Recent Advances in Intraoperative Nerve Bioimaging: Fluorescence‐Guided Surgery for Nerve Preservation

Chen, Ying; Lei, Zuhai; Zhang, Fan

doi:10.1002/sstr.202000036

Cited by 35 publications

(24 citation statements)

References 110 publications

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“…Recently, NIR-II fluorescence-guided cancer surgery has been proven feasible clinically, which reduce cancer recurrence and promote the outcomes of cancer surgery 4 , 60 . To demonstrate that the strong NIR-II fluorescence signal of PCP-BDP2 endows its ability for image-guided cancer surgery, the peritoneal carcinomatosis-bearing mouse model was established, which scatter numerous tumor nodules of various sizes in the peritoneal cavity, especially those with diameters < 1 mm.…”

Section: Resultsmentioning

confidence: 99%

J-aggregates of meso-[2.2]paracyclophanyl-BODIPY dye for NIR-II imaging

et al. 2021

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J-aggregation is an efficient strategy for the development of fluorescent imaging agents in the second near-infrared window. However, the design of the second near-infrared fluorescent J-aggregates is challenging due to the lack of suitable J-aggregation dyes. Herein, we report meso-[2.2]paracyclophanyl-3,5-bis-N,N-dimethylaminostyrl BODIPY (PCP-BDP2) as an example of BODIPY dye with J-aggregation induced the second near-infrared fluorescence. PCP-BDP2 shows an emission maximum at 1010 nm in the J-aggregation state. Mechanism studies reveal that the steric and conjugation effect of the PCP group on the BODIPY play key roles in the J-aggregation behavior and photophysical properties tuning. Notably, PCP-BDP2 J-aggregates can be utilized for lymph node imaging and fluorescence-guided surgery in the nude mouse, which demonstrates their potential clinical application. This study demonstrates BODIPY dye as an alternate J-aggregation platform for developing the second near-infrared imaging agents.

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Section: Resultsmentioning

confidence: 99%

J-aggregates of meso-[2.2]paracyclophanyl-BODIPY dye for NIR-II imaging

et al. 2021

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“…Recently, NIR-II uorescence-guided cancer surgery has been proven feasible clinically, which reduce cancer recurrence and promote the outcomes of cancer surgery. 4,60 To demonstrate that the strong NIR-II uorescence signal of PCP-BDP2 endow its ability for image-guided cancer surgery, the peritoneal carcinomatosis-bearing mouse model was established, which scatter numerous tumor nodules of various sizes in the peritoneal cavity, especially those with diameters < 1 mm. After the PCP-BDP2 NPs were intravenously injected into the mice for 24 h, the surgery was rst performed by a surgeon by opening the mouse abdomen.…”

Section: Resultsmentioning

confidence: 99%

J-Aggregates of meso- [2.2] Paracyclophanyl-BODIPY Dye for NIR-II Imaging

Liu

Duan

et al. 2020

Preprint

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J-aggregation has been proved to be an efficient strategy for the development of fluorescent imaging agents in the second near-infrared (NIR-II, 1000–1700 nm) window. However, the design of NIR-II fluorescent J-aggregates is challenging due to the lack of suitable J-aggregation dyes. Herein, we report meso-[2.2]paracyclophanyl-3,5-bis-N,N-dimethylaminostyrl BODIPY (PCP-BDP2) as the first example of BODIPY dye with J-aggregation induced NIR-II fluorescence. PCP-BDP2 shows emission maximum at 795 nm in diluted solution and NIR-II emission at 1010 nm in the J-aggregation state. Mechanism studies reveal that the steric and conjugation effect of the PCP group on the BODIPY core plays key roles in the J-aggregation behavior and NIR-II fluorescence tuning. Notably, NIR-II emissive J-aggregates of PCP-BDP2 can be efficiently stabilized in the assembled nanoparticle. Taking advantage of high quantum yield and good photo-/chemo-stability, J-aggregates of PCP-BDP2 show high-resolution and long-term in vivo NIR-II imaging ability. Furthermore, J-aggregates of PCP-BDP2 can be utilized for lymph node imaging and fluorescence-guided surgery in the nude mouse, which demonstrates their potential clinical application. This study not only demonstrates BODIPY dye as a new J-aggregation platform for developing NIR-II imaging agents but also encourages further exploration on J-aggregation induced NIR-II emission of the other conventional organic dyes.

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“…[3][4][5] Surgical excision is widely used in current cancer treatments, but is associated with a high recurrence risk and unavoidable damage to the surrounding healthy tissue. [6][7][8] Non-surgical treatments, such as radiotherapy and chemotherapy, are also associated with substantial disadvantages, including radiation-induced inflammation, drug-induced injuries to the major organs, and a high recurrence rate. [9][10][11][12] Bone-related malignant tumors are frequently associated with osteolytic destruction and pathological fractures, which can complicate tumor treatment.…”

Section: Introductionmentioning

confidence: 99%

Injectable In Situ Induced Robust Hydrogel for Photothermal Therapy and Bone Fracture Repair

Liu

Sun

et al. 2021

Adv Funct Materials

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Malignant bone tumors are often accompanied by osteolytic destruction and severe pathological fractures. Current therapeutic strategies can largely inhibit tumor proliferation, but the high recurrence rate of tumors and related bone defects remain a significant challenge. This study aims to address these issues by developing a novel near‐infrared (NIR) light‐responsive and a mechanically strong hydrogel that offers excellent photothermal tumor therapy and bone fracture repair capabilities. The as‐prepared hydrogel exhibits good biocompatibility and an ultra‐strong photothermal effect due to the formation of a complex network with up‐conversion lanthanide‐Au hybrid nanoparticles and alginate molecules. A subcutaneous tumor model is used to demonstrate that tumors can be efficiently eradicated via local photothermal treatment, where there is no tumor recurrence within the observation period. Moreover, the injected hydrogel becomes mechanically strong due to in situ Ca2+ crosslinking, which provides a supportive matrix to promote the repair of bone defects via stabilization of the fractured bone structure. The high photothermal effect and robust support offered by this single material demonstrate the potential of using the proposed hydrogel for the simultaneous treatment of bone tumor removal and bone healing.

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Recent Advances in Intraoperative Nerve Bioimaging: Fluorescence‐Guided Surgery for Nerve Preservation

Cited by 35 publications

References 110 publications

J-aggregates of meso-[2.2]paracyclophanyl-BODIPY dye for NIR-II imaging

J-aggregates of meso-[2.2]paracyclophanyl-BODIPY dye for NIR-II imaging

J-Aggregates of meso- [2.2] Paracyclophanyl-BODIPY Dye for NIR-II Imaging

Injectable In Situ Induced Robust Hydrogel for Photothermal Therapy and Bone Fracture Repair

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