Recent advances in natural polysaccharides-based controlled release nanosystems for anti-cancer phototherapy

Xu, Haiting; Nie, Wenbiao; Dai, Linxin; Luo, Rui; Lin, Dasheng; Zhang, Minyue; Zhang, Jinming; Gao, Fei

doi:10.1016/j.carbpol.2022.120311

Cited by 22 publications

(13 citation statements)

References 178 publications

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“…Well-designed nanocarriers can target special tissue and/or cells through specific interaction with biomacromolecules and receptors (Liu et al, 2022;Bhaladhare and Bhattacharjee, 2023). Since the approval of adriamycin liposomes in 1995, nearly 250 kinds of nanotherapeutic drugs have been studied in preclinical or clinical research, especially in cancer therapy (Zhang et al, 2015;Xu et al, 2023). It is worth noting that there are increasing nanotherapeutic studies focusing on atherosclerosis therapy (Soumya and Raghu, 2023).…”

Section: Introductionmentioning

confidence: 99%

Targeting macrophages in atherosclerosis using nanocarriers loaded with liver X receptor agonists: A narrow review

Yang

Miao²,

Yu³

et al. 2023

Front. Mol. Biosci.

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Macrophages are involved in the whole process of atherosclerosis, which is characterized by accumulation of lipid and inflammation. Presently, clinically used lipid-lowering drugs cannot completely retard the progress of atherosclerosis. Liver X receptor (LXR) plays a key role in regulation of lipid metabolism and inflammation. Accumulating evidence have demonstrated that synthetic LXR agonists can significantly retard the development of atherosclerosis. However, these agonists induce sever hypertriglyceridemia and liver steatosis. These side effects have greatly limited their potential application for therapy of atherosclerosis. The rapid development of drug delivery system makes it possible to delivery interested drugs to special organs or cells using nanocarriers. Macrophages express various receptors which can recognize and ingest specially modified nanocarriers loaded with LXR agonists. In the past decades, a great progress has been made in this field. These macrophage-targeted nanocarriers loaded with LXR agonists are found to decrease atherosclerosis by reducing cholesterol accumulation and inflammatory reactions. Of important, these nanocarriers can alleviate side effects of LXR agonists. In this article, we briefly review the roles of macrophages in atherosclerosis, mechanisms of action of LXR agonists, and focus on the advances of macrophage-targeted nanocarriers loaded with LXR agonists. This work may promote the potential clinical application of these nanocarriers.

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Section: Introductionmentioning

confidence: 99%

Targeting macrophages in atherosclerosis using nanocarriers loaded with liver X receptor agonists: A narrow review

Yang

Miao²,

Yu³

et al. 2023

Front. Mol. Biosci.

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“…It is worth noting that the ability of nanogels to cross biological barriers and deliver agents intracellularly through endocytosis makes them an attractive candidate for advanced drug delivery systems [ 126 , 127 ]. Nanogels also offer a solution to the problem of fast clearance of phototherapeutic agents in vivo by utilizing enhanced permeability and retention (EPR) effect to enhance their retention in tumors, thereby improving the therapeutic outcome of phototherapy for tumor treatment [ 7 , 21 ]. Specifically, the EPR effect is primarily attributed to the aggressive proliferation of tumor cells, which leads to the consumption of local nutrients and irregular blood vessel formation.…”

Section: Hydrogelsmentioning

confidence: 99%

“…Although phototherapy has achieved significant success, its extended clinical application is limited by the evident phototoxicity of traditional phototherapeutic methods [ 7 , 21 , 22 , 23 , 24 ]. The main cause of phototoxicity is the uncontrolled distribution of phototherapeutic agents, which can cause off-target effects in normal tissues, including the skin, blood vessels, and liver, when exposed to natural light, ultimately resulting in the damage of normal cells.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Hydrogel-Based Phototherapy for Tumor Treatment

Gan

Zhang

et al. 2023

Gels

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Phototherapeutic agent-based phototherapies activated by light have proven to be safe modalities for the treatment of various malignant tumor indications. The two main modalities of phototherapies include photothermal therapy, which causes localized thermal damage to target lesions, and photodynamic therapy, which causes localized chemical damage by generated reactive oxygen species (ROS). Conventional phototherapies suffer a major shortcoming in their clinical application due to their phototoxicity, which primarily arises from the uncontrolled distribution of phototherapeutic agents in vivo. For successful antitumor phototherapy, it is essential to ensure the generation of heat or ROS specifically occurs at the tumor site. To minimize the reverse side effects of phototherapy while improving its therapeutic performance, extensive research has focused on developing hydrogel-based phototherapy for tumor treatment. The utilization of hydrogels as drug carriers allows for the sustained delivery of phototherapeutic agents to tumor sites, thereby limiting their adverse effects. Herein, we summarize the recent advancements in the design of hydrogels for antitumor phototherapy, offer a comprehensive overview of the latest advances in hydrogel-based phototherapy and its combination with other therapeutic modalities for tumor treatment, and discuss the current clinical status of hydrogel-based antitumor phototherapy.

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“…Water solubilization of hydrophobic guest molecules is important to realize their functionalization and application in the fields of material chemistry and medicinal chemistry. [1][2][3][4][5][6][7][8][9][10][11][12] To this aim, the use of solubilizing agents helps reduce time and costs and broadens potential applications. Especially, using natural products as solubilizing agents leads to an excellent biocompatibility and a low environmental burden.…”

Section: Introductionmentioning

confidence: 99%

“…Similarly, polysaccharides and polypeptides can include a large amount and variety of guest molecules (Figure 1). [7][8][9][10][11][12][13] However, the preparation of complexes of CDxs, polysaccharides, and polypeptides with guest molecules via traditional solid-liquid extraction methods using sonication or heating requires long reaction times and affords aqueous solutions with relatively low concentrations of guest molecules. In contrast, these complexes can be rapidly and conveniently prepared using a mechanochemical high-speed vibration milling (HSVM) apparatus (Scheme 1a).…”

Section: Introductionmentioning

confidence: 99%

“On‐Off” Switching of Functional Guest Molecules via Exchange of Natural Product Solubilizing Agents

Kawasaki

Ikeda

2023

ChemBioChem

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For the development of delivery systems, the solubilization of hydrophobic guest molecules in water is an important yet challenging task. This can be achieved by preparing stable aqueous solutions with a high concentration of guest molecules using a natural product as a solubilizing agent and a mechanochemical high‐speed vibration milling apparatus as a solubilizing method. Various solubilizing agent‐guest molecule complexes can be obtained via the exchange between solubilizing agents, which enables the “on‐off” switching of the properties of functional guest molecules, such as fluorescence intensity, and photodynamic activity. In the exchange method, guest molecules can transfer into cell membranes such as lysosomes and exosomes. Therefore, the exchange method of the solubilizing agents not only creates novel solubilizing agent‐guest molecule complexes but also is applied to drug delivery systems.

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Recent advances in natural polysaccharides-based controlled release nanosystems for anti-cancer phototherapy

Cited by 22 publications

References 178 publications

Targeting macrophages in atherosclerosis using nanocarriers loaded with liver X receptor agonists: A narrow review

Targeting macrophages in atherosclerosis using nanocarriers loaded with liver X receptor agonists: A narrow review

Recent Advances in Hydrogel-Based Phototherapy for Tumor Treatment

“On‐Off” Switching of Functional Guest Molecules via Exchange of Natural Product Solubilizing Agents

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