Recent advances in modelling and control of liquid chromatography

Abstract

For more than a century, chromatography has been indispensable as a separation method for both analytics and purification. Among the variety of chromatographic techniques, liquid chromatography has a special status owing to its efficiency and versatility, and its status is further enhanced by the continuous improvements of analysers, materials, methods and understanding, all supported by computational approaches. High performance liquid chromatography (HPLC) has always held a special place in pharmaceutical processing, and computational HPLC has been explored since the very early stages of computing, although without having yet reached its full potential. Herein, we provide a comprehensive and critical review of recent developments in designing and operating liquid chromatographic systems, focussing on their modelling approaches and control strategies at large scale.

A high‐performance liquid chromatography method for simultaneous quantification of metformin and ferulic acid in solid dosage forms

“…Metformin has pkA 12.4 (basic) and log P −2.6, showing no problem with solubility in aqueous media. The presence of several amino groups makes MT highly basic and polar, so, from the point of view of LC, a more careful approach to this molecule is necessary for its interaction in RP [5,6,14], the most widespread type of HPLC to date [15,16].…”