Recent advances in nanoparticle applications in respiratory disorders: a review

Abstract

Various nanoparticles are used in the discovery of new nanomedicine to overcome the shortages of conventional drugs. Therefore, this article presents a comprehensive and up-to-date review of the effects of nanoparticle-based drugs in the treatment of respiratory disorders, including both basic and clinical studies. Databases, including PubMed, Web of Knowledge, and Scopus, were searched until the end of August 2022 regarding the effect of nanoparticles on respiratory diseases. As a new tool, nanomedicine offered promising applications for the treatment of pulmonary diseases. The basic composition and intrinsic characteristics of nanomaterials showed their effectiveness in treating pulmonary diseases. The efficiency of different nanomedicines has been demonstrated in experimental animal models of asthma, chronic obstructive pulmonary disease (COPD), pulmonary fibrosis (PF), lung cancer, lung infection, and other lung disorders, confirming their function in the improvement of respiratory disorders. Various types of nanomaterials, such as carbon nanotubes, dendrimers, polymeric nanomaterials, liposomes, quantum dots, and metal and metal oxide nanoparticles, have demonstrated therapeutic effects on respiratory disorders, which may lead to new possible remedies for various respiratory illnesses that could increase drug efficacy and decrease side effects.

Optimization of Dendritic Polypeptide Delivery System for Antisense Antibacterial Agents Targeting ftsZ

“…Dendritic polypeptides (DPPs), as a dendritic hyperbranched structure, can be designed to be a more efficient drug transport vehicle by changing the functional group of the hydrophilic or hydrophobic region. 30 In our previous work, we designed a series of DPPs to form nanocomplexes with ASOs by noncovalent interaction, followed by stabilizing by DSPE-mPEG2000 to get the nanodelivery system (DP-AD). DP-AD7 8:1 and DP-AD8 8:1 were screened, which could effectively deliver ASOs into different bacterial strains and achieve effective antibacterial activity both in vitro and in vivo.…”