Recent advances in itaconic acid production from microbial cell factories

Gopaliya, Deeksha; Kumar, Vinod; Khare, Sunil Kumar

doi:10.1016/j.bcab.2021.102130

Cited by 38 publications

(37 citation statements)

References 120 publications

(144 reference statements)

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“…Itaconic acid can be considered mainly as a chemical building block, as it is exclusively used in non-food applications. It is used in styrene-butadiene rubber, synthetic latex, methyl methacrylate (MMA), unsaturated polyester resins (UPR), and as a chelant dispersant [101,102].…”

Section: From First Evidence and Studies To Current Pilot Or Commerci...mentioning

confidence: 99%

“…Itaconic acid is produced in about 41.400 tons/y. The first industry plant was founded by Pfizer Co. Inc (Brooklyn, 1955), which also developed a patented aerobic fermentation process to produce itaconic acid [101]. While in the past decades the majority of the itaconic acid production was ascribable to companies located in different parts of the world, such as Cargill, Iwata Chemicals and Melle, currently it is completely in the hands of Chinese industries [105,106].…”

Section: From First Evidence and Studies To Current Pilot Or Commerci...mentioning

confidence: 99%

“…In addition, most residual biomasses require pre-treatment steps in order to be metabolized by the cells. A recent review about itaconic acid [101] reported different IA producer strains (native or not) modified in order to exploit some residual biomasses as alternative carbon sources.…”

Section: From First Evidence and Studies To Current Pilot Or Commerci...mentioning

confidence: 99%

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State of the Art on the Microbial Production of Industrially Relevant Organic Acids

et al. 2022

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The industrial relevance of organic acids is high; because of their chemical properties, they can be used as building blocks as well as single-molecule agents with a huge annual market. Organic acid chemical platforms can derive from fossil sources by petrochemical refining processes, but most of them also represent natural metabolites produced by many cells. They are the products, by-products or co-products of many primary metabolic processes of microbial cells. Thanks to the potential of microbial cell factories and to the development of industrial biotechnology, from the last decades of the previous century, the microbial-based production of these molecules has started to approach the market. This was possible because of a joint effort of microbial biotechnologists and biochemical and process engineers that boosted natural production up to the titer, yield and productivity needed to be industrially competitive. More recently, the possibility to utilize renewable residual biomasses as feedstock not only for biofuels, but also for organic acids production is further augmenting the sustainability of their production, in a logic of circular bioeconomy. In this review, we briefly present the latest updates regarding the production of some industrially relevant organic acids (citric fumaric, itaconic, lactic and succinic acid), discussing the challenges and possible future developments of successful production.

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Section: From First Evidence and Studies To Current Pilot Or Commerci...mentioning

confidence: 99%

Section: From First Evidence and Studies To Current Pilot Or Commerci...mentioning

confidence: 99%

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State of the Art on the Microbial Production of Industrially Relevant Organic Acids

et al. 2022

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“…Itaconic acid is known to be produced from filamentous fungi, Aspergillus terreus [190]. Current advances in itaconic acid fermentation lie in the development of non-filamentous engineered strains, e.g., E. coli, Ustilago maydis, and Y. lipolytica, which tolerate high titers to improve feasibility in large-scale production [191,192].…”

Section: Itaconic Acidmentioning

confidence: 99%

Contribution of Fermentation Technology to Building Blocks for Renewable Plastics

Lomwongsopon

Varrone

2022

Fermentation

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Large-scale worldwide production of plastics requires the use of large quantities of fossil fuels, leading to a negative impact on the environment. If the production of plastic continues to increase at the current rate, the industry will account for one fifth of global oil use by 2050. Bioplastics currently represent less than one percent of total plastic produced, but they are expected to increase in the coming years, due to rising demand. The usage of bioplastics would allow the dependence on fossil fuels to be reduced and could represent an opportunity to add some interesting functionalities to the materials. Moreover, the plastics derived from bio-based resources are more carbon-neutral and their manufacture generates a lower amount of greenhouse gasses. The substitution of conventional plastic with renewable plastic will therefore promote a more sustainable economy, society, and environment. Consequently, more and more studies have been focusing on the production of interesting bio-based building blocks for bioplastics. However, a coherent review of the contribution of fermentation technology to a more sustainable plastic production is yet to be carried out. Here, we present the recent advancement in bioplastic production and describe the possible integration of bio-based monomers as renewable precursors. Representative examples of both published and commercial fermentation processes are discussed.

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“…Adapted fromKugler et al (2019) Metabolic pathway for the biosynthesis of itaconic acid. Adapted fromGopaliyaa et al (2021)…”

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confidence: 99%

Surfactants produced from carbohydrate derivatives: A review of the biobased building blocks used in their synthesis

Ortiz

Alvarado

Zambrano³

et al. 2022

J Surfact & Detergents

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This work reviews the use of carbohydrates and their derivatives as renewable raw materials in the production of surfactants. Methods to attain state‐of‐the‐art carbohydrate‐derived surfactants are described. This includes surfactants widely used nowadays and others that have not yet transcended beyond the academic field. Given the abundance of hydroxyl groups in carbohydrates and the considerable quantity of different surfactant structures that can be generated during their synthesis, selectively obtaining a target product represents a challenge. Therefore, this work focuses on the platform chemicals available to synthesize biobased surfactants. The first part of the review comprises a brief introduction of simple and complex carbohydrates to better understand their chemistry. Then, a description of the processes to obtain biobased building blocks derived from carbohydrates according to the National Renewable Energy Laboratory (NREL, USA), and their usefulness in synthesizing surfactants is presented. This provides an organized inventory of the knowledge around the synthesis–production of surfactants from carbohydrate derivatives, emphasizing raw materials that could be inserted into the circular bioeconomy concept. Finally, the current industry trends and the potential role of biobased surfactants around new dioxane regulations are discussed.

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Recent advances in itaconic acid production from microbial cell factories

Cited by 38 publications

References 120 publications

State of the Art on the Microbial Production of Industrially Relevant Organic Acids

State of the Art on the Microbial Production of Industrially Relevant Organic Acids

Contribution of Fermentation Technology to Building Blocks for Renewable Plastics

Surfactants produced from carbohydrate derivatives: A review of the biobased building blocks used in their synthesis

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