Recent advances in Fragment-based strategies against tuberculosis

Villemagne, Baptiste; Faïon, Léo; Tangara, Salia; Willand, Nicolas

doi:10.1016/j.ejmech.2023.115569

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2025

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Cited by 4 publications

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“…Introduction of dominant structural units/fragments with good drug-like and proprietary properties into the molecular backbone of a drug can greatly improve its biological activity. 10 FBDD has been used to develop some drugs on the market ( e.g. , pexidartinib, vemurafenib, and erdafitinib) as well as several drugs in the clinical pipeline.…”

Section: Introductionmentioning

confidence: 99%

New azole derivatives linked to indole/indoline moieties combined with FLC against drug-resistant Candida albicans

Shen,

Pan,

Gao

et al. 2024

RSC Med. Chem.

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Section: Introductionmentioning

confidence: 99%

New azole derivatives linked to indole/indoline moieties combined with FLC against drug-resistant Candida albicans

Shen,

Pan,

Gao

et al. 2024

RSC Med. Chem.

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Synthesis and antifungal evaluation of new azole derivatives containing 1,2,3-triazole

Huang,

Chen,

Zhang

et al. 2025

RSC Med. Chem.

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Perspectives on Applications of 19F-NMR in Fragment-Based Drug Discovery

Li,

Kang

2024

Molecules

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Fragment-based drug discovery is a powerful approach in drug discovery, applicable to a wide range of targets. This method enables the discovery of potent compounds that can modulate target functions, starting from fragment compounds that bind weakly to the targets. While biochemical, biophysical, and cell-based assays are commonly used to identify fragments, 19F-NMR spectroscopy has emerged as a powerful tool for exploring interactions between biomolecules and ligands. Because fluorine atoms are not naturally present in biological systems, 19F-NMR serves as a sensitive method for fragment screening against diverse targets. Herein, we reviewed the applications of 19F-NMR in fragment screening, highlighting its effectiveness in identifying fragments that bind weakly to various targets such as proteins and RNA. The accumulated evidence suggests that 19F-NMR will continue to be a crucial tool in drug discovery.

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Recent advances in Fragment-based strategies against tuberculosis

Cited by 4 publications

References 71 publications

New azole derivatives linked to indole/indoline moieties combined with FLC against drug-resistant Candida albicans

New azole derivatives linked to indole/indoline moieties combined with FLC against drug-resistant Candida albicans

Synthesis and antifungal evaluation of new azole derivatives containing 1,2,3-triazole

Perspectives on Applications of 19F-NMR in Fragment-Based Drug Discovery

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