Recent advances in electrochemical transduction of chiral information

Wireless electrochemical actuation of soft materials towards chiral stimuli

“…16,17 For example, recently the wireless concept of bipolar electrochemistry was coupled with chirality to develop new unconventional electrochemical systems that are able to transfer the chiral stimuli from the molecular level to the macroscopic scale through 2D and 3D dynamic approaches. 18 In this Feature Article, at first, the basic concepts of electromechanical actuation of pconjugated polymers are presented, followed by a description of the bipolar electrochemistry approach and its possible use to trigger actuation. Afterwards the outstanding synergy between wireless electrochemistry and chiral recognition is illustrated.…”

“…cyclodextrins, metal–organic frameworks or molecular imprinted modified electrodes, such outstanding detection is not possible since in such approaches the differentiation between enantiomers of chiral analytes is in terms of current intensity, without differences in thermodynamic potential values. 18,56,58–78…”

Magnetic field-enhanced redox chemistry on-the-fly for enantioselective synthesis

“…[14][15][16] In particular the latter approach presents outstanding enantioselectivity, related to diastereomeric interactions between the chiral oligomer surface and the analyte antipodes in solution, resulting in thermodynamic differences in terms of redox potentials, which allow the preferential conversion of only one of the analyte enantiomers. 17,18 This energetic differentiation has been exploited to design unconventional approaches for the electrochemical recognition of chiral probes. [19][20][21] Furthermore, these oligomeric systems were used for the enantioselective conversion of molecules with a prostereogenic carbon-oxygen double bond into the corresponding chiral hydroxyl derivatives via chemistry-onthe-y.…”

Wireless electromechanical enantio‐responsive valves

“…Such electrochemically driven actuation is based on an asymmetric uptake/release of ions inside the polymer matrix, which causes a swelling/shrinking process 30,31 . Recently, such wireless actuation has been successfully used as a powerful tool for the transduction of chiral information based on an electromechanical readout 32–34 . The approach is based on the coupling of the reduction of polypyrrole (Ppy) (Scheme 1A) with the enantioselective oxidation of a chiral probe on the surface of an inherently chiral oligomer.…”

“…30,31 Recently, such wireless actuation has been successfully used as a powerful tool for the transduction of chiral information based on an electromechanical readout. [32][33][34] The approach is based on the coupling of the reduction of polypyrrole (Ppy) (Scheme 1A) with the enantioselective oxidation of a chiral probe on the surface of an inherently chiral oligomer. Due to the energetically different interactions between the chiral oligomer surface and the probe in solution, enantiodiscrimination in terms of difference in oxidation potentials can be achieved.…”