Recent advances in direct α-C(sp3)-H bond functionalization of thioethers

Transition-metal-free C–S bond cleavage and transformation of organosulfur compounds

“…Thioethers, as valuable sulfur-containing skeletons, have great potential to undergo a selective C–S bond cleavage to construct various useful organic molecules in pharmaceutical, agricultural and material fields. 2 a , c , d ,7 In the transition metal-catalyzed strategy, the ability of C(sp 2 )–S bond cleavage of the thioether is much better than that of C(sp 3 )–S bond. However, the transition-metal-free strategy is usually chemoselective toward the C(sp 3 )–S bond.…”

Electron Donor‐Acceptor (EDA) Complex Enabled C−C Cross‐Coupling Reactions of α‐Amino Radicals

“…In this context, transition-metal catalysis was proven to be one of the preferred strategies and was applied extensively for the synthesis of many bio-active natural products and pharmacophores. [34][35][36][37][38][39][40] Furthermore, the usage of chiral ligands along with transitionmetal could make the process enantioselective. [41] Later to make the process more economical, metallaphotocatalysis came front where a combination of visible light and transition metal was used to affect the catalytic cycle.…”

Recent developments on 1,2-difunctionalization and hydrofunctionalization of unactivated alkenes and alkynes involving C–S bond formation

“…In recent years, with the continuous efforts being made in the synthesis of sulfur-containing compounds, tremendous breakthroughs have been achieved. 8 It is no exaggeration that the sulfenofunctionalization and hydrosulfenylation of alkenes or alkynes have emerged as a highly efficient tool toward the construction of C–S building blocks. 9 This brief review 10,11 focuses on and highlights the recent progress made in the formation of C–S bonds on the basis of the 1,2-difunctionalization and hydrofunctionalization of unactivated alkenes and alkynes, which are herein classified by the type of active intermediate that initiates the transformations: radical, electrophilic sulfenofunctionalization, and transition-metal catalyzed reactions (Scheme 1B).…”