Recent advances in drug delivery and targeting for the treatment of pancreatic cancer

Pramanik, Nilkamal; Gupta, Aditya; Ghanwatkar, Yashwardhan; Mahato, Ram I.

doi:10.1016/j.jconrel.2023.12.053

Journal of Controlled Release

2024

DOI: 10.1016/j.jconrel.2023.12.053

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Recent advances in drug delivery and targeting for the treatment of pancreatic cancer

Nilkamal Pramanik,

Aditya Gupta,

Yashwardhan Ghanwatkar

et al.

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Cited by 7 publications

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Beyond Lipids: Exploring Advances in Polymeric Gene Delivery in the Lipid Nanoparticles Era

Jogdeo,

Siddhanta,

Das

et al. 2024

Advanced Materials

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The recent success of gene therapy during the COVID‐19 pandemic has underscored the importance of effective and safe delivery systems. Complementing lipid‐based delivery systems, polymers present a promising alternative for gene delivery. Significant advances have been made in the recent past, with multiple clinical trials progressing beyond phase I and several companies actively working on polymeric delivery systems which provides assurance that polymeric carriers can soon achieve clinical translation. The massive advantage of structural tunability and vast chemical space of polymers is being actively leveraged to mitigate shortcomings of traditional polycationic polymers and improve the translatability of delivery systems. Tailored polymeric approaches for diverse nucleic acids and for specific subcellular targets are now being designed to improve therapeutic efficacy. This review describes the recent advances in polymer design for improved gene delivery by polyplexes and covalent polymer‐nucleic acid conjugates. The review also offers a brief note on novel computational techniques for improved polymer design. We conclude with an overview of the current state of polymeric gene therapies in the clinic as well as future directions on their translation to the clinic.This article is protected by copyright. All rights reserved

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Beyond Lipids: Exploring Advances in Polymeric Gene Delivery in the Lipid Nanoparticles Era

Jogdeo,

Siddhanta,

Das

et al. 2024

Advanced Materials

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Neutrophil-targeted liposomal platform: A shift in novel approach for early detection and treatment of cancer metastasis

Li,

Zhang,

Cheng

et al. 2024

Asian Journal of Pharmaceutical Sciences

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Recent advances in reactive oxygen species (ROS)-responsive drug delivery systems for photodynamic therapy of cancer

Hu,

Li,

et al. 2024

Acta Pharmaceutica Sinica B

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Recent advances in drug delivery and targeting for the treatment of pancreatic cancer

Cited by 7 publications

References 207 publications

Beyond Lipids: Exploring Advances in Polymeric Gene Delivery in the Lipid Nanoparticles Era

Beyond Lipids: Exploring Advances in Polymeric Gene Delivery in the Lipid Nanoparticles Era

Neutrophil-targeted liposomal platform: A shift in novel approach for early detection and treatment of cancer metastasis

Recent advances in reactive oxygen species (ROS)-responsive drug delivery systems for photodynamic therapy of cancer

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