Recent advances in electrospun nanofibers for some biomedical applications

Sabra, Sally; Ragab, Doaa; Agwa, Mona M.; Rohani, Sohrab

doi:10.1016/j.ejps.2020.105224

Cited by 96 publications

(51 citation statements)

References 163 publications

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“…A major challenge in the field of treatment of wounds with various etiologies, which is based on electrospun nanofibers mats, is the transfer from laboratory research to clinical research [ 81 ]. In order to make this transfer, the scientist’s attention must be directed to overcome some limitations of the current wound dressing formulation such as generation of cell seeded multilayered patches and fine-tuning degradation.…”

Section: Electrospun Nanofibers In Wound Healingmentioning

confidence: 99%

An Overview of Biopolymeric Electrospun Nanofibers Based on Polysaccharides for Wound Healing Management

et al. 2020

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Currently, despite the thoroughgoing scientific research carried out in the area of wound healing management, the treatment of skin injuries, regardless of etiology remains a big provocation for health care professionals. An optimal wound dressing should be nontoxic, non-adherent, non-allergenic, should also maintain a humid medium at the wound interfacing, and be easily removed without trauma. For the development of functional and bioactive dressings, they must meet different conditions such as: The ability to remove excess exudates, to allow gaseous interchange, to behave as a barrier to microbes and to external physical or chemical aggressions, and at the same time to have the capacity of promoting the process of healing by stimulating other intricate processes such as differentiation, cell adhesion, and proliferation. Over the past several years, various types of wound dressings including hydrogels, hydrocolloids, films, foams, sponges, and micro/nanofibers have been formulated, and among them, the electrospun nanofibrous mats received an increased interest from researchers due to the numerous advantages and their intrinsic properties. The drug-embedded nanofibers are the potential candidates for wound dressing application by virtue of: Superior surface area-to volume ratio, enormous porosity (can allow oxy-permeability) or reticular nano-porosity (can inhibit the microorganisms’adhesion), structural similitude to the skin extracellular matrix, and progressive electrospinning methodology, which promotes a prolonged drug release. The reason that we chose to review the formulation of electrospun nanofibers based on polysaccharides as dressings useful in wound healing was based on the ever-growing research in this field, research that highlighted many advantages of the nanofibrillary network, but also a marked versatility in terms of numerous active substances that can be incorporated for rapid and infection-free tissue regeneration. In this review, we have extensively discussed the recent advancements performed on electrospun nanofibers (eNFs) formulation methodology as wound dressings, and we focused as well on the entrapment of different active biomolecules that have been incorporated on polysaccharides-based nanofibers, highlighting those bioagents capable of improving the healing process. In addition, in vivo tests performed to support their increased efficacy were also listed, and the advantages of the polysaccharide nanofiber-based wound dressings compared to the traditional ones were emphasized.

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Section: Electrospun Nanofibers In Wound Healingmentioning

confidence: 99%

An Overview of Biopolymeric Electrospun Nanofibers Based on Polysaccharides for Wound Healing Management

et al. 2020

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“…Electrospun nanober membranes can be used to encapsulated biomolecules and have broad prospects for drug delivery applications. 6,10 Drugs can be embedded into nanober membranes in amorphous or nanocrystalline form to produce exible sheets very similar to the extracellular membrane for drug loading, 2 with high drug loading capacity and high encapsulation efficiency. 4 At the same time, the porous structure of nanobers can creat a suitable moist environment for the wound, which is conducive to wound healing.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of green poly(vinyl alcohol) nanofibers using natural deep eutectic solvent for fast-dissolving drug delivery

et al. 2021

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“…In particular, many nanodevices (i.e., nanofibers and nanoparticles) have been developed to serve as antimicrobial agents to avoid pathogens' proliferation. In literature, a large number of articles can be found, describing the transport of antimicrobial agents, mainly, but not only, to the skin compartment in the wound treatment, in order to prevent infections and/or to accelerate the healing process [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Nanotechnologies: An Innovative Tool to Release Natural Extracts with Antimicrobial Properties

et al. 2021

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Site-Specific release of active molecules with antimicrobial activity spurred the interest in the development of innovative polymeric nanocarriers. In the preparation of polymeric devices, nanotechnologies usually overcome the inconvenience frequently related to other synthetic strategies. High performing nanocarriers were synthesized using a wide range of starting polymer structures, with tailored features and great chemical versatility. Over the last decade, many antimicrobial substances originating from plants, herbs, and agro-food waste by-products were deeply investigated, significantly catching the interest of the scientific community. In this review, the most innovative strategies to synthesize nanodevices able to release antimicrobial natural extracts were discussed. In this regard, the properties and structure of the starting polymers, either synthetic or natural, as well as the antimicrobial activity of the biomolecules were deeply investigated, outlining the right combination able to inhibit pathogens in specific biological compartments.

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Recent advances in electrospun nanofibers for some biomedical applications

Cited by 96 publications

References 163 publications

An Overview of Biopolymeric Electrospun Nanofibers Based on Polysaccharides for Wound Healing Management

An Overview of Biopolymeric Electrospun Nanofibers Based on Polysaccharides for Wound Healing Management

Fabrication of green poly(vinyl alcohol) nanofibers using natural deep eutectic solvent for fast-dissolving drug delivery

Nanotechnologies: An Innovative Tool to Release Natural Extracts with Antimicrobial Properties

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