Recent advances in nanoplasmonic biosensors: applications and lab-on-a-chip integration

Lopez, Gerardo A.; Estévez, M.‐Carmen; Soler, María; Lechuga, Laura M.

doi:10.1515/nanoph-2016-0101

Cited by 231 publications

(154 citation statements)

References 71 publications

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“…Such optical sensor elements can be sensitive enough to be used in biosensors for monitoring/recognition of molecular scale interactions. [13,14]. The sensitivity of LSPR based devices strongly depends on the used material and also on the size and geometry of the metallic nanoparticles [15].…”

Section: Introductionmentioning

confidence: 99%

Investigation of the performance of thermally generated gold nanoislands for LSPR and SERS applications

Bonyár

Csarnovics

Vereš

et al. 2018

Sensors and Actuators B: Chemical

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In this work, the performance of gold nanoislands was investigated for Localized Surface Plasmon Resonance (LSPR) and Surface Enhanced Raman Spectroscopy (SERS) applications. Nanoislands were generated by thermally annealing thin layers of gold (having thickness in the 6-12 nm range), which was previously deposited by vacuum thermal evaporation onto glass substrates. Gold nanoparticles (AuNP) were evaluated based on their plasmonic and SERS performance and morphological properties. Scanning Electron Microscopy (SEM) was used to measure the average particle size and average interparticle distance in order to correlate them with the obtained plasmonic/Raman capabilities. The technological parameters of nanoisland fabrication for optimal performances were also determined.

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Section: Introductionmentioning

confidence: 99%

Investigation of the performance of thermally generated gold nanoislands for LSPR and SERS applications

Bonyár

Csarnovics

Vereš

et al. 2018

Sensors and Actuators B: Chemical

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“…The isolated CTCs and EVs are subsequently detected by fluorescent visualization or electrochemical and plasmonic sensing, etc., and their molecular biomarkers (e.g., proteins, DNA, and RNA) are analyzed by immunostaining, reverse transcription‐polymerase chain reaction (RT‐PCR), and sequencing, etc. ( Figure ) . Various nanomaterials, nanostructures, and molecular probes have been developed for the enrichment and analysis of CTCs and EVs, and have been successfully applied in the clinic, showing the potential of nanotechnology‐based liquid biopsy in early diagnosis, dynamic monitoring, treatment response evaluation, point‐of‐care testing (POCT), and prognosis prediction ( Figure ) .…”

Section: Advances and Challenges Of Nanotechnology‐based Liquid Biopsymentioning

confidence: 99%

Emerging Nanotechnologies for Liquid Biopsy: The Detection of Circulating Tumor Cells and Extracellular Vesicles

Li¹,

Wang²,

Zhao³

et al. 2018

Advanced Materials

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Liquid biopsy enables noninvasive and dynamic analysis of molecular or cellular biomarkers, and therefore holds great potential for the diagnosis, prognosis, monitoring of disease progress and treatment efficacy, understanding of disease mechanisms, and identification of therapeutic targets for drug development. In this review, the recent progress in nanomaterials, nanostructures, nanodevices, and nanosensors for liquid biopsy is summarized, with a focus on the detection and molecular characterization of circulating tumor cells (CTCs) and extracellular vesicles (EVs). The developments and advances of nanomaterials and nanostructures in enhancing the sensitivity, specificity, and purity for the detection of CTCs and EVs are discussed. Sensing techniques for signal transduction and amplification as well as visualization strategies are also discussed. New technologies for the reversible release of the isolated CTCs and EVs and for single‐CTC/EV analysis are summarized. Emerging microfluidic platforms for the integral on‐chip isolation, detection, and molecular analysis are also included. The opportunities, challenges, and prospects of these innovative materials and technologies, especially with regard to their feasibility in clinical applications, are discussed. The applications of nanotechnology‐based liquid biopsy will bring new insight into the clinical practice in monitoring and treatment of tumor and other significant diseases.

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“…The rapid advances in nanotechnologies have significantly boosted the performance of traditional optical biosensors, offering a new level of sensitivity (see section 13), enhanced specificity (see section 12), as well as improved integration capability [140]. This section will discuss the current challenges and future opportunities of nanobiosensing technologies in drug discovery.…”

Section: Nanobiosensors For Drug Discoverymentioning

confidence: 99%

Roadmap on optical sensors

Ferreira

Castro-Camus

Ottaway

et al. 2017

J. Opt.

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Sensors are devices or systems able to detect, measure and convert magnitudes from any domain to an electrical one. Using light as a probe for optical sensing is one of the most efficient approaches for this purpose. The history of optical sensing using some methods based on absorbance, emissive and florescence properties date back to the 16th century. The field of optical sensors evolved during the following centuries, but it did not achieve maturity until the demonstration of the first laser in 1960. The unique properties of laser light become particularly important in the case of laser-based sensors, whose operation is entirely based upon the direct detection of laser light itself, without relying on any additional mediating device. However, compared with freely propagating light beams, artificially engineered optical fields are in increasing demand for probing samples with very small sizes and/or weak light–matter interaction. Optical fiber sensors constitute a subarea of optical sensors in which fiber technologies are employed. Different types of specialty and photonic crystal fibers provide improved performance and novel sensing concepts. Actually, structurization with wavelength or subwavelength feature size appears as the most efficient way to enhance sensor sensitivity and its detection limit. This leads to the area of micro- and nano-engineered optical sensors. It is expected that the combination of better fabrication techniques and new physical effects may open new and fascinating opportunities in this area. This roadmap on optical sensors addresses different technologies and application areas of the field. Fourteen contributions authored by experts from both industry and academia provide insights into the current state-of-the-art and the challenges faced by researchers currently. Two sections of this paper provide an overview of laser-based and frequency comb-based sensors. Three sections address the area of optical fiber sensors, encompassing both conventional, specialty and photonic crystal fibers. Several other sections are dedicated to micro- and nano-engineered sensors, including whispering-gallery mode and plasmonic sensors. The uses of optical sensors in chemical, biological and biomedical areas are described in other sections. Different approaches required to satisfy applications at visible, infrared and THz spectral regions are also discussed. Advances in science and technology required to meet challenges faced in each of these areas are addressed, together with suggestions on how the field could evolve in the near future.

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Recent advances in nanoplasmonic biosensors: applications and lab-on-a-chip integration

Cited by 231 publications

References 71 publications

Investigation of the performance of thermally generated gold nanoislands for LSPR and SERS applications

Investigation of the performance of thermally generated gold nanoislands for LSPR and SERS applications

Emerging Nanotechnologies for Liquid Biopsy: The Detection of Circulating Tumor Cells and Extracellular Vesicles

Roadmap on optical sensors

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