Recent advances in nanoparticle-based targeting tactics for antibacterial photodynamic therapy

Thomas-Moore, Brydie A.; Valle, Carla Arnau del; Field, Robert A.; Marín, María J.

doi:10.1007/s43630-022-00194-3

Cited by 23 publications

(20 citation statements)

References 109 publications

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“…In addition, nanomaterials have the potential to act as nanocarriers, which would allow for the delivery of medicinal substances. Nanomaterials’ methods directly result from the one-of-a-kind physicochemical features they possess, particularly their multivalent interactions with bacterial cells. , At the interfaces of nanomaterials and bacteria, several forces, including hydrophobic interactions, receptor–ligand interactions, electrostatic attractions, and van der Waals forces, all play essential roles.…”

Section: Antimicrobial Mechanism Of Nanoparticlesmentioning

confidence: 99%

Perspectives on Usage of Functional Nanomaterials in Antimicrobial Therapy for Antibiotic-Resistant Bacterial Infections

et al. 2023

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The clinical applications of nanotechnology are emerging as widely popular, particularly as a potential treatment approach for infectious diseases. Diseases associated with multiple drug-resistant organisms (MDROs) are a global concern of morbidity and mortality. The prevalence of infections caused by antibiotic-resistant bacterial strains has increased the urgency associated with researching and developing novel bactericidal medicines or unorthodox methods capable of combating antimicrobial resistance. Nanomaterial-based treatments are promising for treating severe bacterial infections because they bypass antibiotic resistance mechanisms. Nanomaterial-based approaches, especially those that do not rely on small-molecule antimicrobials, display potential since they can bypass drug-resistant bacteria systems. Nanoparticles (NPs) are small enough to pass through the cell membranes of pathogenic bacteria and interfere with essential molecular pathways. They can also target biofilms and eliminate infections that have proven difficult to treat. In this review, we described the antibacterial mechanisms of NPs against bacteria and the parameters involved in targeting established antibiotic resistance and biofilms. Finally, yet importantly, we talked about NPs and the various ways they can be utilized, including as delivery methods, intrinsic antimicrobials, or a mixture.

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Section: Antimicrobial Mechanism Of Nanoparticlesmentioning

confidence: 99%

Perspectives on Usage of Functional Nanomaterials in Antimicrobial Therapy for Antibiotic-Resistant Bacterial Infections

et al. 2023

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“…On the other hand, Gram-negative bacteria have a polysaccharide membrane above the peptidoglycan layer [47,51]. Upon semiconductor activation, the ROS oxidize the peptidoglycan layer and the polysaccharide layer, facilitating the reduction in cell viability in the system [52,53]. Cell membrane destruction can also occur through the interaction between microbes and particles from the deposition of bacteria on the semiconductor agglomerate [30].…”

Section: Gkt + Hν → Gkt + E + Hmentioning

confidence: 99%

“…The direct interaction between bacteria and GKT showed a better inhibitory effect on S. Aureus bacteria. The thicker peptidoglycan layer offered more excellent resistance to the TiO 2 /Karaya composite than the thin layer of peptidoglycan in E.coli around the lipopolysaccharide layer (LPS) [52].…”

Section: Gkt + Hν → Gkt + E + Hmentioning

confidence: 99%

TiO2/Karaya Composite for Photoinactivation of Bacteria

et al. 2022

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A TiO2/Karaya composite was synthesized by the sol-gel method for the photoinactivation of pathogens. This is the first time that we have reported this composite for an antimicrobial approach. The structure, morphology, and optical properties were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-rays (EDS), Fourier transform infrared spectroscopy (FTIR), and diffuse reflectance, and the surface area was characterized by the BET method. The XRD and EDS results showed that the TiO2/Karaya composite was successfully stabilized by the crystal structure and pore diameter distribution, indicating a composite of mesoporous nature. Furthermore, antibacterial experiments showed that the TiO2/Karaya composite under light was able to photo-inactivate bacteria. Therefore, the composite is a promising candidate for inhibiting the growth of bacteria.

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“…Photodynamic therapy (PDT) is a treatment that uses a nontoxic photosensitizer (PS) that can be activated by a specific wavelength of light, usually from a laser or light-emitting diode (LED), to generate reactive oxygen species (ROS) and destroy cancerous cells or inactivate pathogens. Photosensitizers (PSs) in photodynamic antimicrobial chemotherapy (PACT) are rapidly developing and have been applied to inactivate and inhibit the replication of protozoa, fungi, bacteria, and viruses [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 ]. Viruses are the most diverse biological entities, and light-activated compounds that have been shown to be effective against some viruses may be ineffective against others.…”

Section: Introductionmentioning

confidence: 99%

Photodynamic Inhibition of Herpes Simplex Virus 1 Infection by Tricationic Amphiphilic Porphyrin with a Long Alkyl Chain

et al. 2023

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Photodynamic therapy (PDT) is broadly used to treat different tumors, and it is a rapidly developing approach to inactivating or inhibiting the replication of fungi, bacteria, and viruses. Herpes simplex virus 1 (HSV-1) is an important human pathogen and a frequently used model to study the effects of PDT on enveloped viruses. Although many photosensitizers (PSs) have been tested for their antiviral properties, analyses are usually limited to assessing the reduction in viral yield, and thus the molecular mechanisms of photodynamic inactivation (PDI) remain poorly understood. In this study, we investigated the antiviral properties of TMPyP3-C17H35, a tricationic amphiphilic porphyrin-based PS with a long alkyl chain. We show that light-activated TMPyP3-C17H35 can efficiently block virus replication at certain nM concentrations without exerting obvious cytotoxicity. Moreover, we show that the levels of viral proteins (immediate-early, early, and late genes) were greatly reduced in cells treated with subtoxic concentrations of TMPyP3-C17H35, resulting in markedly decreased viral replication. Interestingly, we observed a strong inhibitory effect of TMPyP3-C17H35 on the virus yield only when cells were treated before or shortly after infection. In addition to the antiviral activity of the internalized compound, we show that the compound dramatically reduces the infectivity of free virus in the supernatant. Overall, our results demonstrate that activated TMPyP3-C17H35 effectively inhibits HSV-1 replication and that it can be further developed as a potential novel treatment and used as a model to study photodynamic antimicrobial chemotherapy.

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Recent advances in nanoparticle-based targeting tactics for antibacterial photodynamic therapy

Cited by 23 publications

References 109 publications

Perspectives on Usage of Functional Nanomaterials in Antimicrobial Therapy for Antibiotic-Resistant Bacterial Infections

Perspectives on Usage of Functional Nanomaterials in Antimicrobial Therapy for Antibiotic-Resistant Bacterial Infections

TiO2/Karaya Composite for Photoinactivation of Bacteria

Photodynamic Inhibition of Herpes Simplex Virus 1 Infection by Tricationic Amphiphilic Porphyrin with a Long Alkyl Chain

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