Recent advances in hydrogels for preventing tumor recurrence

Qian, Qiuhui; Song, Jie; Chen, Chen; Pu, Qian; Liu, Xingcheng; Wang, Huili

doi:10.1039/d3bm00003f

Cited by 8 publications

(5 citation statements)

References 191 publications

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“…Moreover, hydrogel wound dressing has good deformability and is helpful for wound repair [ 75 ]. Due to the ability to cover the postoperative site and maintain the continuous release of drugs, hydrogels even have great potential in preventing tumor recurrence [ 76 ]. Through the engineering design of hydrogels, precise control of RNA therapy can be achieved from the hydrogel loading and controlled release of RNA [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

Chitosan Hydrogel-Delivered ABE8e Corrects PAX9 Mutant in Dental Pulp Stem Cells

Liu

Zhang

Zhao

et al. 2023

Gels

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Hypodontia (dental agenesis) is a genetic disorder, and it has been identified that the mutation C175T in PAX9 could lead to hypodontia. Cas9 nickase (nCas9)-mediated homology-directed repair (HDR) and base editing were used for the correction of this mutated point. This study aimed to investigate the effect of HDR and the base editor ABE8e in editing PAX9 mutant. It was found that the chitosan hydrogel was efficient in delivering naked DNA into dental pulp stem cells (DPSCs). To explore the influence of the C175T mutation in PAX9 on the proliferation of DPSCs, hydrogel was employed to deliver PAX9 mutant vector into DPSCs, finding that the PAX9-containing C175T mutation failed to promote the proliferation of DPSCs. Firstly, DPSCs stably carrying PAX9 mutant were constructed. Either an HDR or ABE8e system was delivered into the above-mentioned stable DPSCs, and then the correction efficiency using Sanger sequencing and Western blotting was determined. Meanwhile, the ABE8e presented significantly higher efficiency in correcting C175T compared with HDR. Furthermore, the corrected PAX9 presented enhanced viability and differentiation capacity for osteogenic and neurogenic lineages; the corrected PAX9 even possessed extremely enhanced transcriptional activation ability. In summary, this study has powerful implications for studies into base editors, chitosan hydrogel, and DPSCs in treating hypodontia.

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Section: Discussionmentioning

confidence: 99%

Chitosan Hydrogel-Delivered ABE8e Corrects PAX9 Mutant in Dental Pulp Stem Cells

Liu

Zhang

Zhao

et al. 2023

Gels

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“…[16] Similarly, the FT-IR analysis of PEP-AD revealed that a new peak appeared at 1567 cm −1 , which was attributed to the amine (─NH 2 ) groups of adipic dihydrazide (Figure S2B, Supporting Information). Further, 1 H NMR analysis for PEP-AD showed the characteristic chemical shifts of PEP-AD at 2.7(a), 1.5(b), 1.7(c), and 3.0(d) ppm (Figure S2C, Supporting Information). [17] These results suggested that OPEP and PEP-AD were successfully synthesized.…”

Section: Physicochemical Properties Of Opab Hydrogelmentioning

confidence: 99%

“…[2b,3] Among them, injectable hydrogels provide resolutions for repairing irregular wounds, such as tumor surgeryderived wounds, because they can perfectly fill the rough surfaces of these wounds and can be utilized in minimally invasive surgical treatments. [1,6] However, obstruction of injection tools due to postponed operation or spread of the hydrogel to surrounding tissues of wounds would usually occur. [7] The shearthinning property of an injectable hydrogel may offer solutions to these issues, because it can improve the viscous flow of hydrogel mixture before injection and ensure hydrogel to be injected easily via a syringe.…”

Section: Introductionmentioning

confidence: 99%

“…Cancer is the foremost cause of death worldwide, accounting for ≈10 million deaths annually. [ 1 ] For the majority of tumors, surgical resection is still the most common clinical treatment, particularly for solid tumors, such as liver and breast cancers. [ 1,2 ] However, major challenges still need to be addressed in solid tumor resection.…”

Section: Introductionmentioning

confidence: 99%

“…[ 1 ] For the majority of tumors, surgical resection is still the most common clinical treatment, particularly for solid tumors, such as liver and breast cancers. [ 1,2 ] However, major challenges still need to be addressed in solid tumor resection. First, ensuring intraoperative hemostasis during surgery is particularly important.…”

Section: Introductionmentioning

confidence: 99%

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Enteromorpha Prolifera Polysaccharide‐Derived Injectable Hydrogel for Fast Intraoperative Hemostasis and Accelerated Postsurgical Wound Healing Following Tumor Resection

Jiang,

Li,

Tian

et al. 2023

Adv Healthcare Materials

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Intraoperative bleeding and delayed postsurgical wound healing caused by persistent inflammation can increase the risk of tumor recurrence after surgical resection. To address these issues, Enteromorpha prolifera polysaccharide (PEP) with intrinsic potentials for hemostasis and wound healing, is chemically modified into aldehyde‐PEP and hydrazine‐PEP. Thereby, an injectable double‐network hydrogel (OPAB) is developed via forming dual dynamic bonding of acylhydrazone bonds between the decorated aldehyde and hydrazine groups and hydrogen bonds between hydroxyl groups between boric acid and PEP skeletons. The OPAB exhibits controllable shape‐adaptive gelation (35.0 s), suitable mechanical properties, nonstimulating self‐healing (60 s), good wet tissue adhesion (30.9 kPa), and pH‐responsive biodegradability. For in vivo models, owing to these properties, OPAB can achieve rapid hemostasis within 30 s for the liver hemorrhage, and readily loading of curcumin nanoparticles to remarkably accelerate surgical wound closure by alleviating inflammation, re‐epithelialization, granulation tissue formation, and collagen deposition. Overall, this multifunctional injectable hydrogel is a promising material that facilitates simultaneous intraoperative hemorrhage and postsurgical wound repair, holding significant potential in the clinical managements of bleeding and surgical wounds for tumor resection.

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Engineered Platelets for Cancer Therapy

Zhang,

Li,

et al. 2024

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While nanomedicine research shows a great progress in the treatment of cancer, it still faces challenges of tumor recurrence and metastasis. Numerous studies have demonstrated intricate crosstalk between platelets and tumor cells. The re‐education of platelets by tumor cells enables these platelets to provide critical assistance for tumor proliferation, recurrence, and metastasis. Engineered platelets have shown promising potential in the treatment of tumors, postoperative tumor recurrence, and tumor metastasis. Different engineering technologies such as surface modification, gene editing, membrane coating, and loading into hydrogels can produce multifunctional and customized engineered platelets. These engineered platelets inherit the key properties of platelets, including long blood circulation, tumor targeting, and thrombus targeting, and can be stimulated to generate derivatized particles. In this review, we elucidate the critical role of platelets in the complex processes of tumorigenesis and tumor progression and summarize the emerging paradigm of engineered platelets in tumor therapy. The purpose of this review is to comprehensively explore the potential value of engineered platelets toward the clinical treatment of cancer, providing a valuable reference for the further development of engineered platelets and their broader applications in the field of cancer therapy.

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Recent advances in hydrogels for preventing tumor recurrence

Abstract: Malignant tumors remain a high-risk disease with high mortality all over the world. Among all the cancer treatments, surgery is the primary approach in clinical treatment of tumors. However, tumor...

Cited by 8 publications

References 191 publications

Chitosan Hydrogel-Delivered ABE8e Corrects PAX9 Mutant in Dental Pulp Stem Cells

Chitosan Hydrogel-Delivered ABE8e Corrects PAX9 Mutant in Dental Pulp Stem Cells

Enteromorpha Prolifera Polysaccharide‐Derived Injectable Hydrogel for Fast Intraoperative Hemostasis and Accelerated Postsurgical Wound Healing Following Tumor Resection

Engineered Platelets for Cancer Therapy

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