Recent Advances in Hydrogels and Stem Cells

Nakhlband, Ailar; Saleh-Ghadimi, Laleh; Fathi, Marziyeh; Samiei, Mohammad; Barar, Jaleh; Omidi, Yadollah

doi:10.1007/978-981-16-4420-7_21

Cited by 2 publications

(3 citation statements)

References 147 publications

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“…Immunomodulatory hydrogels and gels, which are specifically created to maximize cell survival and integration at the transplantation site, have the potential to greatly improve the effectiveness of stem cell transplantation for severe disorders. [126,127] Peptide-selfassembled hydrogels are highly sought-after biomaterials in biomedicine due to their ability to create three-dimensional scaffolds that support the growth and multiplication of neurons. These hydrogels are particularly valuable in the treatment of brain disorders.…”

Section: Hydrogels: Applications In Cnsmentioning

confidence: 99%

“…Injectable hydrogel materials used as carriers for stem cell transport may effectively address many difficulties, including poor cell survival, limited differentiation, stimulation of host immunological response, and production of teratomas. Immunomodulatory hydrogels and gels, which are specifically created to maximize cell survival and integration at the transplantation site, have the potential to greatly improve the effectiveness of stem cell transplantation for severe disorders [126,127] . Peptide‐self‐assembled hydrogels are highly sought‐after biomaterials in biomedicine due to their ability to create three‐dimensional scaffolds that support the growth and multiplication of neurons.…”

Section: Limitations Imposed By Biology On the Transportation Of Drug...mentioning

confidence: 99%

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Hydrogel nanoparticles as new drug delivery system for CNS disorders

Omar Khudhur,

Karimian,

Asadi

et al. 2024

ChemistrySelect

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Previous studies have shown that more than one million individuals suffer from central nervous system (CNS) diseases worldwide. Nanogels are a good way to deliver drugs because they are ultra‐stable, can hold a lot of drugs, have a core‐shell structure, are very permeable, and can get into brain tissue both in the lab and in living organisms. The blood‐brain barrier (BBB) and the blood‐cerebrospinal fluid barrier (BCSFB) make it harder to deliver therapies to specific areas of the CNS because drugs can′t get into the brain well enough. However, these barriers help treat neurological disorders like epilepsy, neurodegenerative diseases, brain tumors, and ischemic stroke. A number of biological studies suggest that nano‐additives may improve the shape, mechanical properties, electrical conductivity, and biological activities of hydrogels. The creation of nanogels for CNS drug delivery, their early preclinical success, and their potential for neurotoxicity are all examined in this research. This study looks at techniques that are almost ready for clinical use, a preclinical delivery system for the CNS, and the use of nanogels as a successful BBB‐penetration method. It also examines the main difficulties that nanogels must overcome in order to provide the most effective therapeutic care for CNS illnesses.

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Section: Hydrogels: Applications In Cnsmentioning

confidence: 99%

Section: Limitations Imposed By Biology On the Transportation Of Drug...mentioning

confidence: 99%

Hydrogel nanoparticles as new drug delivery system for CNS disorders

Omar Khudhur,

Karimian,

Asadi

et al. 2024

ChemistrySelect

View full text Add to dashboard Cite

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“…Previous efforts have designed hydrogels with controlled degradation properties for cell encapsulation and delivery into the injured tendon tissues ( Qiu et al, 2011 ). Recent studies have also reported that functionally-adapted hydrogels with tunable structures and properties provide favorable substrates for the proliferation and tenogenic differentiation of seeded stem cells ( Zhang et al, 2021a ; Nakhlband et al, 2021 ; Xu et al, 2022a ). Therefore, in addition to serving as delivery vehicles, the role of hydrogels in regulating stem cell fate has raised the enthusiasm of researchers to design novel hydrogels.…”

Section: Applications Of Hydrogel/stem Cell Therapy In Tendon Repairmentioning

confidence: 99%

Applications of functionally-adapted hydrogels in tendon repair

Liu

Fan

2023

Front. Bioeng. Biotechnol.

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Despite all the efforts made in tissue engineering for tendon repair, the management of tendon injuries still poses a challenge, as current treatments are unable to restore the function of tendons following injuries. Hydrogels, due to their exceptional biocompatibility and plasticity, have been extensively applied and regarded as promising candidate biomaterials in tissue regeneration. Varieties of approaches have designed functionally-adapted hydrogels and combined hydrogels with other factors (e.g., bioactive molecules or drugs) or materials for the enhancement of tendon repair. This review first summarized the current state of knowledge on the mechanisms underlying the process of tendon healing. Afterward, we discussed novel strategies in fabricating hydrogels to overcome the issues frequently encountered during the applications in tendon repair, including poor mechanical properties and undesirable degradation. In addition, we comprehensively summarized the rational design of hydrogels for promoting stem-cell-based tendon tissue engineering via altering biophysical and biochemical factors. Finally, the role of macrophages in tendon repair and how they respond to immunomodulatory hydrogels were highlighted.

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Recent Advances in Hydrogels and Stem Cells

Cited by 2 publications

References 147 publications

Hydrogel nanoparticles as new drug delivery system for CNS disorders

Hydrogel nanoparticles as new drug delivery system for CNS disorders

Applications of functionally-adapted hydrogels in tendon repair

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