Recent Advances in Electrochemiluminescence Sensors for Pathogenic Bacteria Detection

Shen, Jinjin; Zhou, Ting; Huang, Ru

doi:10.3390/mi10080532

Cited by 43 publications

(15 citation statements)

References 116 publications

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“…Moreover, they have been acutely employed for sensing numerous proteins, nucleic acids and metal ions. With reference to the fluorescence methods, ECL does not need an excitation light source, thus it avoids a scattered light background or auto-fluorescence [185,187,188]. Applied electric potential induces and controls the output signal for assuring the accuracy as well as the reproducibility of ECL.…”

Section: Electrochemiluminescence-based Gqd-sensorsmentioning

confidence: 99%

Applications of Graphene Quantum Dots in Biomedical Sensors

Mansuriya

Altıntaş

2020

Sensors

190

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Due to the proliferative cancer rates, cardiovascular diseases, neurodegenerative disorders, autoimmune diseases and a plethora of infections across the globe, it is essential to introduce strategies that can rapidly and specifically detect the ultralow concentrations of relevant biomarkers, pathogens, toxins and pharmaceuticals in biological matrices. Considering these pathophysiologies, various research works have become necessary to fabricate biosensors for their early diagnosis and treatment, using nanomaterials like quantum dots (QDs). These nanomaterials effectively ameliorate the sensor performance with respect to their reproducibility, selectivity as well as sensitivity. In particular, graphene quantum dots (GQDs), which are ideally graphene fragments of nanometer size, constitute discrete features such as acting as attractive fluorophores and excellent electro-catalysts owing to their photo-stability, water-solubility, biocompatibility, non-toxicity and lucrativeness that make them favorable candidates for a wide range of novel biomedical applications. Herein, we reviewed about 300 biomedical studies reported over the last five years which entail the state of art as well as some pioneering ideas with respect to the prominent role of GQDs, especially in the development of optical, electrochemical and photoelectrochemical biosensors. Additionally, we outline the ideal properties of GQDs, their eclectic methods of synthesis, and the general principle behind several biosensing techniques.

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Section: Electrochemiluminescence-based Gqd-sensorsmentioning

confidence: 99%

Applications of Graphene Quantum Dots in Biomedical Sensors

Mansuriya

Altıntaş

2020

Sensors

190

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“…Recently, excellent reviews regarding ECL have been published, including a minireview on the ECL single-cell analysis that has emerged in recent years [9] and a review on pathogenic bacteria detection [10]. In contrast, in this present review, recent studies ranging from single-cell systems to cell aggregates and cell secretions, focusing on mammalian cells, are reviewed to give a comprehensive summary.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Electrochemiluminescence-Based Systems for Mammalian Cell Analysis

et al. 2020

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Mammalian cell analysis is essential in the context of both fundamental studies and clinical applications. Among the various techniques available for cell analysis, electrochemiluminescence (ECL) has attracted significant attention due to its integration of both electrochemical and spectroscopic methods. In this review, we summarize recent advances in the ECL-based systems developed for mammalian cell analysis. The review begins with a summary of the developments in luminophores that opened the door to ECL applications for biological samples. Secondly, ECL-based imaging systems are introduced as an emerging technique to visualize single-cell morphologies and intracellular molecules. In the subsequent section, the ECL sensors developed in the past decade are summarized, the use of which made the highly sensitive detection of cell-derived molecules possible. Although ECL immunoassays are well developed in terms of commercial use, the sensing of biomolecules at a single-cell level remains a challenge. Emphasis is therefore placed on ECL sensors that directly detect cellular molecules from small portions of cells or even single cells. Finally, the development of bipolar electrode devices for ECL cell assays is introduced. To conclude, the direction of research in this field and its application prospects are described.

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“…Hence, the efficiency of ECL biosensors will be increased due to the use of different nanomaterials, such as graphene, carbon dots, quantum dots, metal nanoclusters, etc. combined with the recognition element and electrode modification strategy more appropriate [ 43 ].…”

Section: Introductionmentioning

confidence: 99%

Electrochemiluminescence Biosensors Using Screen-Printed Electrodes

et al. 2020

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Electrogenerated chemiluminescence (also called electrochemiluminescence (ECL)) has become a great focus of attention in different fields of analysis, mainly as a consequence of the potential remarkably high sensitivity and wide dynamic range. In the particular case of sensing applications, ECL biosensor unites the benefits of the high selectivity of biological recognition elements and the high sensitivity of ECL analysis methods. Hence, it is a powerful analytical device for sensitive detection of different analytes of interest in medical prognosis and diagnosis, food control and environment. These wide range of applications are increased by the introduction of screen-printed electrodes (SPEs). Disposable SPE-based biosensors cover the need to perform in-situ measurements with portable devices quickly and accurately. In this review, we sum up the latest biosensing applications and current progress on ECL bioanalysis combined with disposable SPEs in the field of bio affinity ECL sensors including immunosensors, DNA analysis and catalytic ECL sensors. Furthermore, the integration of nanomaterials with particular physical and chemical properties in the ECL biosensing systems has improved tremendously their sensitivity and overall performance, being one of the most appropriates research fields for the development of highly sensitive ECL biosensor devices.

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Recent Advances in Electrochemiluminescence Sensors for Pathogenic Bacteria Detection

Cited by 43 publications

References 116 publications

Applications of Graphene Quantum Dots in Biomedical Sensors

Applications of Graphene Quantum Dots in Biomedical Sensors

Recent Advances in Electrochemiluminescence-Based Systems for Mammalian Cell Analysis

Electrochemiluminescence Biosensors Using Screen-Printed Electrodes

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