Recent advances in microfluidic-aided chitosan-based multifunctional materials for biomedical applications

Gao, Yang; Ma, Qingming; Cao, Jie; Wang, Yiwen; Yang, Xin; Xu, Qiulong; Liang, Qing; Sun, Yong

doi:10.1016/j.ijpharm.2021.120465

Cited by 42 publications

(17 citation statements)

References 153 publications

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“…Other preparation techniques include, but are not limited to, sonication [69,70], electrospraying [71], electrostatic gelation [72][73][74], extrusion of polymer dispersions [75], selfassembly of polysaccharides [65], and microfluidic methods [76,77].…”

Section: Preparation Methodsmentioning

confidence: 99%

Applications of Chitosan-Alginate-Based Nanoparticles—An Up-to-Date Review

2022

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Chitosan and alginate are two of the most studied natural polymers that have attracted interest for multiple uses in their nano form. The biomedical field is one of the domains benefiting the most from the development of nanotechnology, as increasing research interest has been oriented to developing chitosan-alginate biocompatible delivery vehicles, antimicrobial agents, and vaccine adjuvants. Moreover, these nanomaterials of natural origin have also become appealing for environmental protection (e.g., water treatment, environmental-friendly fertilizers, herbicides, and pesticides) and the food industry. In this respect, the present paper aims to discuss some of the newest applications of chitosan-alginate-based nanomaterials and serve as an inception point for further research in the field.

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Section: Preparation Methodsmentioning

confidence: 99%

Applications of Chitosan-Alginate-Based Nanoparticles—An Up-to-Date Review

2022

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“…Consequently, the accurate relationships between physicochemical properties and performance of the fabricated CS-based materials cannot be systematically investigated, which further hampers their applications. Besides these drawbacks, the conventional methods are highly complex and therefore difficult in scale-up production [101].…”

Section: Microfluidic Methodsmentioning

confidence: 99%

“…For example, the concentration of CS, molecular weight and deacetylation degree of CS, and type of derivatives of CS can affect the physical properties of the CS solution like density, viscosity, and surface tension [105]. Under the same flow rate and pressure, the thickness of the CS liquid layer and the size of the droplets in the microfluidic channel may also be affected [101].…”

Section: Microfluidic Methodsmentioning

confidence: 99%

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Mikušová

Mikuš

2021

IJMS

295

120

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Nanoparticles (NPs) have an outstanding position in pharmaceutical, biological, and medical disciplines. Polymeric NPs based on chitosan (CS) can act as excellent drug carriers because of some intrinsic beneficial properties including biocompatibility, biodegradability, non-toxicity, bioactivity, easy preparation, and targeting specificity. Drug transport and release from CS-based particulate systems depend on the extent of cross-linking, morphology, size, and density of the particulate system, as well as physicochemical properties of the drug. All these aspects have to be considered when developing new CS-based NPs as potential drug delivery systems. This comprehensive review is summarizing and discussing recent advances in CS-based NPs being developed and examined for drug delivery. From this point of view, an enhancement of CS properties by its modification is presented. An enhancement in drug delivery by CS NPs is discussed in detail focusing on (i) a brief summarization of basic characteristics of CS NPs, (ii) a categorization of preparation procedures used for CS NPs involving also recent improvements in production schemes of conventional as well as novel CS NPs, (iii) a categorization and evaluation of CS-based-nanocomposites involving their production schemes with organic polymers and inorganic material, and (iv) very recent implementations of CS NPs and nanocomposites in drug delivery.

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“…[95] The gelation speed of natural polysaccharide materials, such as alginate (alg), hyaluronic acid (HA), chitosan (CS), dextran (Dex), and cellulose, is fast. [96][97][98][99][100][101] CS with high adsorption capacity, biocompatibility, and biodegradation, is a commonly used polysaccharide biopolymer derived from chitin. [102] The interface characteristics of MPRs prepared from CS are detailed as follows.…”

Section: Mprs Prepared By Physical Conversion Of Materials and Their ...mentioning

confidence: 99%

Microfluidic Particle Reactors: From Interface Characteristics to Cells and Drugs Related Biomedical Applications

Xin

et al. 2022

Adv Materials Inter

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with advanced functions, [6] can be attributed to two aspects. 1) The exquisite control and manipulation abilities of fluids at a microscale have reached a new height as droplet microfluidic technology is leaping forward. The precisely tunable interface characteristics of emulsion templates, determined by the optimization of fluids composition and interfacial complexity, contribute to the inherent interface properties of MPRs. [7][8][9][10] 2) The introduction of advanced materials expands the interface characteristics of the MPRs. Considerable natural polymers, synthetic polymers, and stimuli-responsive biomaterials have been employed continuously with the development of materials science. As a result, a series of performances possessed by the materials can significantly improve the inherent interface characteristics of the MPRs under a combination of the mentioned advanced materials. [11][12][13][14][15][16] Overall, researchers have stressed the improvement of the development process of interface characteristics and functions (such as substance encapsulation and controlled release) by providing novel technical innovations in every aspect to support biomedical clinical applications related to cells and drugs. Recently, the types, preparation methods, and biomedical applications of MPRs have been systematically presented in several excellent reviews. [3][4][5][8][9][10][17][18][19][20] The thermodynamic properties of liquid-liquid droplet reactors have been analyzed more specifically in some reviews. [7,17] However, the origin of interface characteristics of MPRs, as well as the function and cuttingedge cell-and drug-related biomedical applications determined by the interface characteristics, are deficient in a systematic summary. This review highlights that different emulsion templates endow the inherent interface characteristics of MPRs. Besides, the methods of converting emulsion templates into MPRs are summarized by introducing specific functional biomaterials, followed by the flexible and adjustable interface characteristics expanded by the mentioned materials. Moreover, the biomedical applications related to cells and drugs are analyzed based on the mentioned unique interface characteristics of the MPRs. Furthermore, the existing challenges regarding the current status are presented, and the subsequent development of the MPRs is illustrated from various perspectives (Scheme 1).

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Recent advances in microfluidic-aided chitosan-based multifunctional materials for biomedical applications

Cited by 42 publications

References 153 publications

Applications of Chitosan-Alginate-Based Nanoparticles—An Up-to-Date Review

Applications of Chitosan-Alginate-Based Nanoparticles—An Up-to-Date Review

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Microfluidic Particle Reactors: From Interface Characteristics to Cells and Drugs Related Biomedical Applications

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