Recent advances in managing Peyronie’s disease

Abstract

Treating men with Peyronie’s disease remains a challenging problem facing clinicians working across urology and sexual medicine fields. Patients can often be left disappointed by current treatment paradigms, and an overall lack of suitable molecular targets has limited the options for novel, effective medical therapy. Managing men with Peyronie’s disease often involves careful counselling alongside multifaceted and possible combination treatments to help improve symptoms whilst ameliorating potential side effects of therapy. We review the latest medical literature and evidence in the contemporary management of Peyronie’s disease.

A systematic review of non-surgical management in Peyronieʼs disease

“…In many studies looking at the efficacy of surgical treatment options for PD there is a lack of validated patient-reported outcomes looking at things such as the psychological impact of treatment, this partly explains why the American Urological Association guidelines for the treatment of PD rate the evidence basis for surgical treatment poorly [ 1 ]. However patient morbidity associated with surgery has led to increasing interest in medical interventions for PD, for example in cases of recurrent or residual curvature [ 71 ].…”

Peyronie’s Disease

“…Peyronie's disease (PD), also known as induration penis plastica (IPP), is a clinical condition characterized by the formation of fibrotic plaques onto the tunica albuginea of the penis, which may result into abnormal penile curvature and deformity, erectile dysfunction (ED), and loss of penile length. The combination of these events may result in the impossibility of performing penetrative intercourse [1].…”