Recent advances in GPR35 pharmacology; 5-HIAA serotonin metabolite becomes a ligand

Im, Dong‐Soon

doi:10.1007/s12272-023-01449-y

Cited by 3 publications

(1 citation statement)

References 105 publications

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“…The involvement of GPR35 in inflammation is complex and context-dependent, demonstrating both pro-inflammatory and anti-inflammatory effects in disparate cellular and tissue settings. GPR35 has been implicated in modulating an array of inflammatory responses, including the activation of immune cells, production of cytokines, and chemotactic movements ( 10 – 12 ). It interacts with several signaling pathways, such as MAPK, NF-κB and others, thereby modulating inflammatory signaling dynamics.…”

Section: Introductionmentioning

confidence: 99%

GPR35 acts a dual role and therapeutic target in inflammation

Wu,

Zhang,

Fan

et al. 2023

Front. Immunol.

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GPR35 is a G protein-coupled receptor with notable involvement in modulating inflammatory responses. Although the precise role of GPR35 in inflammation is not yet fully understood, studies have suggested that it may have both pro- and anti-inflammatory effects depending on the specific cellular environment. Some studies have shown that GPR35 activation can stimulate the production of pro-inflammatory cytokines and facilitate the movement of immune cells towards inflammatory tissues or infected areas. Conversely, other investigations have suggested that GPR35 may possess anti-inflammatory properties in the gastrointestinal tract, liver and certain other tissues by curbing the generation of inflammatory mediators and endorsing the differentiation of regulatory T cells. The intricate role of GPR35 in inflammation underscores the requirement for more in-depth research to thoroughly comprehend its functional mechanisms and its potential significance as a therapeutic target for inflammatory diseases. The purpose of this review is to concurrently investigate the pro-inflammatory and anti-inflammatory roles of GPR35, thus illuminating both facets of this complex issue.

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Section: Introductionmentioning

confidence: 99%

GPR35 acts a dual role and therapeutic target in inflammation

Wu,

Zhang,

Fan

et al. 2023

Front. Immunol.

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Disturbances of the gut microbiota-derived tryptophan metabolites as key actors in vagotomy-induced mastitis in mice

He,

Zhao,

et al. 2024

Cell Reports

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The Complex World of Kynurenic Acid: Reflections on Biological Issues and Therapeutic Strategy

Stone,

Darlington,

Badawy

et al. 2024

IJMS

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It has been unequivocally established that kynurenic acid has a number of actions in a variety of cells and tissues, raising, in principle, the possibility of targeting its generation, metabolism or sites of action to manipulate those effects to a beneficial therapeutic end. However, many basic aspects of the biology of kynurenic acid remain unclear, potentially leading to some confusion and misinterpretations of data. They include questions of the source, generation, targets, enzyme expression, endogenous concentrations and sites of action. This essay is intended to raise and discuss many of these aspects as a source of reference for more balanced discussion. Those issues are followed by examples of situations in which modulating and correcting kynurenic acid production or activity could bring significant therapeutic benefit, including neurological and psychiatric conditions, inflammatory diseases and cell protection. More information is required to obtain a clear overall view of the pharmacological environment relevant to kynurenic acid, especially with respect to the active concentrations of kynurenine metabolites in vivo and changed levels in disease. The data and ideas presented here should permit a greater confidence in appreciating the sites of action and interaction of kynurenic acid under different local conditions and pathologies, enhancing our understanding of kynurenic acid itself and the many clinical conditions in which manipulating its pharmacology could be of clinical value.

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Recent advances in GPR35 pharmacology; 5-HIAA serotonin metabolite becomes a ligand

Cited by 3 publications

References 105 publications

GPR35 acts a dual role and therapeutic target in inflammation

GPR35 acts a dual role and therapeutic target in inflammation

Disturbances of the gut microbiota-derived tryptophan metabolites as key actors in vagotomy-induced mastitis in mice

The Complex World of Kynurenic Acid: Reflections on Biological Issues and Therapeutic Strategy

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