Recent advances in enterovirus A71 pathogenesis: a focus on fatal human enterovirus A71 infection

Xing, Jiali; Wang, Ke; Wang, Geng; Li, Na; Zhang, Yanru

doi:10.1007/s00705-022-05606-4

Cited by 10 publications

(6 citation statements)

References 131 publications

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“…Additionally, strong CEV antigen signals were also detected in the lung and intestines, which is congruent with the clinical signs characterized by digestive and respiratory disorders observed in goats with CEV infections. It is worthwhile to mention that strong CEV antigen signals were revealed in the liver, which was different to the available reports on enterovirus infection [ 2 , 25 ]. Whether CEV-JL14 strain has a specific tissue tropism to liver, or it is a general pattern for different CEV strains is an interesting subject for future investigation.…”

Section: Discussioncontrasting

confidence: 94%

A Neonatal Murine Model for Caprine Enterovirus Infection and the Viral Tissue Tropism

Zhang

Chang

et al. 2023

Viruses

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As the first caprine enterovirus identified from goat herds characterized by severe diarrhea with a high morbidity and mortality rate, the underlying pathogenesis and tissue tropism for CEV-JL14 remains largely unknown. Here, we reported the establishment of a neonatal murine model for caprine enterovirus and the unveiling of the tissue tropism and underlying pathogenesis for CEV-JL14 enterovirus. Susceptible murine strains, the infective dose, the infective routes, viral loads, and tissue tropism for CEV-JL14 infection were determined. The findings showed that ICR mice were susceptible to CEV-JL14 infection via all infection routes. Tissue viral load analysis showed that CEV-JL14 was detected in almost all tissues including the heart, liver, spleen, lung, kidney, intestine, brain, and muscle, with significantly higher viral loads in the heart, liver, lung, kidney, and intestine. These results revealed the pattern of viral load and tropism for CEV-JL14 and provided a model system for elucidating the pathogenesis of CEV-JL14 viruses.

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Section: Discussioncontrasting

confidence: 94%

A Neonatal Murine Model for Caprine Enterovirus Infection and the Viral Tissue Tropism

Zhang

Chang

et al. 2023

Viruses

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“…Its open reading frame can be translated into 11 functional viral proteins, including 4 structure proteins (VP1, VP2, VP3, and VP4) and 7 non-structure proteins (2A, 2B, 2C, 3A, 3B, 3C, and 3D) [ 6 ]. After EV-A71 infects the host, it first invades gastrointestinal cells and utilizes them as the primary replication site [ 7 ]. Infection is initiated when the virus binds to a specific receptor on the cell surface, such as scavenger receptor class B, member 2, and then enters the cytoplasm of the target cell using receptor-mediated endocytosis [ 2 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Cordycepin Inhibits Enterovirus A71 Replication and Protects Host Cell from Virus-Induced Cytotoxicity through Adenosine Action Pathway

Lee,

Yu,

Wong

et al. 2024

Viruses

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Enterovirus A71 (EV-A71) infection typically causes mild illnesses, such as hand-foot-and-mouth disease (HFMD), but occasionally leads to severe or fatal neurological complications in infants and young children. Currently, there is no specific antiviral treatment available for EV-A71 infection. Thus, the development of an effective anti-EV-A71 drug is required urgently. Cordycepin, a major bioactive compound found in Cordyceps fungus, has been reported to possess antiviral activity. However, its specific activity against EV-A71 is unknown. In this study, the potency and role of cordycepin treatment on EV-A71 infection were investigated. Results demonstrated that cordycepin treatment significantly reduced the viral load and viral ribonucleic acid (RNA) level in EV-A71-infected Vero cells. In addition, EV-A71-mediated cytotoxicity was significantly inhibited in the presence of cordycepin in a dose-dependent manner. The protective effect can also be extended to Caco-2 intestinal cells, as evidenced by the higher median tissue culture infectious dose (TCID50) values in the cordycepin-treated groups. Furthermore, cordycepin inhibited EV-A71 replication by acting on the adenosine pathway at the post-infection stage. Taken together, our findings reveal that cordycepin could be a potential antiviral candidate for the treatment of EV-A71 infection.

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“…Since 2008, HFMD has been classified as a Class C infectious disease in China. [ 1 ] Although most cases of HFMD are mild and self-limiting, some children may develop severe complications. Usually, HFMD has an incubation period of 2 to 10 days, and its symptoms include fever and rash on the hands, feet, mouth, and buttocks.…”

Section: Introductionmentioning

confidence: 99%

Frontiers and hotspots in hand, foot, and mouth disease research during 2006 to 2023: A bibliometric and visual analysis

Li,

Ruan,

Zhai

et al. 2024

Medicine

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Background: Enteroviruses-infected hand, foot, and mouth disease (HFMD) seriously threatens human health. This study aimed to analyze the research status, hotspots, and frontiers of HFMD. Methods: Publications on HFMD between January 1, 2006, and January 31, 2023, were retrieved from the Web of Science Core database. Bibliometric tools, including CiteSpace, VOSviewer, R package “Bibiometrix,” SCImago Graphica, and Charticulator, were utilized to analyze and visualize the data. Results: A total of 1860 articles from 424 journals, involving 8815 authors from 64 countries and 1797 institutions were analyzed. The number of studies on HFMD has shown an increasing trend over the past 18 years, with an annual increase observed since 2006, which is particularly prominent after 2010. Research in this field has centered on the Asian region. Notably, the research hotspots were mainly focused on vaccines, epidemiology, and pathogenesis of HFMD. Among the researchers in this field, Zhang Yong emerged as the most prolific author, while Xu Wenbo had the most significant influence. The Chinese Academy of Sciences was the most productive institution, and China was the most productive country for HFMD research. Conclusion: By bibliometric analysis, researchers in the HMFD field can efficiently identify and visually represent their research focus and limitations. In the future, it is crucial to maintain ongoing surveillance of HFMD outbreaks and their pathogenic changes. Additionally, future research should extensively explore the molecular mechanisms underlying Enteroviruses-induced HFMD with a focus on developing vaccines and therapies.

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Recent advances in enterovirus A71 pathogenesis: a focus on fatal human enterovirus A71 infection

Cited by 10 publications

References 131 publications

A Neonatal Murine Model for Caprine Enterovirus Infection and the Viral Tissue Tropism

A Neonatal Murine Model for Caprine Enterovirus Infection and the Viral Tissue Tropism

Cordycepin Inhibits Enterovirus A71 Replication and Protects Host Cell from Virus-Induced Cytotoxicity through Adenosine Action Pathway

Frontiers and hotspots in hand, foot, and mouth disease research during 2006 to 2023: A bibliometric and visual analysis

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