Recent advances in diagnosing and managing nut allergies with focus on hazelnuts, walnuts, and cashew nuts

Borres, Magnus P.; Sato, Sakura; Ebisawa, Motohiro

doi:10.1016/j.waojou.2022.100641

Cited by 23 publications

(18 citation statements)

References 81 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although there are recent reviews on the management and diagnosis of tree nut allergy [44][45][46][47][48] , this is the first systematic review thoroughly investigating the available information on therapeutic options for the desensitization of patients with IgE-mediated tree nut allergy, other than peanut.…”

Section: Discussionmentioning

confidence: 99%

Title: Current options in the management of tree nut allergy, focusing on, but not limited to immunotherapy: A systematic review.

Pasioti

Xepapadaki

Mathioudakis

et al. 2022

Preprint

View full text Add to dashboard Cite

This systematic review evaluates the potential therapeutic options for desensitization of patients with IgE-mediated tree nut allergy, focusing, but not limited to, on immunotherapy. We searched three bibliographic databases for studies published until July 2022 for active treatments of IgE-mediated allergy to tree nuts (walnut, hazelnut, pistachio, cashew, and almond) with allergen-specific immunotherapy (AIT) using oral (OIT), sublingual (SLIT), epicutaneous (EPIT) or subcutaneous (SCIT) delivery, or with other disease-modifying treatments. We included 26 studies, but the heterogeneity of the studies prevented pooling and meta-analysis. Immunotherapy with hazel pollen extracts might benefit patients with a secondary nut allergy due to cross-reactivity with PR-10 or profilin panallergens but is unlikely to be beneficial in patients with a severe nut allergy caused by seed storage proteins. Sublingual immunotherapy has a moderate efficacy but a favorable safety profile. Oral immunotherapy (OIT), single, or multi-nut, with or without omalizumab, is the most studied approach. In general, tree nut OIT is effective in conferring protection from accidental exposures, with safety similar to that demonstrated by peanut OIT. The observed cross-desensitization between tree nuts straightly affects the management options for multi-nut allergic patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Title: Current options in the management of tree nut allergy, focusing on, but not limited to immunotherapy: A systematic review.

Pasioti

Xepapadaki

Mathioudakis

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Of note is that class II food allergy is associated with sensitization to pollen allergens [ 41 ]. In the case of hazelnut, for example, there is a similarity in protein sequence between the Bet v 1 allergen in birch pollen and the Cor a 1 allergen in hazelnut, which would increase the odds of cross-reactivity [ 42 ]. Cross-reactivity is possible with consuming multiple nut allergens, such as walnuts, pecans, cashews, and pistachios [ 43 ].…”

Section: Allergy Mechanism Of Various Food Allergensmentioning

confidence: 99%

Advances in the Study of Probiotics for Immunomodulation and Intervention in Food Allergy

Huang

Liang

et al. 2023

Molecules

View full text Add to dashboard Cite

Food allergies are a serious food safety and public health issue. Soybean, dairy, aquatic, poultry, and nut products are common allergens inducing allergic reactions and adverse symptoms such as atopic dermatitis, allergic eczema, allergic asthma, and allergic rhinitis. Probiotics are assumed as an essential ingredient in maintaining intestinal microorganisms’ composition. They have unique physiological roles and therapeutic effects in maintaining the mucosal barrier, immune function, and gastrointestinal tract, inhibiting the invasion of pathogenic bacteria, and preventing diarrhea and food allergies. Multiple pieces of evidence reveal a significant disruptive effect of probiotics on food allergy pathology and progression mechanisms. Thus, this review describes the allergenic proteins as an entry point and briefly describes the application of probiotics in allergenic foods. Then, the role of probiotics in preventing and curing allergic diseases by regulating human immunity through intestinal flora and intestinal barrier, modulating host immune active cells, and improving host amino acid metabolism are described in detail. The anti-allergic role of probiotics in the function and metabolism of the gastrointestinal tract has been comprehensively explored to furnish insights for relieving food allergy symptoms and preventing food allergy.

show abstract

“…The exact prevalence of cashew nut allergy is not known. In older studies, 30% of nut-allergic individuals in the USA and 20% in the Netherlands were allergic to cashews (summarized by Borres et al 2022 [ 91 ]). Cashew was also the most common trigger of nut-induced anaphylaxis in Europe [ 50 ].…”

Section: Evaluation Of Plant-based (Substitute) Products With Respect...mentioning

confidence: 99%

“…In a follow-up study, the same research group demonstrated that oral immunotherapy with cashew also resulted in tolerance of all co-sensitized pistachio-allergic patients [ 93 ]. Other cross-reactions have been described to allergens from within citrus seeds (summarized by Borres et al 2022 [ 91 ]), although these must be released first by destruction of the seeds to become clinically relevant. In addition, all patients with allergy to pectin described in the literature were also allergic to cashew seed, although the cross-reactive allergen has not yet been identified.…”

Section: Evaluation Of Plant-based (Substitute) Products With Respect...mentioning

confidence: 99%

Vegan diets from an allergy point of view – Position paper of the DGAKI working group on food allergy

Reese¹,

Schäfer²,

Ballmer‐Weber³

et al. 2023

ALS

View full text Add to dashboard Cite

Vegan diets are currently attracting a great deal of attention. However, avoiding animal-based foods restricts the diet and is associated with risks, the extent and medical implications of which are at present not sufficiently understood. Elimination diets represent the usual therapeutic long-term management in the presence of food allergy. In order to understand the risks of vegan diets and to discuss these critically from the perspective of food allergies, the expertise of a nutritionist/dietitian with expertise in this area is indispensable. This position paper deals with the incentives behind and the benefits of a plant-based diet. The knowledge required to cover macro- and micronutrient dietary requirements is presented. Using the avoidance of cow’s milk as an example, the challenges of adequately meeting nutritional needs are identified and (so-called) milk alternatives are evaluated from an allergy and nutritional point of view. Finally, other plant-based (substitute) products are evaluated from the same perspective, as significant protein sources in vegan diets (e.g., legumes, nuts, and seeds) are at the same time potential and potent triggers of allergic reactions. However, the allergic potential of many substitute products cannot be fully assessed at present due to gaps in research. Wheat as the most important trigger for anaphylaxis in adults is also evaluated. Finally, the increase in ultra-processed products in the (vegan) food sector and their potential consequences for the immune system are discussed.

show abstract

Recent advances in diagnosing and managing nut allergies with focus on hazelnuts, walnuts, and cashew nuts

Cited by 23 publications

References 81 publications

Title: Current options in the management of tree nut allergy, focusing on, but not limited to immunotherapy: A systematic review.

Title: Current options in the management of tree nut allergy, focusing on, but not limited to immunotherapy: A systematic review.

Advances in the Study of Probiotics for Immunomodulation and Intervention in Food Allergy

Vegan diets from an allergy point of view – Position paper of the DGAKI working group on food allergy

Contact Info

Product

Resources

About