Recent advances in metal-free catalytic enantioselective higher-order cycloadditions

Zhang, Bei; Wang, Jian

doi:10.1039/d4qo00017j

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Cited by 5 publications

References 104 publications

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Tropone Hydrazides in [10+2]‐Hetero‐Higher‐Order Cycloaddition for the Synthesis of Tetrahydropyridazine Derivatives

Cieśliński,

Przydacz,

Sieroń

et al. 2024

Adv Synth Catal

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[10+2]‐Hetero‐higher‐order cycloaddition between tropone hydrazides (acting as 10π‐components) and 3‐alkylidene oxindoles (acting as 2π‐components) has been established. Under Brønsted base catalysis the reaction proceeded in a fully peri‐ and diastereoselective manner with the stereochemical outcome governed mainly by electronic interactions. Following such a strategy, a series of structurally diverse tetrahydropyridazines were prepared in 30‐70% yields. Furthermore, the potential of the obtained cycloadducts has been confirmed in selected chemoselective transformations.

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Tropone Hydrazides in [10+2]‐Hetero‐Higher‐Order Cycloaddition for the Synthesis of Tetrahydropyridazine Derivatives

Cieśliński,

Przydacz,

Sieroń

et al. 2024

Adv Synth Catal

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show abstract

Triquinane based natural products via cycloadditions and metathesis

Cheekatla

2024

Tetrahedron Chem

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Catalyst-controlled switchable formal retro-Büchner reaction for the divergent synthesis of benzo[b]azepines and 1, 3-conjugated dienes

Wang,

Guo,

et al. 2025

Tetrahedron

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Recent advances in metal-free catalytic enantioselective higher-order cycloadditions

Abstract: Higher-order cycloadditions (HOCs) present notable benefits for the synthesis of complex molecules, particularly those featuring medium size and multiple rings. The research of HOCs has experienced remarkable advancements since the...

Cited by 5 publications

References 104 publications

Tropone Hydrazides in [10+2]‐Hetero‐Higher‐Order Cycloaddition for the Synthesis of Tetrahydropyridazine Derivatives

Tropone Hydrazides in [10+2]‐Hetero‐Higher‐Order Cycloaddition for the Synthesis of Tetrahydropyridazine Derivatives

Triquinane based natural products via cycloadditions and metathesis

Catalyst-controlled switchable formal retro-Büchner reaction for the divergent synthesis of benzo[b]azepines and 1, 3-conjugated dienes

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