Recent advances in hydroxyapatite-based electrochemical biosensors: Applications and future perspectives

Hartati, Yeni Wahyuni; Irkham, Irkham; Zulqaidah, Salsha; Syafira, Ratu Shifa; Kurnia, Irwan; Noviyanti, Atiek Rostika; Topkaya, Seda Nur

doi:10.1016/j.sbsr.2022.100542

Cited by 21 publications

(9 citation statements)

References 87 publications

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“…Hydroxyapatite (HAp) is the most important bioceramic material and the major component of all organic solid tissues appearing as the hexagonal symmetrical crystal system. It is commonly known to be used in many applications, for example in water purification (removal of heavy metals, defluorination), protein purification, polishing of monoclonal antibodies,, as catalyst in organic syntheses, or orthopedic and dental implant fabrication [1][2][3]. Pure artificial hydroxyapatite is synthetized by chemical reactions at high temperature [4].…”

Section: Introductionmentioning

confidence: 99%

EPR dosimetry of biohydroxyapatite below liquid nitrogen temperature

John,

Buryi,

Paurová

et al. 2024

J. Phys.: Conf. Ser.

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Hydroxyapatite, major component of all organic solid tissues, can be used as a sensitive biodosimeter based on the electron paramagnetic resonance (EPR) spectroscopy. However, the dosimetric signal of biohydroxyapatite overlaps with the so-called parasitic signals due to the close g factor values and broadening of the resonance line at room temperature. Moreover, the unsaturated parasitic signals possess the intensity comparable to the dosimetric resonance. All of these significantly complicates the dose determination and limits applicability mainly to the cases of relatively large accumulated dose. The negligibly saturated dosimteric spectrum can be at least partially separated at the liquid nitrogen temperatures (LNT) due to the strong saturation and suppression of the parasitic resonance lines and the linewidth shortening as shown in the present work. Moreover, the advances in the modern EPR equipment in the last two decades resulted in high sensitivity and stability of the signals measured. These are the key parameters along with the computer simulations for the precise dosimetric spectrum separation and processing. This could lead to the higher accuracy of the LNT EPR method proposed in the present work. To test the approach, the stepwise dose calibration of biohydroxyapatite over the range 0.5 - 20 Gy was made. The corresponding dosimetric signal measured at 70 K exhibited the linear dose response. The results suggest the applicability of the LNT EPR method in the retrospective dosimetry.

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Section: Introductionmentioning

confidence: 99%

EPR dosimetry of biohydroxyapatite below liquid nitrogen temperature

John,

Buryi,

Paurová

et al. 2024

J. Phys.: Conf. Ser.

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“…Researchers expanded the potential use of hydroxyapatite beyond traditional biomaterial roles, so HAp's composition, morphology, and surface characteristics have been tailored, resulting in enhanced mechanical strength, controlled drug release, and improved biodegradability. These changes broadened HAp's applicability to drug delivery systems [10], biosensors [11], tissue engineering scaffolds, and regenerative medicine [12,13]. The exceptional biomineralization properties of HAp facilitated the inclusion of functional ions and molecules during synthesis, leading to bioactive coatings and composites with specific therapeutic functionalities.…”

Section: Introductionmentioning

confidence: 99%

Hydroxyapatite Nanoparticles: A Review of Their Emerging Role in Drug Delivery Applications

PADURARU FILIP,

PADURARU,

ANDRONESCU

et al. 2024

AnnalsARSciPhysChem

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This literature review assesses existing research on hydroxyapatite-based drug delivery systems, with a focus on evaluating their effectiveness. Researchers are actively exploring strategies to enhance drug loading capacity, involving surface modifications of nanoparticles and the innovation of novel drug encapsulation techniques. Elevating drug loading has the potential to clearly increase the therapeutic efficacy of these systems. Stability issues also present a challenge in the clinical translation of nanoparticle-based drug delivery systems. Furthermore, scientists are underway to minimize potential side effects by judiciously selecting biocompatible materials for nanoparticle synthesis and conducting comprehensive toxicity studies before advancing to clinical trials.

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“…However, most of these techniques are expensive and time-consuming, and require skilled manpower, tedious sample pretreatment, and huge instrumentation setup [ 17 , 18 , 19 , 20 , 21 , 22 , 23 ]. Among them, the electrochemical biosensor is the most preferred technology due to its robustness, simplicity, rapidity, portability, cost-effectiveness, ease of handling, high sensitivity, and selectivity toward target analytes, in addition to reliable and reproducible responses [ 24 , 25 , 26 , 27 , 28 ]. In general, electrochemical sensing was performed in a three-electrode cell system composed of a modified working electrode (WE), reference electrode (RE), and counter electrode (CE).…”

Section: Introductionmentioning

confidence: 99%

Recent Developments in the Design and Fabrication of Electrochemical Biosensors Using Functional Materials and Molecules

Theyagarajan

Kim

2023

Biosensors

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Electrochemical biosensors are superior technologies that are used to detect or sense biologically and environmentally significant analytes in a laboratory environment, or even in the form of portable handheld or wearable electronics. Recently, imprinted and implantable biosensors are emerging as point-of-care devices, which monitor the target analytes in a continuous environment and alert the intended users to anomalies. The stability and performance of the developed biosensor depend on the nature and properties of the electrode material or the platform on which the biosensor is constructed. Therefore, the biosensor platform plays an integral role in the effectiveness of the developed biosensor. Enormous effort has been dedicated to the rational design of the electrode material and to fabrication strategies for improving the performance of developed biosensors. Every year, in the search for multifarious electrode materials, thousands of new biosensor platforms are reported. Moreover, in order to construct an effectual biosensor, the researcher should familiarize themself with the sensible strategies behind electrode fabrication. Thus, we intend to shed light on various strategies and methodologies utilized in the design and fabrication of electrochemical biosensors that facilitate sensitive and selective detection of significant analytes. Furthermore, this review highlights the advantages of various electrode materials and the correlation between immobilized biomolecules and modified surfaces.

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Recent advances in hydroxyapatite-based electrochemical biosensors: Applications and future perspectives

Cited by 21 publications

References 87 publications

EPR dosimetry of biohydroxyapatite below liquid nitrogen temperature

EPR dosimetry of biohydroxyapatite below liquid nitrogen temperature

Hydroxyapatite Nanoparticles: A Review of Their Emerging Role in Drug Delivery Applications

Recent Developments in the Design and Fabrication of Electrochemical Biosensors Using Functional Materials and Molecules

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