Conventional
fluorophores suffer from low sensitivity and selectivity
in amine detection due to the inherent limitations in their “one-to-one”
stoichiometric sensing mechanism. Herein, we propose a “one-to-many”
chain reaction-like sensing mechanism by creating a domino chain consisting
of one fluorescent molecule (e.g., PTF1) and up to 40 nonemissive
polymer chains (pPFPA) comprising over thousand repeating units (PFPA).
PTF1 (the domino trigger) interacts with adjacent PFPA units (the
following blocks) through polar−π interactions and initiates
the domino effect, creating effective through-space conjugation along
pPFPA chains and generating amplified yellow fluorescent signals through
charge transfer between PTF1 and pPFPA. Amine exposure causes rapid
dismantling of the fluorophore-pPFPA-based domino chain and significantly
reduces the amplified emissions, thus providing an ultrasensitive
method for detecting amines. Relying on the above merits, we achieve
a limit of detection of 177 ppq (or 1.67 × 10–12 M) for triethylamine, which is nearly 4 orders lower than that of
previous methods. Additionally, the distinct reactivity of pPFPA toward
different amines allows for the discrimination of primary, secondary,
and tertiary amines. This study presents a “domino effect”
sensing mechanism that has not yet been reported and provides a general
approach for chemical detection that is beyond the reach of conventional
methods.