Recent advances in functional nanomaterials for light–triggered cancer therapy

Gai, Shili; Yang, Guixin; Yang, Piaoping; He, Fei; Lin, Jun; Jin, Dayong; Xing, Bengang

doi:10.1016/j.nantod.2018.02.010

Cited by 498 publications

(292 citation statements)

References 496 publications

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“…The toxic side effects of nanomedicine in vivo are a major issue in cancer therapy . In this study, the in vivo biosafety of MON@PCBMA was determined based on blood biochemistry and routine blood tests.…”

Section: Resultsmentioning

confidence: 99%

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Zwitterionic Polymer Coating of Sulfur Dioxide‐Releasing Nanosystem Augments Tumor Accumulation and Treatment Efficacy

Yao

Peng

et al. 2020

Adv Healthcare Materials

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Multiple drug resistance (MDR) exhibited by cancer cells and low intratumor accumulation of chemotherapeutics are the main obstacles in cancer chemotherapy. Herein, the preparation of a redox‐responsive sulfur dioxide (SO2)‐releasing nanosystem, with high SO2‐loading capacity, aimed at improving the treatment efficacy of cancers exhibiting MDR is described. The multifunctional nanomedicine (MON‐DN@PCBMA‐DOX) is designed and constructed by coating mesoporous organosilica nanoparticles with a zwitterionic polymer, poly(carboxybetaine methacrylate) (PCBMA), which can concurrently load SO2 prodrug molecules (DN, 2,4‐dinitrobenzenesulfonylchloride) and chemotherapeutics (DOX, doxorubicin). The generated SO2 molecules can sensitize cells to chemotherapy and overcome the MDR by downregulating the expression of P‐glycoprotein. Furthermore, the PCBMA coating prolongs the blood circulation time of the inner core, leading to an increased intratumor accumulation of the nanomedicine. Owing to the prolonged blood circulation, enhanced tumor accumulation, and SO2 sensitization of cells to chemotherapy, the nanomedicine exhibits excellent tumor suppression with a tumor inhibition rate of 94.8%, and might provide a new platform for cancer therapy.

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Section: Resultsmentioning

confidence: 99%

“…The cytotoxicity of MON@PCBMA, free DOX, MON‐DN@PCBMA, and MON‐DN@PCBMA‐DOX was measured as previously described . First, MCF‐7 and MCF‐7/ADR cells were seeded into a 96‐well plate.…”

Section: Methodsmentioning

confidence: 99%

Zwitterionic Polymer Coating of Sulfur Dioxide‐Releasing Nanosystem Augments Tumor Accumulation and Treatment Efficacy

Yao

Peng

et al. 2020

Adv Healthcare Materials

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“…Materials: Analytical grade ammonium fluoride (NH 4 (x mmol), and ErCl 3 (0.02 mmol)] was added to a 100 mL three-necked flask containing OA (8 mL) and ODE (12 mL). Then, the mixture was heated to 150 °C for 1 h with vigorous stirring to remove deionized water.…”

Section: Methodsmentioning

confidence: 99%

“…[1][2][3][4][5] In particular, the application on single-molecule probe and high-resolution display have been under extensive attention recently. [1][2][3][4][5] In particular, the application on single-molecule probe and high-resolution display have been under extensive attention recently.…”

Section: Introductionmentioning

confidence: 99%

Atomic‐Level Passivation of Individual Upconversion Nanocrystal for Single Particle Microscopic Imaging

Min

Jing

Guo

et al. 2019

Adv Funct Materials

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Lanthanide-doped upconversion nanoparticles (UCNPs) have significant applications for single-molecule probes and high-resolution display. However, one of their major hurdles is the weak luminescence, and this remains a grand challenge to achieve at the single-particle level. Here, 484-fold luminescence enhancement in LuF 3 :Yb 3+ , Er 3+ rhombic flake UCNPs is achieved, thanks to the Yb 3+ -mediated local photothermal effect, and their original morphology, size, and good dispersibility are well preserved. These data show that the surface atomic structure of UCNPs as well as transfer from amorphous to ordered crystal structure is modulated by making use of the local photothermal conversion that is generated by the directional absorption of 980 nm light by Yb 3+ ions. The confocal luminescence images obtained by superresolution stimulated emission depletion also show the great enhancement of individual LuF 3 :Yb 3+ , Er 3+ nanoparticles; the high signal-to-noise ratio images indicate that the laser treatment technology opens the door for single particle imaging and practical application.The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/adfm.201906137. studies obtained in the last decades are performed by a cluster of nanoparticles, which is quite different from that of an individual particle. [9,10] Research by Haro-González and co-workers demonstrates that the total fluorescence intensity of nanoparticle group not only depends on the number of particles, but also on the direction of the excitation polarization and the orientation of the UCNPs. [11] Unfortunately, a major obstacle for practical application of UCNPs at single particle level is still their weak luminescence. [12][13][14] Thus, it is necessary to find a useful strategy to optimize the optical properties of individual up-conversion nanoparticle (UCNP) for better luminescence efficiency.Complicated surface states of UCNPs play an important role in their upconversion efficiency, in which majority atoms combine with the enriched surface defects, leading a serious surface quenching effect. [15][16][17] To date, many surface passivation strategies, [18] like annealing treatment [17,19] and coating technology, [20,21] have been proposed for improving upconversion luminescence (UCL), however most of these efforts may not necessarily lead to the optimal enhancement at the single-particle level. This is because 1) annealing treatment can cause agglomeration of UCNPs and 2) the use of coreshell configuration is difficult to achieve in 1D and 2D core UCNPs. Thus, it is urgent to find a useful strategy that can not only efficiently passivate surface defects, but also maintain the good uniformity of particle size, morphology, and the excellent dispersibility.In this work, Yb 3+ -/Er 3+ -codoped LuF 3 UCNPs were synthesized by co-precipitation method, and irradiated by high-energy near-infrared (NIR) laser ( Figure S2, Supporting Information). Here, we propose photothermal conversion in the local lattice ...

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“…Light source is an essential element for both PA imaging and PTT. Current PA imaging and PTT are mainly conducted utilizing the near‐infrared (NIR) light ranging from 750 to 1000 nm, which is defined as the first NIR window (NIR‐I) with a relatively low interaction with tissues . However, the tissue penetration depth of NIR‐I light is only around 1 cm, which cannot fulfill the requirement of the translational study of PA imaging and PTT.…”

Section: Introductionmentioning

confidence: 99%

Second Near‐Infrared Absorbing Agents for Photoacoustic Imaging and Photothermal Therapy

2019

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Photoacoustic (PA) imaging and photothermal therapy (PTT) provide useful tools for diagnosis and treatments of diseases. However, current applications of PA imaging and PTT are greatly limited by their relying on light source in the first near‐infrared (NIR) window (NIR‐I, 750–1000 nm), which shows shallow tissue penetration depth. Recently, this predicament is addressed by the use of second NIR (NIR‐II) light ranging from 1000 to 1700 nm due to reduced light–tissue interaction and increased allowable power density for light irradiation. Since a few endogenous biomolecules can absorb or emit NIR‐II light, it is necessary to develop contrast and therapeutic agents used for PA imaging and PTT in the NIR‐II window. This review summarizes the recent progresses of NIR‐II absorbing optical agents for PA imaging and PTT in living animal models. The prominent performance of NIR‐II PA imaging and NIR‐II PTT is first introduced with the use of optical agents, followed by discussion of the applications of NIR‐II PTT under the guidance of NIR‐I or NIR‐II PA imaging. At last, challenges and perspectives of NIR‐II absorbing optical agents for PA imaging and PTT are proposed.

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Recent advances in functional nanomaterials for light–triggered cancer therapy

Cited by 498 publications

References 496 publications

Zwitterionic Polymer Coating of Sulfur Dioxide‐Releasing Nanosystem Augments Tumor Accumulation and Treatment Efficacy

Zwitterionic Polymer Coating of Sulfur Dioxide‐Releasing Nanosystem Augments Tumor Accumulation and Treatment Efficacy

Atomic‐Level Passivation of Individual Upconversion Nanocrystal for Single Particle Microscopic Imaging

Second Near‐Infrared Absorbing Agents for Photoacoustic Imaging and Photothermal Therapy

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