Recent advances in droplet‐based microfluidics in liquid biopsy for cancer diagnosis

Shi, Jingyu; Zhang, Yu; Fan, Yadi; Liu, Yi; Yang, Mo

doi:10.1002/dro2.92

Cited by 7 publications

(1 citation statement)

References 173 publications

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“…Among various microfluidic single-cell isolation techniques, droplet-based microfluidics have drawn significant attention with applications in scRNA-seq. In this method, individual cells are encapsulated into droplets acting as tiny microchambers [60][61][62][63]. Various microfluidic chip designs for producing microdroplets have been proposed.…”

Section: Droplet-based Microfluidicsmentioning

confidence: 99%

Single-Cell RNA Sequencing in Organ and Cell Transplantation

Abedini-Nassab,

Taheri,

Emamgholizadeh

et al. 2024

Biosensors

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Single-cell RNA sequencing is a high-throughput novel method that provides transcriptional profiling of individual cells within biological samples. This method typically uses microfluidics systems to uncover the complex intercellular communication networks and biological pathways buried within highly heterogeneous cell populations in tissues. One important application of this technology sits in the fields of organ and stem cell transplantation, where complications such as graft rejection and other post-transplantation life-threatening issues may occur. In this review, we first focus on research in which single-cell RNA sequencing is used to study the transcriptional profile of transplanted tissues. This technology enables the analysis of the donor and recipient cells and identifies cell types and states associated with transplant complications and pathologies. We also review the use of single-cell RNA sequencing in stem cell implantation. This method enables studying the heterogeneity of normal and pathological stem cells and the heterogeneity in cell populations. With their remarkably rapid pace, the single-cell RNA sequencing methodologies will potentially result in breakthroughs in clinical transplantation in the coming years.

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Section: Droplet-based Microfluidicsmentioning

confidence: 99%

Single-Cell RNA Sequencing in Organ and Cell Transplantation

Abedini-Nassab,

Taheri,

Emamgholizadeh

et al. 2024

Biosensors

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Tailoring Biopolymers for Electronic Skins: Materials Design and Applications

Zhu,

Wang,

Yang

et al. 2024

Advanced Materials

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The past few years have witnessed the rapid exploration of natural and synthetic materials to construct electronic skins (e‐skins) to emulate the multisensory functions of human skins driven by promising applications. Among various materials employed in functional e‐skins, biopolymers are particularly notable for their exceptional biocompatibility and abundant resources. Despite remarkable progress in engineering biopolymeric materials, a timely and holistic review focusing on the design, synthesis, and modification of biopolymers tailored for biopolymers‐derived e‐skins (Bp‐E‐Skins) is lacking. In this review, the key attributes of biopolymers are introduced to establish a fundamental understanding fordeveloping functional Bp‐E‐Skins. Next, the recent progress in harnessing various natural and synthetic biopolymers as building blocks for constructing Bp‐E‐Skins is systematically discussed, providing insights into maximizing the distinctive attributes of biopolymers. Subsequently, the benefits of nature‐inspired Bp‐E‐Skins achieved through heterogeneous composite and structural engineering are highlighted, infusing fresh momentum into the advancement of e‐skins. Then, the promising applications of Bp‐E‐Skins in multisensory functions are summarized, including both local monitoring and remote teleoperation, as well as sustainable energy harvesting that empowers e‐skins. Finally, the remaining fundamental and technical challenges in advancing Bp‐E‐Skins are presented to provoke future designs that emulate and even go beyond human skins.

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Controllable self‐transport of bouncing droplets on ultraslippery surfaces with wedge‐shaped grooves

Yue,

Dai,

Yang

et al. 2024

Droplet

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Preventing the accretion of droplets on surfaces is vital and slippery liquid‐infused porous surfaces (SLIPS) have promising application prospects, such as surface self‐cleaning and droplet transportation. In this work, controllable self‐transport of bouncing droplets on ultraslippery surfaces with wedge‐shaped grooves is reported. The impact behaviors of droplets on SLIPS under various impact velocities and diameters are explored, which can be classified as hover, total bounce, partial bounce, Worthington jet, and crush. SLIPS with wedge‐shaped grooves were designed to transport accreted droplets. An energy and transport model is established to explain the impact and self‐transport mechanism, where the Laplace pressure and moving resistance between droplets play a key role. Finally, SLIPS with branched wedge‐shaped grooves were designed for droplet self‐transport and demonstrated advantages. This work provides a general reference for spontaneous motion control of sessile droplets, droplets with initial impacting velocity, or even liquid films.

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Recent advances in droplet‐based microfluidics in liquid biopsy for cancer diagnosis

Cited by 7 publications

References 173 publications

Single-Cell RNA Sequencing in Organ and Cell Transplantation

Single-Cell RNA Sequencing in Organ and Cell Transplantation

Tailoring Biopolymers for Electronic Skins: Materials Design and Applications

Controllable self‐transport of bouncing droplets on ultraslippery surfaces with wedge‐shaped grooves

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