Recent advances in nanotherapeutic strategies for spinal cord injury repair

Song, Young Hye; Agrawal, Nikunj; Griffin, Jonathan M.; Schmidt, Christine E.

doi:10.1016/j.addr.2018.12.011

Cited by 88 publications

(81 citation statements)

References 303 publications

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“…Injured mice treated with TA‐PPy‐2 increased from 0 to 14 over 6 weeks, while untreated mice recovered function only to a score of 7. This exemplary treatment shows the promise of conductive elements to neuronal tissue engineering, competitive and combinable with other avenues …”

Section: Conductive Scaffolds For Neuronal Tissue Engineeringmentioning

confidence: 95%

Conductive Scaffolds for Cardiac and Neuronal Tissue Engineering: Governing Factors and Mechanisms

Burnstine‐Townley

Eshel

Amdursky

2019

Adv Funct Materials

119

102

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Tissue engineering is a promising therapeutic approach in medicine, targeting the replacement of a diseased tissue with a healthy one grown within an artificial scaffold. Due to the high prevalence of cardiac and brain‐related ailments that involve some necrosis of tissue, cardiac and neuronal tissue engineering are intensely studied fields in regenerative medicine. A growing trend in the use of conductive scaffolds for the growth of these tissues has been witnessed recently. While the results are irrefutable, the mechanism of how an electrically conducting scaffold interacts with an electroactive tissue remains has remained elusive. An up‐to‐date summary of all work done in the field is reported, with a special focus on the specific contribution of the conductive scaffold on the performance of the formed tissue. The cell–scaffold electronic interface is then explored from an electrical engineering perspective. The electronic configuration of the system and the mechanisms and governing factors controlling the ability of a conductive scaffold to support cardiac and neuronal tissues are discussed. Using several simulations, the required conductivity of the scaffold in order for it to be suitable for tissue engineering—which also depends on the nature of the charge carriers—is also discussed.

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Section: Conductive Scaffolds For Neuronal Tissue Engineeringmentioning

confidence: 95%

Conductive Scaffolds for Cardiac and Neuronal Tissue Engineering: Governing Factors and Mechanisms

Burnstine‐Townley

Eshel

Amdursky

2019

Adv Funct Materials

119

102

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“…Recently, optoPAIN, an optogenetic platform to noninvasively assess changes in pain sensitivity, has been developed and used to examine pharmacological and chemogenetic inhibition of pain [48]. Such techniques and developments hold the promise to see optogenetics in clinical setting in the near future [51,52].…”

Section: Concluding Remarks and Future Prospectivementioning

confidence: 99%

Optogenetics: Therapeutic spark in neuropathic pain

Liu

Wang

2019

Bosn J of Basic Med Sci

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Optogenetics is an emerging field, which uses light and molecular genetics to manipulate the activity of live cells by expressing light-sensitive proteins. With the discovery of bacteriorhodopsin, a light-sensitive bacterial protein, in 1971 Oesterhelt and Stoeckenius laid the pavement of optogenetics. However, the cross-integration of different disciplines is a little more than a decade old. The toolbox contains fluorescent sensors and optogenetic actuators which enable visualization of signaling events and manipulation of cellular activities, respectively. Neuropathic pain is a pain caused either by damage or disease that affects the somatosensory system. The exact mechanism for the neuropathic pain is not known, however proposed mechanisms include immune reactions, ion channel expressions, and inflammation. Current regimen for the disease provides about 50% relief for only 40-60% of patients. Recent in vivo and in vitro studies demonstrate the potential therapeutic applications of optogenetics by manipulating the activity of neurons. This review summarizes the basic concept, therapeutic applications for neuropathy and potential of optogenetics to reach from bench to bedside in the near future.

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“…1,2 TSCI usually leads to sensory, motor impairments, as well as neurogenic bladder and autonomic dysfunctions, throughout a patient's lifetime. [3][4][5][6] The devastating events ultimately impact a patient's physical, psychological, and social well-being throughout the lifespan. 7,8 The pathophysiological progression of TSCI consists of primary injury and secondary injury cascades.…”

Section: Introductionmentioning

confidence: 99%

“…4,9,10 The primary injury occurs immediately after mechanical disruption and dislocation of the vertebral column, which causes compression or transection of the spinal cord. 4,5,11 Immediately after the primary injury, a sustained secondary injury cascade occurs, which leads to further damage to the spinal cord and neurological dysfunction. 4,5,[10][11][12][13] Thus, it is of great importance to mitigate secondary injury in the clinical treatment of acute TSCI.…”

Section: Introductionmentioning

confidence: 99%

“…4,5,11 Immediately after the primary injury, a sustained secondary injury cascade occurs, which leads to further damage to the spinal cord and neurological dysfunction. 4,5,[10][11][12][13] Thus, it is of great importance to mitigate secondary injury in the clinical treatment of acute TSCI. Currently, high-dose administration of methylprednisolone sodium succinate is the only recommended neuroprotective drug available for ameliorating secondary injury after acute TSCI.…”

Section: Introductionmentioning

confidence: 99%

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<p>Selenium-Doped Carbon Quantum Dots Efficiently Ameliorate Secondary Spinal Cord Injury via Scavenging Reactive Oxygen Species</p>

Luo¹,

Wang²,

Liu³

et al. 2020

IJN

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Background The excess production of reactive oxygen species (ROS) after traumatic spinal cord injury (TSCI) has been identified as a leading cause of secondary injury, which can significantly exacerbate acute damage in the injured spinal cord. Thus, scavenging of ROS has emerged as an effective route to ameliorate secondary spinal cord injury. Purpose Selenium-doped carbon quantum dots (Se-CQDs) with the ability to scavenge reactive oxygen species were prepared and used for efficiently ameliorating secondary injury in TSCI. Methods Water-soluble Se-CQDs were easily synthesized via hydrothermal treatment of l -selenocystine. The chemical structure, size, and morphology of the Se-CQDs were characterized in detail. The biocompatibility and protective effects of the Se-CQDs against H 2 O 2 -induced oxidative damage were investigated in vitro. Moreover, the behavioral test, bladder function, histological observation, Western blot were used to investigate the neuroprotective effect of Se-CQDs in a rat model of contusion TSCI. Results The obtained Se-CQDs exhibited good biocompatibility and remarkable protective effect against H 2 O 2 -induced oxidative damage in astrocytes and PC12 cells. Moreover, Se-CQDs displayed marked anti-inﬂammatory and anti-apoptotic activities, which thereby reduced the formation of glial scars and increased the survival of neurons with unscathed myelin sheaths in vivo. As a result, Se-CQDs were capable of largely improving locomotor function of rats with TSCI. Conclusion This study suggests that Se-CQDs can be used as a promising therapeutic platform for ameliorating secondary injury in TSCI.

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Recent advances in nanotherapeutic strategies for spinal cord injury repair

Cited by 88 publications

References 303 publications

Conductive Scaffolds for Cardiac and Neuronal Tissue Engineering: Governing Factors and Mechanisms

Conductive Scaffolds for Cardiac and Neuronal Tissue Engineering: Governing Factors and Mechanisms

Optogenetics: Therapeutic spark in neuropathic pain

<p>Selenium-Doped Carbon Quantum Dots Efficiently Ameliorate Secondary Spinal Cord Injury via Scavenging Reactive Oxygen Species</p>

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