Recent advances in nanotechnology for combating Alzheimer's disease

Abstract

This review provides an overview of recent advances in nanotechnology that are achieved to improve the therapeutic efficiency for treating Alzheimer's disease.

Precise Modulation of Pericyte Dysfunction by a Multifunctional Nanoprodrug to Ameliorate Alzheimer’s Disease

“…Since pericytes play a key role in regulating immune responses in the NVU, we wondered whether amelioration of pericyte dysfunction also suppressed neuroinflammation. Microglia, the resident immune cells adjacent to pericytes in the NVU, become activated and exhibit macrophage-like functions upon encountering abnormal protein aggregates, dead cells, and secreted factors of pericyte inflammation. , Importantly, chronic activation of microglia in AD leads to the excessive release of proinflammatory factors, resulting in neuronal death and dystrophic changes in pericytes . In both the hippocampal and cortical regions of APP/PS1 mice, numerous activated microglia showed enlarged cell bodies, aberrant proliferation, and clustering around Aβ plaques (Figure A).…”

Lipid nanoparticle mediated small interfering RNA delivery as a potential therapy for Alzheimer's disease

“…Researchers aim to overcome the limitations of traditional siRNA delivery methods by using LNPs, which opens new possibilities for the treatment of AD (Tagalakis et al, 2014;Samaridou, Walgrave, et al, 2020;Wong et al, 2012;Xiao et al, 2017). The incorporation of nanotechnology (Hu et al, 2023) into the field of RNAi is a crucial advancement in unlocking the therapeutic benefits of siRNA in the treatment of neurodegenerative disorders (Baranowska-W ojcik & Szwajgier, 2020; Samaridou, Walgrave, et al, 2020). This review aims to explore the intricate link between LNPs and siRNA in the context of AD therapy.…”