Recent Advances in High-Performance Liquid Chromatography of Volatile Natural Products

Barron, Denís; Pabst, Anni

doi:10.1007/978-1-4684-9060-2_2

Cited by 2 publications

(2 citation statements)

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“…Normal-phase HPLC with refractive index detector has also been employed in the analysis of menthol [14]. However, these methods have low sensitivity.…”

Section: Introductionmentioning

confidence: 99%

“…Many methods have been established for the analysis of menthol, including HPLC methods with fluorescence-labeling reagents [ 11 ], refractive index [ 12 ], and polarized photometric detector [ 13 ]. Normal-phase HPLC with refractive index detector has also been employed in the analysis of menthol [ 14 ]. However, these methods have low sensitivity.…”

Section: Introductionmentioning

confidence: 99%

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GC Method Validation for the Analysis of Menthol in Suppository Pharmaceutical Dosage Form

Abualhasan

Zaid

Jaradat

et al. 2017

International Journal of Analytical Chemistry

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Menthol is widely used as a fragrance and flavor in the food and cosmetic industries. It is also used in the medical and pharmaceutical fields for its various biological effects. Gas chromatography (GC) is considered to be a sensitive method for the analysis of menthol. GC chromatographic separation was developed using capillary column (VF-624) and a flame ionization detector (FID). The method was validated as per ICH guidelines for various parameters such as precision, linearity, accuracy, solution stability, robustness, limit of detection, and quantification. The tested validation parameters were found to be within acceptable limits. The method was successfully applied for the quantification of menthol in suppositories formulations. Quality control departments and official pharmacopeias can use our developed method in the analysis of menthol in pharmaceutical dosage formulation and raw material.

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“…Normal-phase HPLC with refractive index detector has also been employed in the analysis of menthol [14]. However, these methods have low sensitivity.…”

Section: Introductionmentioning

confidence: 99%