Recent advances in nanoantibiotics against multidrug-resistant bacteria

Li, Mulan; Liu, Ying; Gong, Youhuan; Yan, Xiaojie; Wang, Le; Zheng, Wenfu; Ai, Hao; Zhao, Yuliang

doi:10.1039/d3na00530e

Cited by 7 publications

(1 citation statement)

References 386 publications

(418 reference statements)

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“…Pharmacologists play a crucial role in studying the pharmacokinetics and pharmacodynamics of antimicrobial agents, helping to optimize dosages and treatment regimens. Social scientists contribute valuable perspectives on behavioral factors, public awareness, and healthcare infrastructure, influencing the success of interventions [66]. This interdisciplinary collaboration not only broadens the scope of research but also enhances the potential for innovative solutions.…”

Section: Interdisciplinary Researchmentioning

confidence: 98%

ESKAPE: Navigating the Global Battlefield for Antimicrobial Resistance and Defense in Hospitals

Ravi,

Singh

2024

Bacteria

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The current healthcare environment is at risk due to the facilitated transmission and empowerment of the ESKAPE pathogens, comprising of Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species. These pathogens have posed significant challenges to global public health and the threat has only amplified over time. These multidrug-resistant bacteria have become adept at escaping the effects of conventional antibiotics utilized, leading to severe healthcare-associated infections and compromising immunocompromised patient outcomes to a greater extent. The impact of ESKAPE pathogens is evident in the rapidly rising rates of treatment failures, increased mortality, and elevated healthcare costs. To combat this looming crisis, diverse strategies have been adopted, ranging from the development of novel antimicrobial agents and combination therapies to the implementation of stringent infection control measures. Additionally, there has been a growing emphasis on promoting antimicrobial stewardship programs to optimize the use of existing antibiotics and reduce the selective pressure driving the evolution of resistance. While progress has been made to some extent, the rapid adaptability of these pathogens and the enhancement of antimicrobial resistance mechanisms proves to be a major hurdle yet to be crossed by healthcare professionals. In this viewpoint, the impending threat heralded by the proliferation of ESKAPE pathogens, and the need for a concerted global effort via international collaborations for the assurance of effective and sustainable solutions, are explored. To curb the possibility of outbreaks in the future and to safeguard public health, better preparation via global awareness and defense mechanisms should be given paramount importance.

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Section: Interdisciplinary Researchmentioning

confidence: 98%

ESKAPE: Navigating the Global Battlefield for Antimicrobial Resistance and Defense in Hospitals

Ravi,

Singh

2024

Bacteria

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Clinically Relevant Metallic Nanoparticles in Tuberculosis Diagnosis and Therapy

Akinnawo,

Dube

2024

Advanced Therapeutics

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Globally a significant burden of tuberculosis (TB) is faced, which is difficult to eradicate due to patients' non‐adherence, and drug‐resistant strains that are spreading at an alarming rate. Novel approaches are required to improve diagnosis and treatment. Metallic nanoparticles (MNPs) have demonstrated potential as sensor probes and in combination therapy, which combines MNPs with antimycobacterial drugs to develop new treatment and theranostic approaches. To strengthen the theoretical foundation toward the clinical application of TB nanomedicine, this review focuses on the properties and effectiveness of therapeutically relevant MNPs. It also elaborates on their antimycobacterial mechanisms. This review aims to analyze the body of literature on the topic, pinpoint important empirical findings, and identify knowledge gaps that can provide a basis for future research endeavors and translation of the technologies. Current data suggest that MNPs are potential systems for efficient diagnosis and treatment although additional pre‐clinical and clinical research is needed to bring these technologies to the clinic.

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Quercetin disrupts biofilm formation and attenuates virulence of Aeromonas hydrophila

Jayaraman,

Rajendhran,

Kannan

et al. 2024

Arch Microbiol

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Recent advances in nanoantibiotics against multidrug-resistant bacteria

Abstract: Multidrug-resistant (MDR) bacteria-caused infections have been a major threat to human health. The abuse of conventional antibiotics accelerates the generation of MDR bacteria and makes the situation worse. The emergence...

Cited by 7 publications

References 386 publications

ESKAPE: Navigating the Global Battlefield for Antimicrobial Resistance and Defense in Hospitals

ESKAPE: Navigating the Global Battlefield for Antimicrobial Resistance and Defense in Hospitals

Clinically Relevant Metallic Nanoparticles in Tuberculosis Diagnosis and Therapy

Quercetin disrupts biofilm formation and attenuates virulence of Aeromonas hydrophila

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