence: 99%

Effective Synthesis and Biological Evaluation of Functionalized 2,3-Dihydrofuro[3,2-c]coumarins via an Imidazole-Catalyzed Green Multicomponent Approach

et al. 2022

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For the first time, an eco-friendly and efficient onepot green multicomponent approach has been described to synthesize functionalized trans-2, 3-dihydrofuro[3,2-c]coumarins (DHFCs). In this synthesis, imidazole and water were used as the catalyst and solvent, respectively, under mild conditions. Applications of the developed catalytic process in a water medium revealed the outstanding activity, productivity, and broad functional group tolerance, affording a series of newly designed DHFC and derivatives in excellent yields (72−98%). Moreover, the human serum albumin (HSA) binding ability of the synthesized DHFC derivatives has been uncovered through the detailed in silico and in vitro-based structure-activity analysis. The ability to bind HSA, the most abundant serum protein, in the low micromolar ranges unequivocally reflects the suitable absorption, distribution, metabolism, and elimination profile of the synthesized compounds, which may further be envisaged for their therapeutic usage endeavors.

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“…In their research, many scientists have developed an important variety of bioactive heterocyclic molecules. Between these, sulfur and nitrogencontaining compounds, such as thiosemicarbazides, have received significant attention, due to their tuberculostatic activity, in particular [2][3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Optimized Synthesis of New Thiosemicarbazide Derivatives with Tuberculostatic Activity

Popovici

Pavel

Şunel

et al. 2021

IJMS

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Original results are presented in the field of research that addresses the extension of the reaction of residue of acyl-thiosemicarbazide fixation on the structure of 5-nitrobenzimidazole by a sulphonic group. The aim of the study is the increase of new thiosemicarbazide derivatives’ applicative potential in the field of biochemistry, with a wide range of medical applications. The newly obtained compounds were characterized by using elemental analysis and spectral analysis (FT-IR and 1H NMR). A study regarding the optimization of the chemical reactions was made. The performed in vitro biological tests confirmed the tuberculostatic activity of three newly obtained compounds against Mycobacterium tuberculosis.

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Recent advances in development of anthelmintic agents: Synthesis and biological screening

Cited by 21 publications

References 84 publications

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Effective Synthesis and Biological Evaluation of Functionalized 2,3-Dihydrofuro[3,2-c]coumarins via an Imidazole-Catalyzed Green Multicomponent Approach

Optimized Synthesis of New Thiosemicarbazide Derivatives with Tuberculostatic Activity

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