Recent Advances in Magnetite Nanoparticle Functionalization for Nanomedicine

Popescu, Roxana Cristina; Andronescu, Ecaterina; Vasile, Bogdan Ștefan

doi:10.3390/nano9121791

Cited by 93 publications

(67 citation statements)

References 268 publications

(245 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The hydrothermal methods are increasingly used for the preparation of MNPs because of their versatility in obtaining crystalline particles with controlled size and morphology in reasonable cost and good yield [ 59 , 60 ]. In the present work, four different nanoparticle morphologies were obtained using this method: spheres (SP), cubes (CU), rods (RO), and stars (ST).…”

Section: Resultsmentioning

confidence: 99%

Modulation of the Magnetic Hyperthermia Response Using Different Superparamagnetic Iron Oxide Nanoparticle Morphologies

2021

View full text Add to dashboard Cite

The use of magnetic nanoparticles in hyperthermia, that is, heating induced by alternating magnetic fields, is gaining interest as a non-invasive, free of side effects technique that can be considered as a co-adjuvant of other cancer treatments. Having sufficient control on the field characteristics, within admissible limits, the focus is presently on the magnetic material. In the present contribution, no attempt has been made of using other composition than superparamagnetic iron oxide nanoparticles (SPION), or of applying surface functionalization, which opens a wider range of choices. We have used a hydrothermal synthesis route that allows preparing SPION nanoparticles in the 40 nm size range, with spherical, cuboidal or rod-like shapes, by minor changes in the synthesis steps. The three kinds of particles (an attempt to produce star-shaped colloids yielded hematite) were demonstrated to have the magnetite (or maghemite) crystallinity. Magnetization cycles showed virtually no hysteresis and demonstrated the superparamagnetic nature of the particles, cuboidal ones displaying saturation magnetization comparable to bulk magnetite, followed by rods and spheres. The three types were used as hyperthermia agents using magnetic fields of 20 kA/m amplitude and frequency in the range 136–205 kHz. All samples demonstrated to be able to raise the solution temperature from room values to 45 °C in a mere 60 s. Not all of them performed the same way, though. Cuboidal magnetic nanoparticles (MNPs) displayed the maximum heating power (SAR or specific absorption rate), ranging in fact among the highest reported with these geometries and raw magnetite composition.

show abstract

Section: Resultsmentioning

confidence: 99%

Modulation of the Magnetic Hyperthermia Response Using Different Superparamagnetic Iron Oxide Nanoparticle Morphologies

2021

View full text Add to dashboard Cite

show abstract

“…Since the validation of ferrimagnetic iron oxide magnetic nanoparticles, IOMNPs (magnetite-Fe 3 O 4 or maghemite-Fe 2 O 3 ), by the U.S. Food and Drug Administration [1], this class of magnetic nanoparticles has been the subject of intense research for their potentiality in a widespread number of biomedical and pharmaceutical applications [2][3][4][5][6]. To be efficient as vectors for targeted drug delivery, contrast agents in magnetic resonance imaging (MRI) and heating mediators in magnetic hyperthermia (MH), the IOMNPs should possess a maximum value of saturation magnetization (M s ) and minimum value of coercive field (H c ) and remnant magnetization (M r ) [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

In Vitro Intracellular Hyperthermia of Iron Oxide Magnetic Nanoparticles, Synthesized at High Temperature by a Polyol Process

et al. 2020

View full text Add to dashboard Cite

We report the synthesis of magnetite nanoparticles (IOMNPs) using the polyol method performed at elevated temperature (300 °C) and high pressure. The ferromagnetic polyhedral IOMNPs exhibited high saturation magnetizations at room temperature (83 emu/g) and a maximum specific absorption rate (SAR) of 2400 W/gFe in water. The uniform dispersion of IOMNPs in solid matrix led to a monotonous increase of SAR maximum (3600 W/gFe) as the concentration decreased. Cytotoxicity studies on two cell lines (cancer and normal) using Alamar Blues and Neutral Red assays revealed insignificant toxicity of the IOMNPs on the cells up to a concentration of 1000 μg/mL. The cells internalized the IOMNPs inside lysosomes in a dose-dependent manner, with higher amounts of IOMNPs in cancer cells. Intracellular hyperthermia experiments revealed a significant increase in the macroscopic temperatures of the IOMNPs loaded cell suspensions, which depend on the amount of internalized IOMNPs and the alternating magnetic field amplitude. The cancer cells were found to be more sensitive to the intracellular hyperthermia compared to the normal ones. For both cell lines, cells heated at the same macroscopic temperature presented lower viability at higher amplitudes of the alternating magnetic field, indicating the occurrence of mechanical or nanoscale heating effects.

show abstract

“…10,11 As a result, IONs have been limited in application to the enrichment of the biological entities with conjugation to optical biomarkers, such as uorescent molecules, for readout. [12][13][14][15] Unfortunately, IONs also have weak magnetic properties that limit their use in ultralow enrichment and multiplexing applications. 7 In this paper, we propose ferromagnetic nanowires (MNWs) as biomarkers for multiplexing applications.…”

Section: Introductionmentioning

confidence: 99%

Projection method as a probe for multiplexing/demultiplexing of magnetically enriched biological tissues

Kouhpanji

Stadler

2020

RSC Adv.

View full text Add to dashboard Cite

show abstract

Recent Advances in Magnetite Nanoparticle Functionalization for Nanomedicine

Cited by 93 publications

References 268 publications

Modulation of the Magnetic Hyperthermia Response Using Different Superparamagnetic Iron Oxide Nanoparticle Morphologies

Modulation of the Magnetic Hyperthermia Response Using Different Superparamagnetic Iron Oxide Nanoparticle Morphologies

In Vitro Intracellular Hyperthermia of Iron Oxide Magnetic Nanoparticles, Synthesized at High Temperature by a Polyol Process

Projection method as a probe for multiplexing/demultiplexing of magnetically enriched biological tissues

Contact Info

Product

Resources

About